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题名: Missing Genes, Multiple ORFs, and C-to-U Type RNA Editing in Acrasis kona (Heterolobosea, Excavata) Mitochondrial DNA
作者: Fu, Cheng-Jie1; Sheikh, Sanea1; Miao, Wei2; Andersson, Siv G. E.3; Baldauf, Sandra L.1
关键词: Discoba ; endosymbiotic gene transfer ; horizontal gene transfer ; codon usage bias ; plant-type RNA editing ; split ribosomal protein gene
刊名: GENOME BIOLOGY AND EVOLUTION
发表日期: 2014-09-01
DOI: 10.1093/gbe/evu180
卷: 6, 期:9, 页:2240-2257
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Evolutionary Biology ; Genetics & Heredity
研究领域[WOS]: Evolutionary Biology ; Genetics & Heredity
英文摘要: Discoba (Excavata) is an ancient group of eukaryotes with great morphological and ecological diversity. Unlike the other major divisions of Discoba (Jakobida and Euglenozoa), little is known about the mitochondrial DNAs(mtDNAs) of Heterolobosea. We have assembled a complete mtDNA genome from the aggregating heterolobosean amoeba, Acrasis kona, which consists of a single circular highly AT-rich (83.3%) molecule of 51.5 kb. Unexpectedly, A. kona mtDNA is missing roughly 40% of the protein-coding genes and nearly half of the transfer RNAs found in the only other sequenced heterolobosean mtDNAs, those of Naegleria spp. Instead, over a quarter of A. kona mtDNA consists of novel open reading frames. Eleven of the 16 protein-coding genes missing from A. kona mtDNA were identified in its nuclear DNA and polyA RNA, and phylogenetic analyses indicate that at least 10 of these 11 putative nuclear-encoded mitochondrial (NcMt) proteins arose by direct transfer from the mitochondrion. Acrasis kona mtDNA also employs C-to-U type RNA editing, and 12 homologs of DYW-type pentatricopeptide repeat (PPR) proteins implicated in plant organellar RNA editing are found in A. kona nuclear DNA. A mapping of mitochondrial gene content onto a consensus phylogeny reveals a sporadic pattern of relative stasis and rampant gene loss in Discoba. Rampant loss occurred independently in the unique common lineage leading to Heterolobosea + Tsukubamonadida and later in the unique lineage leading to Acrasis. Meanwhile, mtDNA gene content appears to be remarkably stable in the Acrasis sister lineage leading to Naegleria and in their distant relatives Jakobida.
关键词[WOS]: PENTATRICOPEPTIDE REPEAT PROTEINS ; CODON USAGE BIAS ; PHYLOGENETIC RECONSTRUCTION ; ACANTHAMOEBA-CASTELLANII ; REVISED CLASSIFICATION ; TARGETING SEQUENCES ; NAEGLERIA-GRUBERI ; GENOME ; EVOLUTION ; ORIGIN
语种: 英语
WOS记录号: WOS:000343249300007
ISSN号: 1759-6653
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/20382
Appears in Collections:水生生物分子与细胞生物学研究中心_期刊论文

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作者单位: 1.Uppsala Univ, Program Systemat Biol, Dept Organismal Biol, Evolutionary Biol Ctr, Uppsala, Sweden
2.Chinese Acad Sci, Key Lab Aquat Biodivers & Conservat, Inst Hydrobiol, Wuhan, Peoples R China
3.Uppsala Univ, Dept Mol Evolut Cell & Mol Biol, Sci Life Lab, Biomed Ctr, Uppsala, Sweden

Recommended Citation:
Fu, Cheng-Jie; Sheikh, Sanea; Miao, Wei; Andersson, Siv G. E.; Baldauf, Sandra L..Missing Genes, Multiple ORFs, and C-to-U Type RNA Editing in Acrasis kona (Heterolobosea, Excavata) Mitochondrial DNA,GENOME BIOLOGY AND EVOLUTION,2014,():
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文件名: Missing Genes, Multiple ORFs, and C-to-U Type RNA Editing in Acrasis kona (Heterolobosea, Excavata) Mitochondrial DNA.pdf
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