IHB OpenIR  > 鱼类生物学及渔业生物技术研究中心  > 期刊论文
Sequence and expression analysis of rainbow trout CXCR2, CXCR3a and CXCR3b aids interpretation of lineage-specific conversion, loss and expansion of these receptors during vertebrate evolution
Xu, Qiaoqing1,2; Li, Ronggai1; Monte, Milena M.1; Jiang, Yousheng1,3; Nie, Pin4; Holland, Jason W.1; Secornbes, Chris J.1; Wang, Tiehui1
2014-08-01
Source PublicationDEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
ISSN0145-305X
Volume45Issue:2Pages:201-213
AbstractThe chemokine receptors CXCR1-3 bind to 11 chemokines (CXCL1-11) that are clustered on the same chromosome in mammals but are largely missing in ray-finned fish. A second CXCR1/2, and a CXCR3a and CXCR3b gene have been cloned in rainbow trout. Analysis of CXCR1-R3 genes in lobe-finned fish, ray-finned fish and tetrapod genomes revealed that the teleostomian ancestor likely possessed loci containing both OCCR1 and CXCR2, and CXCR3a and CXCR3b. Based on this synteny analysis the first trout CXCR1/2 gene was renamed CXCR1, and the new gene CXCR2. The CXCR1/R2 locus was shown to have further expanded in ray-finned fish. In relation to CXCR3, mammals appear to have lost CXCR3b and birds both CXCR3a and CXCR3b during evolution. Trout CXCR1-R3 have distinct tissue expression patterns and are differentially modulated by PAMPs, proinflammatory cytokines and infections. They are highly expressed in macrophages and neutrophils, with CXCR1 and CXCR2 also expressed in B-cells. (C) 2014 The Authors. Published by Elsevier Ltd.
SubtypeArticle
KeywordRainbow Trout Occr2 Occr3a Cxcr3b Evolution Expression
DOI10.1016/j.dci.2014.03.002
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Language英语
WOS Research AreaImmunology ; Zoology
WOS SubjectImmunology ; Zoology
WOS IDWOS:000337856600003
WOS KeywordCYPRINUS-CARPIO L. ; PROLIFERATIVE KIDNEY-DISEASE ; ONCORHYNCHUS-MYKISS ; TELEOST FISH ; CHEMOKINE RECEPTORS ; GENE-EXPRESSION ; MOLECULAR-CLONING ; SALMO-GAIRDNERI ; INTERLEUKIN-8 ; NEUTROPHILS
Citation statistics
Cited Times:34[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/20349
Collection鱼类生物学及渔业生物技术研究中心_期刊论文
Affiliation1.Univ Aberdeen, Scottish Fish Immunol Res Ctr, Sch Biol Sci, Aberdeen AB24 2TZ, Scotland
2.Yangtze Univ, Sch Anim Sci, Jinzhou 434020, Hubei Province, Peoples R China
3.Shanghai Ocean Univ, Coll Fishery & Life Sci, Shanghai 201306, Peoples R China
4.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei Province, Peoples R China
Recommended Citation
GB/T 7714
Xu, Qiaoqing,Li, Ronggai,Monte, Milena M.,et al. Sequence and expression analysis of rainbow trout CXCR2, CXCR3a and CXCR3b aids interpretation of lineage-specific conversion, loss and expansion of these receptors during vertebrate evolution[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2014,45(2):201-213.
APA Xu, Qiaoqing.,Li, Ronggai.,Monte, Milena M..,Jiang, Yousheng.,Nie, Pin.,...&Wang, Tiehui.(2014).Sequence and expression analysis of rainbow trout CXCR2, CXCR3a and CXCR3b aids interpretation of lineage-specific conversion, loss and expansion of these receptors during vertebrate evolution.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,45(2),201-213.
MLA Xu, Qiaoqing,et al."Sequence and expression analysis of rainbow trout CXCR2, CXCR3a and CXCR3b aids interpretation of lineage-specific conversion, loss and expansion of these receptors during vertebrate evolution".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 45.2(2014):201-213.
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