| Thymus cDNA library survey uncovers novel features of immune molecules in Chinese giant salamander Andrias davidianus | |
| Zhu, Rong; Chen, Zhong-Yuan; Wang, Jun; Yuan, Jiang-Di; Liao, Xiang-Yong; Gui, Jian-Fang; Zhang, Qi-Ya | |
| 2014-10-01 | |
| Source Publication | DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
 |
| ISSN | 0145-305X |
| Volume | 46Issue:2Pages:413-422 |
| Abstract | A ranavirus-induced thymus cDNA library was constructed from Chinese giant salamander, the largest extant amphibian species. Among the 137 putative immune-related genes derived from this library, these molecules received particular focus: immunoglobulin heavy chains (IgM, IgD, and IgY), IFN-inducible protein 6 (IFI6), and T cell receptor beta chain (TCR beta). Several unusual features were uncovered: IgD displays a structure pattern distinct from those described for other amphibians by having only four constant domains plus a hinge region. A unique IgY form (IgY(Delta Fc)), previously undescribed in amphibians, is present in serum. Alternative splicing is observed to generate IgH diversification. IFI6 is newly-identified in amphibians, which occurs in two forms divergent in subcelluar distribution and antiviral activity. TCR beta immunoscope profile follows the typical vertebrate pattern, implying a polyclonal T cell repertoire. Collectively, the pioneering survey of ranavirus-induced thymus cDNA library from Chinese giant salamander reveals immune components and characteristics in this primitive amphibian. (C) 2014 Elsevier Ltd. All rights reserved. |
| Subtype | Article |
| Keyword | Immune Gene Immunoglobulin Chinese Giant Salamander Andrias Davidianus Thymus Cdna Library Ranavirus-induced |
| DOI | 10.1016/j.dci.2014.05.019 |
| WOS Headings | Science & Technology ; Life Sciences & Biomedicine |
| Indexed By | SCI |
| Language | 英语 |
| WOS Research Area | Immunology ; Zoology |
| WOS Subject | Immunology ; Zoology |
| WOS ID | WOS:000340216600032 |
| WOS Keyword | IMMUNOGLOBULIN HEAVY-CHAIN ; EXTENSIVE DIVERSIFICATION ; XENOPUS-TROPICALIS ; AMPHIBIAN XENOPUS ; IGD ; IDENTIFICATION ; GENES ; EXPRESSION ; DISCOVERY ; LAEVIS |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ihb.ac.cn/handle/342005/20336 |
| Collection | 鱼类生物学及渔业生物技术研究中心_期刊论文 |
| Affiliation | Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China |
| Recommended Citation GB/T 7714 | Zhu, Rong,Chen, Zhong-Yuan,Wang, Jun,et al. Thymus cDNA library survey uncovers novel features of immune molecules in Chinese giant salamander Andrias davidianus[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2014,46(2):413-422. |
| APA | Zhu, Rong.,Chen, Zhong-Yuan.,Wang, Jun.,Yuan, Jiang-Di.,Liao, Xiang-Yong.,...&Zhang, Qi-Ya.(2014).Thymus cDNA library survey uncovers novel features of immune molecules in Chinese giant salamander Andrias davidianus.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,46(2),413-422. |
| MLA | Zhu, Rong,et al."Thymus cDNA library survey uncovers novel features of immune molecules in Chinese giant salamander Andrias davidianus".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 46.2(2014):413-422. |
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| Thymus cDNA library （2715KB） | 开放获取 | CC BY-NC-SA | View Application Full Text | |||
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