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Tissue-specific derepression of TCF/LEF controls the activity of the Wnt/beta-catenin pathway
Lu, Fu-I1,2; Sun, Yong-Hua3,4; Wei, Chang-Yong4,5; Thisse, Christine1,3; Thisse, Bernard1,3
2014-11-01
Source PublicationNATURE COMMUNICATIONS
ISSN2041-1723
Volume5Issue:-
AbstractUpon stimulation by Wnt ligands, the canonical Wnt/beta-catenin signalling pathway results in the stabilization of beta-catenin and its translocation into the nucleus to form transcriptionally active complexes with sequence-specific DNA-binding T-cell factor/lymphoid enhancer factor (TCF/LEF) family proteins. In the absence of nuclear beta-catenin, TCF proteins act as transcriptional repressors by binding to Groucho/Transducin-Like Enhancer of split (TLE) proteins that function as co-repressors by interacting with histone deacetylases whose activity leads to the generation of transcriptionally silent chromatin. Here we show that the transcription factor Ladybird homeobox 2 (Lbx2) positively controls the Wnt/beta-catenin signalling pathway in the posterior lateral and ventral mesoderm of the zebrafish embryo at the gastrula stage, by directly interfering with the binding of Groucho/TLE to TCF, thereby preventing formation of transcription repressor complexes. These findings reveal a novel level of regulation of the canonical Wnt/beta-catenin signalling pathway occurring in the nucleus and involving tissue-specific derepression of TCF by Lbx2.
SubtypeArticle
KeywordBeta-catenin Zebrafish Wnt8 Co-repressors Self-renewal Groucho Transcription Gene Activation Mesoderm Tcf3
DOI10.1038/ncomms6368
WOS HeadingsScience & Technology
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000345655100008
WOS KeywordBETA-CATENIN ; ZEBRAFISH WNT8 ; CO-REPRESSORS ; SELF-RENEWAL ; GROUCHO ; TRANSCRIPTION ; GENE ; ACTIVATION ; MESODERM ; TCF3
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Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/20328
Collection鱼类生物学及渔业生物技术研究中心_期刊论文
Affiliation1.Univ Virginia, Dept Cell Biol, Charlottesville, VA 22908 USA
2.Natl Cheng Kung Univ, Inst Biotechnol, Tainan 701, Taiwan
3.Univ Strasbourg, CNRS, INSERM, Inst Genet & Biol Mol & Cellulaire, F-67400 Illkirch Graffenstaden, France
4.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Lu, Fu-I,Sun, Yong-Hua,Wei, Chang-Yong,et al. Tissue-specific derepression of TCF/LEF controls the activity of the Wnt/beta-catenin pathway[J]. NATURE COMMUNICATIONS,2014,5(-).
APA Lu, Fu-I,Sun, Yong-Hua,Wei, Chang-Yong,Thisse, Christine,&Thisse, Bernard.(2014).Tissue-specific derepression of TCF/LEF controls the activity of the Wnt/beta-catenin pathway.NATURE COMMUNICATIONS,5(-).
MLA Lu, Fu-I,et al."Tissue-specific derepression of TCF/LEF controls the activity of the Wnt/beta-catenin pathway".NATURE COMMUNICATIONS 5.-(2014).
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