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Fish viperin exerts a conserved antiviral function through RLR-triggered IFN signaling pathway
Wang, Bing; Zhang, Yi-Bing; Liu, Ting-Kai; Shi, Jun; Sun, Fan; Gui, Jian-Fang
2014-11-01
Source PublicationDEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
ISSN0145-305X
Volume47Issue:1Pages:140-149
AbstractMammalian viperin is a typical interferon (IFN)-induced antiviral protein. Fish have viperin homologs; however, little is known about the expression regulation of fish viperins. In this study, we report the expression regulation and antiviral function of a fish viperin from crucian carp Carassius auratus during IFN response. Crucian carp viperin is induced at mRNA and protein levels by fish IFNs and IFN stimuli such as poly(I:C). Consistently, this gene promoter contains multiple transcription factor binding sites including IFN-stimulated response elements (ISRE) and IFN gamma activation sequences (GAS), and is activated by two types of fish IFNs and also by the intracellular and extracellular poly(I:C). Activation of crucian carp viperin promoter by the intracellular poly(I:C) is mediated by retinoic acid-inducing gene I (RIG-I)-like receptors (RLR)-triggered IFN signaling pathway, which is further verified by the findings that each signaling molecule of RLR pathway is able to induce the expression of crucian carp viperin at mRNA and protein levels. Finally, overexpression of crucian carp viperin in cultured fish cells confers significant protection against infection of grass carp reovirus (GCRV). These data suggest that similar to mammalian homologs, crucian carp viperin exerts a conserved function through RLR-triggered IFN signaling pathway. (C) 2014 Elsevier Ltd. All rights reserved.
SubtypeArticle
KeywordViperin Carassius Auratus Ifn Inducible Protein Promoter Analysis Rlr Signaling Pathway Antiviral Function
DOI10.1016/j.dci.2014.07.006
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Language英语
WOS Research AreaImmunology ; Zoology
WOS SubjectImmunology ; Zoology
WOS IDWOS:000342275400017
WOS KeywordINNATE IMMUNE-RESPONSE ; CARP CARASSIUS-AURATUS ; TROUT ONCORHYNCHUS-MYKISS ; DEPENDENT PROTEIN-KINASE ; HEPATITIS-C VIRUS ; GENE-EXPRESSION ; SUBCELLULAR-LOCALIZATION ; HUMAN CYTOMEGALOVIRUS ; MOLECULAR-CLONING ; DENDRITIC CELLS
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Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/20330
Collection鱼类生物学及渔业生物技术研究中心_期刊论文
AffiliationUniv Chinese Acad Sci, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
Recommended Citation
GB/T 7714
Wang, Bing,Zhang, Yi-Bing,Liu, Ting-Kai,et al. Fish viperin exerts a conserved antiviral function through RLR-triggered IFN signaling pathway[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2014,47(1):140-149.
APA Wang, Bing,Zhang, Yi-Bing,Liu, Ting-Kai,Shi, Jun,Sun, Fan,&Gui, Jian-Fang.(2014).Fish viperin exerts a conserved antiviral function through RLR-triggered IFN signaling pathway.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,47(1),140-149.
MLA Wang, Bing,et al."Fish viperin exerts a conserved antiviral function through RLR-triggered IFN signaling pathway".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 47.1(2014):140-149.
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