| Association between the APC gene D1822V variant and the genetic susceptibility of colorectal cancer | |
| Feng, Maohui1; Fang, Xiping2; Yang, Qian1; Ouyang, Gang3; Chen, Daping1; Ma, Xiang1; Li, Huachi1; Xie, Wei1 | |
| 2014-07-01 | |
| Source Publication | ONCOLOGY LETTERS
 |
| ISSN | 1792-1074 |
| Volume | 8Issue:1Pages:139-144 |
| Abstract | Adenomatous polyposis coli (APC) gene polymorphisms are believed to contribute to tumor susceptibility. However, the association between genetic variants (A/T) in the APC gene D1822V polymorphism and colorectal cancer (CRC) susceptibility remains unknown. To determine this association, a case-control study was performed.. The genotype of the APC gene D1822V variants was analyzed by DNA sequencing in blood samples collected from 196 patients with CRC and 279 healthy subjects. There were no significant associations between the case and control groups in the distribution of AT [odds ratio (OR), 0.604; 95% confidence interval (CI), 0.355-1.029) and TT genotypes (OR, 0.438; 95% CI, 0.045-4.247) relative to the AA genotype. The ratio of the T allele was significantly lower (P=0.047) in the case group compared with the control group (OR, 0.611; 95% CI, 0.374-0.997), indicating that the T allele conferred a protective effect in CRC. The frequency of the AT genotype among the subjects diagnosed at >45 years of age was lower than those diagnosed at a younger age (P<0.05). The present study demonstrates that the T allele of the D1822V polymorphism may exert a protective effect against CRC, however, these findings require further validation in a larger sample size. |
| Subtype | Article |
| Keyword | Colorectal Cancer Apc Gene Single Nucleotide Polymorphism Genetic Susceptibility |
| DOI | 10.3892/ol.2014.2102 |
| WOS Headings | Science & Technology ; Life Sciences & Biomedicine |
| Indexed By | SCI |
| Language | 英语 |
| WOS Research Area | Oncology |
| WOS Subject | Oncology |
| WOS ID | WOS:000338179100025 |
| WOS Keyword | KSP-CADHERIN ; LI-CADHERIN ; RISK ; POLYMORPHISMS ; PREDISPOSITION ; ALLELES ; PROTEIN ; STYLE ; DNA |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ihb.ac.cn/handle/342005/20387 |
| Collection | 水生生物分子与细胞生物学研究中心_期刊论文 |
| Affiliation | 1.Wuhan Univ, Dept Oncol, Zhongnan Hosp, Wuhan 430071, Hubei, Peoples R China 2.Cent Hosp Enshi Prefecture, Dept Oncol, Enshi 445000, Hubei, Peoples R China 3.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Hubei, Peoples R China |
| Recommended Citation GB/T 7714 | Feng, Maohui,Fang, Xiping,Yang, Qian,et al. Association between the APC gene D1822V variant and the genetic susceptibility of colorectal cancer[J]. ONCOLOGY LETTERS,2014,8(1):139-144. |
| APA | Feng, Maohui.,Fang, Xiping.,Yang, Qian.,Ouyang, Gang.,Chen, Daping.,...&Xie, Wei.(2014).Association between the APC gene D1822V variant and the genetic susceptibility of colorectal cancer.ONCOLOGY LETTERS,8(1),139-144. |
| MLA | Feng, Maohui,et al."Association between the APC gene D1822V variant and the genetic susceptibility of colorectal cancer".ONCOLOGY LETTERS 8.1(2014):139-144. |
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