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题名: Water exposure assessment of aryl hydrocarbon receptor agonists in Three Gorges Reservoir, China using SPMD-based virtual organisms
作者: Wang, Jingxian1, 2, 3; Bernhoeft, Silke2; Pfister, Gerd2; Schramm, Karl-Werner1, 2
关键词: Hydrophobic organic contaminants (HOCs) ; EROD activity ; TGR (Three Gorges Reservoir) ; Virtual organisms (VOs) ; Non-additive effect
刊名: SCIENCE OF THE TOTAL ENVIRONMENT
发表日期: 2014-10-15
DOI: 10.1016/j.scitotenv.2014.07.015
卷: 496, 页:26-34
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Environmental Sciences
研究领域[WOS]: Environmental Sciences & Ecology
英文摘要: SPMD-based virtual organisms (VOs) were deployed at five to eight sites in the Three Gorges Reservoir (TGR), China for five periods in 2008, 2009 and 2011. The water exposure of aryl hydrocarbon receptor (AhR) agonists was assessed by the VOs. The chosen bioassay response for the extracts of the VOs, the induction of 7-ethoxyresorufin-O-deethylase (EROD) was assayed using a rat hepatoma cell line (H4IIE). The results show that the extracts from the VOs could induce AhR activity significantly, whereas the chemically derived 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) equivalent (TEQ(cal)) accounted for <11% of the observed AhR responses (TEQ(bio)). Unidentified AhR-active compounds represented a greater proportion of the TCDD equivalent in VOs from TGR. High TEQ(bio), value in diluted extract and low TEQ(bio) in concentrated extract of the same sample was observed suggesting potential non-additive effects in the mixture. The levels of AhR agonists in VOs from upstream TGR were in general higher than those from downstream reservoir, indicating urbanization effect on AhR agonist pollution. The temporal variation showed that levels of AhR agonists in 2009 and 2011 were higher than those in 2008, and the potential non-additive effects in the area close to the dam were also obviously higher in 2009 and 2011 than in 2008, indicating big changes in the composition of pollutants in the area after water level reached a maximum of 175 m. Although the aqueous concentration of AhR agonists of 0.8-4.8 pg TCDD L-1 in TGR was not alarming, the tendency of accumulating high concentration of AhR agonists in VO lipid and existence of possible synergism or antagonism in the water may exhibit a potential hazard to local biota being exposed to AhR agonists. (C) 2014 Elsevier B.V. All rights reserved.
关键词[WOS]: POLYCYCLIC AROMATIC-HYDROCARBONS ; DIOXIN-LIKE COMPOUNDS ; IN-VITRO BIOASSAY ; POLYCHLORINATED-BIPHENYLS ; YANGTZE-RIVER ; AH RECEPTOR ; SURFACE SEDIMENTS ; ACTIVE COMPOUNDS ; GENE-EXPRESSION ; WASTE-WATER
语种: 英语
WOS记录号: WOS:000342245600005
ISSN号: 0048-9697
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/20370
Appears in Collections:水环境工程研究中心_期刊论文

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作者单位: 1.TUM, Wissensch Zentrum Weihenstephan Ernahrung Landnut, Dept Biowissensch, D-85350 Freising Weihenstephan, Germany
2.German Res Ctr Environm Hlth GmbH, Helmholtz Ctr Munich, Mol EXpos MEX, D-85764 Neuherberg, Germany
3.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China

Recommended Citation:
Wang, Jingxian; Bernhoeft, Silke; Pfister, Gerd; Schramm, Karl-Werner.Water exposure assessment of aryl hydrocarbon receptor agonists in Three Gorges Reservoir, China using SPMD-based virtual organisms,SCIENCE OF THE TOTAL ENVIRONMENT,2014,():
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