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Thymus cDNA library survey uncovers novel features of immune molecules in Chinese giant salamander Andrias davidianus
Zhu, Rong; Chen, Zhong-Yuan; Wang, Jun; Yuan, Jiang-Di; Liao, Xiang-Yong; Gui, Jian-Fang; Zhang, Qi-Ya
2014-10-01
Source PublicationDEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
ISSN0145-305X
Volume46Issue:2Pages:413-422
AbstractA ranavirus-induced thymus cDNA library was constructed from Chinese giant salamander, the largest extant amphibian species. Among the 137 putative immune-related genes derived from this library, these molecules received particular focus: immunoglobulin heavy chains (IgM, IgD, and IgY), IFN-inducible protein 6 (IFI6), and T cell receptor beta chain (TCR beta). Several unusual features were uncovered: IgD displays a structure pattern distinct from those described for other amphibians by having only four constant domains plus a hinge region. A unique IgY form (IgY(Delta Fc)), previously undescribed in amphibians, is present in serum. Alternative splicing is observed to generate IgH diversification. IFI6 is newly-identified in amphibians, which occurs in two forms divergent in subcelluar distribution and antiviral activity. TCR beta immunoscope profile follows the typical vertebrate pattern, implying a polyclonal T cell repertoire. Collectively, the pioneering survey of ranavirus-induced thymus cDNA library from Chinese giant salamander reveals immune components and characteristics in this primitive amphibian. (C) 2014 Elsevier Ltd. All rights reserved.
SubtypeArticle
KeywordImmune Gene Immunoglobulin Chinese Giant Salamander Andrias Davidianus Thymus Cdna Library Ranavirus-induced
DOI10.1016/j.dci.2014.05.019
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Language英语
WOS Research AreaImmunology ; Zoology
WOS SubjectImmunology ; Zoology
WOS IDWOS:000340216600032
WOS KeywordIMMUNOGLOBULIN HEAVY-CHAIN ; EXTENSIVE DIVERSIFICATION ; XENOPUS-TROPICALIS ; AMPHIBIAN XENOPUS ; IGD ; IDENTIFICATION ; GENES ; EXPRESSION ; DISCOVERY ; LAEVIS
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Cited Times:18[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/20336
Collection鱼类生物学及渔业生物技术研究中心_期刊论文
AffiliationChinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
Recommended Citation
GB/T 7714
Zhu, Rong,Chen, Zhong-Yuan,Wang, Jun,et al. Thymus cDNA library survey uncovers novel features of immune molecules in Chinese giant salamander Andrias davidianus[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2014,46(2):413-422.
APA Zhu, Rong.,Chen, Zhong-Yuan.,Wang, Jun.,Yuan, Jiang-Di.,Liao, Xiang-Yong.,...&Zhang, Qi-Ya.(2014).Thymus cDNA library survey uncovers novel features of immune molecules in Chinese giant salamander Andrias davidianus.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,46(2),413-422.
MLA Zhu, Rong,et al."Thymus cDNA library survey uncovers novel features of immune molecules in Chinese giant salamander Andrias davidianus".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 46.2(2014):413-422.
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