中国科学院水生生物研究所机构知识库
Advanced  
IHB OpenIR  > 水环境工程研究中心  > 期刊论文
题名: Bioconcentration and metabolism of BDE-209 in the presence of titanium dioxide nanoparticles and impact on the thyroid endocrine system and neuronal development in zebrafish larvae
作者: Wang, Qiangwei1, 2; Chen, Qi1, 2; Zhou, Peng3; Li, Wenwen4; Wang, Junxia3; Huang, Changjiang4; Wang, Xianfeng1; Lin, Kuangfei3; Zhou, Bingsheng1
关键词: BDE-209 ; bioconcentration and metabolism ; co-exposure ; developmental neurotoxicity ; titanium dioxide nanoparticles ; thyroid endocrine disruption ; zebrafish larvae
刊名: NANOTOXICOLOGY
发表日期: 2014-08-01
DOI: 10.3109/17435390.2013.875232
卷: 8, 期:-, 页:196-207
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Nanoscience & Nanotechnology ; Toxicology
研究领域[WOS]: Science & Technology - Other Topics ; Toxicology
英文摘要: Interactions between organic toxicants and nanoparticles (NPs) in the aquatic environment may modify toxicant bioavailability and consequently the toxicant's environmental fate and toxicity. Therefore, we investigated the influence of titanium dioxide NPs (nano-TiO2) on deca-BDE (BDE-209; a polybrominated diphenyl ether congener) bioconcentration, metabolism and its effects on the thyroid endocrine system in zebrafish (Danio rerio) larvae. Zebrafish embryos were exposed to various concentrations of BDE-209 alone or in combination with nano-TiO2 (0.1 mg/L) until 7-day post-fertilization. Nano-TiO2 can adsorb BDE-209 and nano-TiO2 is taken up into developing zebrafish larvae. Chemical measurements showed that BDE-209 was bioconcentrated and metabolized in zebrafish larvae, and BDE-209 uptake was enhanced by nano-TiO2. Furthermore, increased BDE-209 metabolites were detected in larvae co-exposed with nano-TiO2. BDE-209 exposure significantly increased whole-body thyroid hormone contents (T-3 and T-4); T-4 content significantly increased in the larvae co-exposed with nano-TiO2. Nano-TiO2 exposure alone did not induce generation of reactive oxygen species, lipid peroxidative oxidation, gene transcription or thyroid hormone levels. Upregulation of several gene transcriptions (tsh beta, tg, diO(2)) in the hypothalamic-pituitary-thyroid axis was also observed. Furthermore, co-exposure of nano-TiO2 and BDE-209 caused a decrease in locomotion activity and downregulation of specific genes and proteins involved in the central nervous system of developing zebrafish larvae (e.g. myelin basic protein and alpha 1-tubulin). These results indicate nano-TiO2 enhances BDE-209 bioavailability and metabolism, leading to thyroid endocrine disruption and developmental neurotoxicity in zebrafish.
关键词[WOS]: POLYBROMINATED DIPHENYL ETHERS ; BROMINATED FLAME-RETARDANT ; TROUT ONCORHYNCHUS-MYKISS ; DECABROMODIPHENYL ETHER ; GENE-EXPRESSION ; RAINBOW-TROUT ; E-WASTE ; 2,2',4,4',5-PENTABROMODIPHENYL ETHER ; AQUEOUS SUSPENSIONS ; SOUTH CHINA
语种: 英语
WOS记录号: WOS:000340524300020
ISSN号: 1743-5390
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/20365
Appears in Collections:水环境工程研究中心_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
Bioconcentration and metabolism of BDE-209 in the presence of titanium dioxide nanoparticles and impact on the thyroid endocrine system and neuronal development in zebrafish larvae.pdf(850KB)----开放获取View 联系获取全文

作者单位: 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China
3.E China Univ Sci & Technol, State Environm Protect Key Lab Environm Risk Asse, Shanghai 200237, Peoples R China
4.Wenzhou Med Univ, Inst Watershed Sci & Environm Ecol, Wenzhou, Peoples R China
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wang, Qiangwei]'s Articles
[Chen, Qi]'s Articles
[Zhou, Peng]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wang, Qiangwei]‘s Articles
[Chen, Qi]‘s Articles
[Zhou, Peng]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Bioconcentration and metabolism of BDE-209 in the presence of titanium dioxide nanoparticles and impact on the thyroid endocrine system and neuronal development in zebrafish larvae.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2016  中国科学院水生生物研究所 - Feedback
Powered by CSpace