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题名: Mitochondrial electron transport chain is involved in microcystin-RR induced tobacco BY-2 cells apoptosis
作者: Huang, Wenmin1, 2; Li, Dunhai1; Liu, Yongding1
关键词: Microcystin-RR ; Tobacco BY-2 cells ; Apoptosis ; Reactive oxygen species ; Mitochondrial electron transport chain
刊名: JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA
发表日期: 2014-09-01
DOI: 10.1016/j.jes.2014.06.032
卷: 26, 期:9, 页:1930-1935
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Environmental Sciences
研究领域[WOS]: Environmental Sciences & Ecology
英文摘要: Microcystin-RR (MC-RR) has been suggested to induce apoptosis in tobacco BY-2 cells through mitochondrial dysfunction including the loss of mitochondrial membrane potential (Delta Psi(m)). To further elucidate the mechanisms involved in MC-RR induced apoptosis in tobacco BY-2 cells, we have investigated the role of mitochondrial electron transport chain (ETC) as a potential source for reactive oxygen species (ROS). Tobacco BY-2 cells after exposure to MC-RR (60 mg/L) displayed apoptotic changes in association with an increased production of ROS and loss of Delta Psi(m). All of these adverse effects were significantly attenuated by ETC inhibitors including Rotenone (2 mu mol/L, complex I inhibitor) and antimycin A (0.01 mu mol/L, complex III inhibitor), but not by thenoyltrifluoroacetone (5 mu mol/L, complex II inhibitor). These results suggest that mitochondrial ETC plays a key role in mediating MC-RR induced apoptosis in tobacco BY-2 cells through an increased mitochondrial production of ROS. (C) 2014 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V.
关键词[WOS]: SUSPENSION CELLS ; LR ; HEPATOCYTES ; GENERATION ; PATHWAY ; TOXIN ; ACID
语种: 英语
WOS记录号: WOS:000341739600022
ISSN号: 1001-0742
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/20362
Appears in Collections:水环境工程研究中心_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Hydrobiol, Key Lab Algal Biol, Wuhan 430072, Peoples R China
2.Chinese Acad Sci, Wuhan Bot Garden, Key Lab Aquat Bot & Watershed Ecol, Wuhan 430074, Peoples R China

Recommended Citation:
Huang, Wenmin; Li, Dunhai; Liu, Yongding.Mitochondrial electron transport chain is involved in microcystin-RR induced tobacco BY-2 cells apoptosis,JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA,2014,():
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