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题名: Sequence and expression analysis of rainbow trout CXCR2, CXCR3a and CXCR3b aids interpretation of lineage-specific conversion, loss and expansion of these receptors during vertebrate evolution
作者: Xu, Qiaoqing1, 2; Li, Ronggai1; Monte, Milena M.1; Jiang, Yousheng1, 3; Nie, Pin4; Holland, Jason W.1; Secornbes, Chris J.1; Wang, Tiehui1
关键词: Rainbow trout ; OCCR2 ; OCCR3a ; CXCR3b ; Evolution ; Expression
刊名: DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
发表日期: 2014-08-01
DOI: 10.1016/j.dci.2014.03.002
卷: 45, 期:2, 页:201-213
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Immunology ; Zoology
研究领域[WOS]: Immunology ; Zoology
英文摘要: The chemokine receptors CXCR1-3 bind to 11 chemokines (CXCL1-11) that are clustered on the same chromosome in mammals but are largely missing in ray-finned fish. A second CXCR1/2, and a CXCR3a and CXCR3b gene have been cloned in rainbow trout. Analysis of CXCR1-R3 genes in lobe-finned fish, ray-finned fish and tetrapod genomes revealed that the teleostomian ancestor likely possessed loci containing both OCCR1 and CXCR2, and CXCR3a and CXCR3b. Based on this synteny analysis the first trout CXCR1/2 gene was renamed CXCR1, and the new gene CXCR2. The CXCR1/R2 locus was shown to have further expanded in ray-finned fish. In relation to CXCR3, mammals appear to have lost CXCR3b and birds both CXCR3a and CXCR3b during evolution. Trout CXCR1-R3 have distinct tissue expression patterns and are differentially modulated by PAMPs, proinflammatory cytokines and infections. They are highly expressed in macrophages and neutrophils, with CXCR1 and CXCR2 also expressed in B-cells. (C) 2014 The Authors. Published by Elsevier Ltd.
关键词[WOS]: CYPRINUS-CARPIO L. ; PROLIFERATIVE KIDNEY-DISEASE ; ONCORHYNCHUS-MYKISS ; TELEOST FISH ; CHEMOKINE RECEPTORS ; GENE-EXPRESSION ; MOLECULAR-CLONING ; SALMO-GAIRDNERI ; INTERLEUKIN-8 ; NEUTROPHILS
语种: 英语
WOS记录号: WOS:000337856600003
ISSN号: 0145-305X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/20349
Appears in Collections:鱼类生物学及渔业生物技术研究中心_期刊论文

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作者单位: 1.Univ Aberdeen, Scottish Fish Immunol Res Ctr, Sch Biol Sci, Aberdeen AB24 2TZ, Scotland
2.Yangtze Univ, Sch Anim Sci, Jinzhou 434020, Hubei Province, Peoples R China
3.Shanghai Ocean Univ, Coll Fishery & Life Sci, Shanghai 201306, Peoples R China
4.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei Province, Peoples R China

Recommended Citation:
Xu, Qiaoqing; Li, Ronggai; Monte, Milena M.; Jiang, Yousheng; Nie, Pin; Holland, Jason W.; Secornbes, Chris J.; Wang, Tiehui.Sequence and expression analysis of rainbow trout CXCR2, CXCR3a and CXCR3b aids interpretation of lineage-specific conversion, loss and expansion of these receptors during vertebrate evolution,DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2014,():
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文件名: Sequence and expression analysis of rainbow trout CXCR2, CXCR3a and CXCR3b aids interpretation of lineage-specific conversion, loss and expansion of these receptors during vertebrate evolution.pdf
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