| Mitochondrial electron transport chain is involved in microcystin-RR induced tobacco BY-2 cells apoptosis | |
| Huang, Wenmin1,2; Li, Dunhai1; Liu, Yongding1 | |
| 2014-09-01 | |
| Source Publication | JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA
 |
| ISSN | 1001-0742 |
| Volume | 26Issue:9Pages:1930-1935 |
| Abstract | Microcystin-RR (MC-RR) has been suggested to induce apoptosis in tobacco BY-2 cells through mitochondrial dysfunction including the loss of mitochondrial membrane potential (Delta Psi(m)). To further elucidate the mechanisms involved in MC-RR induced apoptosis in tobacco BY-2 cells, we have investigated the role of mitochondrial electron transport chain (ETC) as a potential source for reactive oxygen species (ROS). Tobacco BY-2 cells after exposure to MC-RR (60 mg/L) displayed apoptotic changes in association with an increased production of ROS and loss of Delta Psi(m). All of these adverse effects were significantly attenuated by ETC inhibitors including Rotenone (2 mu mol/L, complex I inhibitor) and antimycin A (0.01 mu mol/L, complex III inhibitor), but not by thenoyltrifluoroacetone (5 mu mol/L, complex II inhibitor). These results suggest that mitochondrial ETC plays a key role in mediating MC-RR induced apoptosis in tobacco BY-2 cells through an increased mitochondrial production of ROS. (C) 2014 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V. |
| Subtype | Article |
| Keyword | Microcystin-rr Tobacco By-2 Cells Apoptosis Reactive Oxygen Species Mitochondrial Electron Transport Chain |
| DOI | 10.1016/j.jes.2014.06.032 |
| WOS Headings | Science & Technology ; Life Sciences & Biomedicine |
| Indexed By | SCI |
| Language | 英语 |
| WOS Research Area | Environmental Sciences & Ecology |
| WOS Subject | Environmental Sciences |
| WOS ID | WOS:000341739600022 |
| WOS Keyword | SUSPENSION CELLS ; LR ; HEPATOCYTES ; GENERATION ; PATHWAY ; TOXIN ; ACID |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ihb.ac.cn/handle/342005/20362 |
| Collection | 水环境工程研究中心_期刊论文 |
| Affiliation | 1.Chinese Acad Sci, Inst Hydrobiol, Key Lab Algal Biol, Wuhan 430072, Peoples R China 2.Chinese Acad Sci, Wuhan Bot Garden, Key Lab Aquat Bot & Watershed Ecol, Wuhan 430074, Peoples R China |
| Recommended Citation GB/T 7714 | Huang, Wenmin,Li, Dunhai,Liu, Yongding. Mitochondrial electron transport chain is involved in microcystin-RR induced tobacco BY-2 cells apoptosis[J]. JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA,2014,26(9):1930-1935. |
| APA | Huang, Wenmin,Li, Dunhai,&Liu, Yongding.(2014).Mitochondrial electron transport chain is involved in microcystin-RR induced tobacco BY-2 cells apoptosis.JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA,26(9),1930-1935. |
| MLA | Huang, Wenmin,et al."Mitochondrial electron transport chain is involved in microcystin-RR induced tobacco BY-2 cells apoptosis".JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA 26.9(2014):1930-1935. |
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