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Bioconcentration and metabolism of BDE-209 in the presence of titanium dioxide nanoparticles and impact on the thyroid endocrine system and neuronal development in zebrafish larvae
Wang, Qiangwei1,2; Chen, Qi1,2; Zhou, Peng3; Li, Wenwen4; Wang, Junxia3; Huang, Changjiang4; Wang, Xianfeng1; Lin, Kuangfei3; Zhou, Bingsheng1
2014-08-01
Source PublicationNANOTOXICOLOGY
ISSN1743-5390
Volume8Issue:-Pages:196-207
AbstractInteractions between organic toxicants and nanoparticles (NPs) in the aquatic environment may modify toxicant bioavailability and consequently the toxicant's environmental fate and toxicity. Therefore, we investigated the influence of titanium dioxide NPs (nano-TiO2) on deca-BDE (BDE-209; a polybrominated diphenyl ether congener) bioconcentration, metabolism and its effects on the thyroid endocrine system in zebrafish (Danio rerio) larvae. Zebrafish embryos were exposed to various concentrations of BDE-209 alone or in combination with nano-TiO2 (0.1 mg/L) until 7-day post-fertilization. Nano-TiO2 can adsorb BDE-209 and nano-TiO2 is taken up into developing zebrafish larvae. Chemical measurements showed that BDE-209 was bioconcentrated and metabolized in zebrafish larvae, and BDE-209 uptake was enhanced by nano-TiO2. Furthermore, increased BDE-209 metabolites were detected in larvae co-exposed with nano-TiO2. BDE-209 exposure significantly increased whole-body thyroid hormone contents (T-3 and T-4); T-4 content significantly increased in the larvae co-exposed with nano-TiO2. Nano-TiO2 exposure alone did not induce generation of reactive oxygen species, lipid peroxidative oxidation, gene transcription or thyroid hormone levels. Upregulation of several gene transcriptions (tsh beta, tg, diO(2)) in the hypothalamic-pituitary-thyroid axis was also observed. Furthermore, co-exposure of nano-TiO2 and BDE-209 caused a decrease in locomotion activity and downregulation of specific genes and proteins involved in the central nervous system of developing zebrafish larvae (e.g. myelin basic protein and alpha 1-tubulin). These results indicate nano-TiO2 enhances BDE-209 bioavailability and metabolism, leading to thyroid endocrine disruption and developmental neurotoxicity in zebrafish.
SubtypeArticle
KeywordBde-209 Bioconcentration And Metabolism Co-exposure Developmental Neurotoxicity Titanium Dioxide Nanoparticles Thyroid Endocrine Disruption Zebrafish Larvae
DOI10.3109/17435390.2013.875232
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics ; Toxicology
WOS SubjectNanoscience & Nanotechnology ; Toxicology
WOS IDWOS:000340524300020
WOS KeywordPOLYBROMINATED DIPHENYL ETHERS ; BROMINATED FLAME-RETARDANT ; TROUT ONCORHYNCHUS-MYKISS ; DECABROMODIPHENYL ETHER ; GENE-EXPRESSION ; RAINBOW-TROUT ; E-WASTE ; 2,2',4,4',5-PENTABROMODIPHENYL ETHER ; AQUEOUS SUSPENSIONS ; SOUTH CHINA
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Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/20365
Collection水环境工程研究中心_期刊论文
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China
3.E China Univ Sci & Technol, State Environm Protect Key Lab Environm Risk Asse, Shanghai 200237, Peoples R China
4.Wenzhou Med Univ, Inst Watershed Sci & Environm Ecol, Wenzhou, Peoples R China
Recommended Citation
GB/T 7714
Wang, Qiangwei,Chen, Qi,Zhou, Peng,et al. Bioconcentration and metabolism of BDE-209 in the presence of titanium dioxide nanoparticles and impact on the thyroid endocrine system and neuronal development in zebrafish larvae[J]. NANOTOXICOLOGY,2014,8(-):196-207.
APA Wang, Qiangwei.,Chen, Qi.,Zhou, Peng.,Li, Wenwen.,Wang, Junxia.,...&Zhou, Bingsheng.(2014).Bioconcentration and metabolism of BDE-209 in the presence of titanium dioxide nanoparticles and impact on the thyroid endocrine system and neuronal development in zebrafish larvae.NANOTOXICOLOGY,8(-),196-207.
MLA Wang, Qiangwei,et al."Bioconcentration and metabolism of BDE-209 in the presence of titanium dioxide nanoparticles and impact on the thyroid endocrine system and neuronal development in zebrafish larvae".NANOTOXICOLOGY 8.-(2014):196-207.
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