中国科学院水生生物研究所机构知识库
Advanced  
IHB OpenIR  > 水生生物分子与细胞生物学研究中心  > 期刊论文
题名: Association between the APC gene D1822V variant and the genetic susceptibility of colorectal cancer
作者: Feng, Maohui1; Fang, Xiping2; Yang, Qian1; Ouyang, Gang3; Chen, Daping1; Ma, Xiang1; Li, Huachi1; Xie, Wei1
关键词: colorectal cancer ; APC gene ; single nucleotide polymorphism ; genetic susceptibility
刊名: ONCOLOGY LETTERS
发表日期: 2014-07-01
DOI: 10.3892/ol.2014.2102
卷: 8, 期:1, 页:139-144
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Oncology
研究领域[WOS]: Oncology
英文摘要: Adenomatous polyposis coli (APC) gene polymorphisms are believed to contribute to tumor susceptibility. However, the association between genetic variants (A/T) in the APC gene D1822V polymorphism and colorectal cancer (CRC) susceptibility remains unknown. To determine this association, a case-control study was performed.. The genotype of the APC gene D1822V variants was analyzed by DNA sequencing in blood samples collected from 196 patients with CRC and 279 healthy subjects. There were no significant associations between the case and control groups in the distribution of AT [odds ratio (OR), 0.604; 95% confidence interval (CI), 0.355-1.029) and TT genotypes (OR, 0.438; 95% CI, 0.045-4.247) relative to the AA genotype. The ratio of the T allele was significantly lower (P=0.047) in the case group compared with the control group (OR, 0.611; 95% CI, 0.374-0.997), indicating that the T allele conferred a protective effect in CRC. The frequency of the AT genotype among the subjects diagnosed at >45 years of age was lower than those diagnosed at a younger age (P<0.05). The present study demonstrates that the T allele of the D1822V polymorphism may exert a protective effect against CRC, however, these findings require further validation in a larger sample size.
关键词[WOS]: KSP-CADHERIN ; LI-CADHERIN ; RISK ; POLYMORPHISMS ; PREDISPOSITION ; ALLELES ; PROTEIN ; STYLE ; DNA
语种: 英语
WOS记录号: WOS:000338179100025
ISSN号: 1792-1074
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/20387
Appears in Collections:水生生物分子与细胞生物学研究中心_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
Association between the APC gene D1822V variant and the genetic susceptibility of colorectal cancer.pdf(595KB)----开放获取View Download

作者单位: 1.Wuhan Univ, Dept Oncol, Zhongnan Hosp, Wuhan 430071, Hubei, Peoples R China
2.Cent Hosp Enshi Prefecture, Dept Oncol, Enshi 445000, Hubei, Peoples R China
3.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Hubei, Peoples R China

Recommended Citation:
Feng, Maohui; Fang, Xiping; Yang, Qian; Ouyang, Gang; Chen, Daping; Ma, Xiang; Li, Huachi; Xie, Wei.Association between the APC gene D1822V variant and the genetic susceptibility of colorectal cancer,ONCOLOGY LETTERS,2014,():
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Feng, Maohui]'s Articles
[Fang, Xiping]'s Articles
[Yang, Qian]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Feng, Maohui]‘s Articles
[Fang, Xiping]‘s Articles
[Yang, Qian]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Association between the APC gene D1822V variant and the genetic susceptibility of colorectal cancer.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  中国科学院水生生物研究所 - Feedback
Powered by CSpace