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题名: Edwardsiella tarda-Induced Cytotoxicity Depends on Its Type III Secretion System and Flagellin
作者: Xie, Hai-Xia1, 2; Lu, Jin-Fang1; Rolhion, Nathalie2; Holden, David W.2; Nie, Pin1; Zhou, Ying1; Yu, Xiu-Jun2
关键词: ENTERICA SEROVAR TYPHIMURIUM ; CELL-DEATH ; SALMONELLA-ENTERICA ; GENE-EXPRESSION ; IN-VIVO ; 2-COMPONENT SYSTEM ; NLRC4 INFLAMMASOME ; ESCHERICHIA-COLI ; PHOP-PHOQ ; HOST
刊名: INFECTION AND IMMUNITY
发表日期: 2014-08-01
DOI: 10.1128/IAI.01065-13
卷: 82, 期:8, 页:3436-3445
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Immunology ; Infectious Diseases
研究领域[WOS]: Immunology ; Infectious Diseases
英文摘要: Many Gram-negative bacteria utilize a type III secretion system (T3SS) to translocate virulence proteins into host cells to cause diseases. In responding to infection, macrophages detect some of the translocated proteins to activate caspase-1-mediated cell death, called pyroptosis, and secretion of proinflammatory cytokines to control the infection. Edwardsiella tarda is a Gram-negative enteric pathogen that causes hemorrhagic septicemia in fish and both gastrointestinal and extraintestinal infections in humans. In this study, we report that the T3SS of E. tarda facilitates its survival and replication in murine bone marrow-derived macrophages, and E. tarda infection triggers pyroptosis of infected macrophages from mice and fish and increased secretion of the cytokine interleukin 1 beta in a T3SS-dependent manner. Deletion of the flagellin gene fliC of E. tarda results in decreased cytotoxicity for infected macrophages and does not attenuate its virulence in a fish model of infection, whereas upregulated expression of FliC in the fliC mutant strain reduces its virulence. We propose that the host controls E. tarda infection partially by detecting FliC translocated by the T3SS, whereas the bacteria downregulate the expression of FliC to evade innate immunity.
关键词[WOS]: ENTERICA SEROVAR TYPHIMURIUM ; CELL-DEATH ; SALMONELLA-ENTERICA ; GENE-EXPRESSION ; IN-VIVO ; 2-COMPONENT SYSTEM ; NLRC4 INFLAMMASOME ; ESCHERICHIA-COLI ; PHOP-PHOQ ; HOST
语种: 英语
WOS记录号: WOS:000339161400032
ISSN号: 0019-9567
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/20348
Appears in Collections:鱼类生物学及渔业生物技术研究中心_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Peoples R China
2.Univ London Imperial Coll Sci Technol & Med, Ctr Mol Bacteriol & Infect, MRC, Microbiol Sect, London, England

Recommended Citation:
Xie, Hai-Xia; Lu, Jin-Fang; Rolhion, Nathalie; Holden, David W.; Nie, Pin; Zhou, Ying; Yu, Xiu-Jun.Edwardsiella tarda-Induced Cytotoxicity Depends on Its Type III Secretion System and Flagellin,INFECTION AND IMMUNITY,2014,():
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