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Association between the APC gene D1822V variant and the genetic susceptibility of colorectal cancer
Feng, Maohui1; Fang, Xiping2; Yang, Qian1; Ouyang, Gang3; Chen, Daping1; Ma, Xiang1; Li, Huachi1; Xie, Wei1
2014-07-01
Source PublicationONCOLOGY LETTERS
ISSN1792-1074
Volume8Issue:1Pages:139-144
AbstractAdenomatous polyposis coli (APC) gene polymorphisms are believed to contribute to tumor susceptibility. However, the association between genetic variants (A/T) in the APC gene D1822V polymorphism and colorectal cancer (CRC) susceptibility remains unknown. To determine this association, a case-control study was performed.. The genotype of the APC gene D1822V variants was analyzed by DNA sequencing in blood samples collected from 196 patients with CRC and 279 healthy subjects. There were no significant associations between the case and control groups in the distribution of AT [odds ratio (OR), 0.604; 95% confidence interval (CI), 0.355-1.029) and TT genotypes (OR, 0.438; 95% CI, 0.045-4.247) relative to the AA genotype. The ratio of the T allele was significantly lower (P=0.047) in the case group compared with the control group (OR, 0.611; 95% CI, 0.374-0.997), indicating that the T allele conferred a protective effect in CRC. The frequency of the AT genotype among the subjects diagnosed at >45 years of age was lower than those diagnosed at a younger age (P<0.05). The present study demonstrates that the T allele of the D1822V polymorphism may exert a protective effect against CRC, however, these findings require further validation in a larger sample size.
SubtypeArticle
KeywordColorectal Cancer Apc Gene Single Nucleotide Polymorphism Genetic Susceptibility
DOI10.3892/ol.2014.2102
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Language英语
WOS Research AreaOncology
WOS SubjectOncology
WOS IDWOS:000338179100025
WOS KeywordKSP-CADHERIN ; LI-CADHERIN ; RISK ; POLYMORPHISMS ; PREDISPOSITION ; ALLELES ; PROTEIN ; STYLE ; DNA
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Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/20387
Collection水生生物分子与细胞生物学研究中心_期刊论文
Affiliation1.Wuhan Univ, Dept Oncol, Zhongnan Hosp, Wuhan 430071, Hubei, Peoples R China
2.Cent Hosp Enshi Prefecture, Dept Oncol, Enshi 445000, Hubei, Peoples R China
3.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Hubei, Peoples R China
Recommended Citation
GB/T 7714
Feng, Maohui,Fang, Xiping,Yang, Qian,et al. Association between the APC gene D1822V variant and the genetic susceptibility of colorectal cancer[J]. ONCOLOGY LETTERS,2014,8(1):139-144.
APA Feng, Maohui.,Fang, Xiping.,Yang, Qian.,Ouyang, Gang.,Chen, Daping.,...&Xie, Wei.(2014).Association between the APC gene D1822V variant and the genetic susceptibility of colorectal cancer.ONCOLOGY LETTERS,8(1),139-144.
MLA Feng, Maohui,et al."Association between the APC gene D1822V variant and the genetic susceptibility of colorectal cancer".ONCOLOGY LETTERS 8.1(2014):139-144.
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