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题名: Thymus cDNA library survey uncovers novel features of immune molecules in Chinese giant salamander Andrias davidianus
作者: Zhu, Rong1; Chen, Zhong-Yuan1; Wang, Jun1; Yuan, Jiang-Di1; Liao, Xiang-Yong1; Gui, Jian-Fang1; Zhang, Qi-Ya1
关键词: Immune gene ; Immunoglobulin ; Chinese giant salamander Andrias davidianus ; Thymus cDNA library ; Ranavirus-induced
刊名: DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
发表日期: 2014-10-01
DOI: 10.1016/j.dci.2014.05.019
卷: 46, 期:2, 页:413-422
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Immunology ; Zoology
研究领域[WOS]: Immunology ; Zoology
英文摘要: A ranavirus-induced thymus cDNA library was constructed from Chinese giant salamander, the largest extant amphibian species. Among the 137 putative immune-related genes derived from this library, these molecules received particular focus: immunoglobulin heavy chains (IgM, IgD, and IgY), IFN-inducible protein 6 (IFI6), and T cell receptor beta chain (TCR beta). Several unusual features were uncovered: IgD displays a structure pattern distinct from those described for other amphibians by having only four constant domains plus a hinge region. A unique IgY form (IgY(Delta Fc)), previously undescribed in amphibians, is present in serum. Alternative splicing is observed to generate IgH diversification. IFI6 is newly-identified in amphibians, which occurs in two forms divergent in subcelluar distribution and antiviral activity. TCR beta immunoscope profile follows the typical vertebrate pattern, implying a polyclonal T cell repertoire. Collectively, the pioneering survey of ranavirus-induced thymus cDNA library from Chinese giant salamander reveals immune components and characteristics in this primitive amphibian. (C) 2014 Elsevier Ltd. All rights reserved.
关键词[WOS]: IMMUNOGLOBULIN HEAVY-CHAIN ; EXTENSIVE DIVERSIFICATION ; XENOPUS-TROPICALIS ; AMPHIBIAN XENOPUS ; IGD ; IDENTIFICATION ; GENES ; EXPRESSION ; DISCOVERY ; LAEVIS
语种: 英语
WOS记录号: WOS:000340216600032
ISSN号: 0145-305X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/20336
Appears in Collections:鱼类生物学及渔业生物技术研究中心_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China

Recommended Citation:
Zhu, Rong; Chen, Zhong-Yuan; Wang, Jun; Yuan, Jiang-Di; Liao, Xiang-Yong; Gui, Jian-Fang; Zhang, Qi-Ya.Thymus cDNA library survey uncovers novel features of immune molecules in Chinese giant salamander Andrias davidianus,DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2014,():
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