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Mitochondrial electron transport chain is involved in microcystin-RR induced tobacco BY-2 cells apoptosis
Huang, Wenmin1,2; Li, Dunhai1; Liu, Yongding1
2014-09-01
Source PublicationJOURNAL OF ENVIRONMENTAL SCIENCES-CHINA
ISSN1001-0742
Volume26Issue:9Pages:1930-1935
AbstractMicrocystin-RR (MC-RR) has been suggested to induce apoptosis in tobacco BY-2 cells through mitochondrial dysfunction including the loss of mitochondrial membrane potential (Delta Psi(m)). To further elucidate the mechanisms involved in MC-RR induced apoptosis in tobacco BY-2 cells, we have investigated the role of mitochondrial electron transport chain (ETC) as a potential source for reactive oxygen species (ROS). Tobacco BY-2 cells after exposure to MC-RR (60 mg/L) displayed apoptotic changes in association with an increased production of ROS and loss of Delta Psi(m). All of these adverse effects were significantly attenuated by ETC inhibitors including Rotenone (2 mu mol/L, complex I inhibitor) and antimycin A (0.01 mu mol/L, complex III inhibitor), but not by thenoyltrifluoroacetone (5 mu mol/L, complex II inhibitor). These results suggest that mitochondrial ETC plays a key role in mediating MC-RR induced apoptosis in tobacco BY-2 cells through an increased mitochondrial production of ROS. (C) 2014 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V.
SubtypeArticle
KeywordMicrocystin-rr Tobacco By-2 Cells Apoptosis Reactive Oxygen Species Mitochondrial Electron Transport Chain
DOI10.1016/j.jes.2014.06.032
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Language英语
WOS Research AreaEnvironmental Sciences & Ecology
WOS SubjectEnvironmental Sciences
WOS IDWOS:000341739600022
WOS KeywordSUSPENSION CELLS ; LR ; HEPATOCYTES ; GENERATION ; PATHWAY ; TOXIN ; ACID
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Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/20362
Collection水环境工程研究中心_期刊论文
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, Key Lab Algal Biol, Wuhan 430072, Peoples R China
2.Chinese Acad Sci, Wuhan Bot Garden, Key Lab Aquat Bot & Watershed Ecol, Wuhan 430074, Peoples R China
Recommended Citation
GB/T 7714
Huang, Wenmin,Li, Dunhai,Liu, Yongding. Mitochondrial electron transport chain is involved in microcystin-RR induced tobacco BY-2 cells apoptosis[J]. JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA,2014,26(9):1930-1935.
APA Huang, Wenmin,Li, Dunhai,&Liu, Yongding.(2014).Mitochondrial electron transport chain is involved in microcystin-RR induced tobacco BY-2 cells apoptosis.JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA,26(9),1930-1935.
MLA Huang, Wenmin,et al."Mitochondrial electron transport chain is involved in microcystin-RR induced tobacco BY-2 cells apoptosis".JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA 26.9(2014):1930-1935.
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