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题名: Tissue-specific derepression of TCF/LEF controls the activity of the Wnt/beta-catenin pathway
作者: Lu, Fu-I1, 2; Sun, Yong-Hua3, 4; Wei, Chang-Yong4, 5; Thisse, Christine1, 3; Thisse, Bernard1, 3
关键词: BETA-CATENIN ; ZEBRAFISH WNT8 ; CO-REPRESSORS ; SELF-RENEWAL ; GROUCHO ; TRANSCRIPTION ; GENE ; ACTIVATION ; MESODERM ; TCF3
刊名: NATURE COMMUNICATIONS
发表日期: 2014-11-01
DOI: 10.1038/ncomms6368
卷: 5, 期:-
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
英文摘要: Upon stimulation by Wnt ligands, the canonical Wnt/beta-catenin signalling pathway results in the stabilization of beta-catenin and its translocation into the nucleus to form transcriptionally active complexes with sequence-specific DNA-binding T-cell factor/lymphoid enhancer factor (TCF/LEF) family proteins. In the absence of nuclear beta-catenin, TCF proteins act as transcriptional repressors by binding to Groucho/Transducin-Like Enhancer of split (TLE) proteins that function as co-repressors by interacting with histone deacetylases whose activity leads to the generation of transcriptionally silent chromatin. Here we show that the transcription factor Ladybird homeobox 2 (Lbx2) positively controls the Wnt/beta-catenin signalling pathway in the posterior lateral and ventral mesoderm of the zebrafish embryo at the gastrula stage, by directly interfering with the binding of Groucho/TLE to TCF, thereby preventing formation of transcription repressor complexes. These findings reveal a novel level of regulation of the canonical Wnt/beta-catenin signalling pathway occurring in the nucleus and involving tissue-specific derepression of TCF by Lbx2.
关键词[WOS]: BETA-CATENIN ; ZEBRAFISH WNT8 ; CO-REPRESSORS ; SELF-RENEWAL ; GROUCHO ; TRANSCRIPTION ; GENE ; ACTIVATION ; MESODERM ; TCF3
语种: 英语
WOS记录号: WOS:000345655100008
ISSN号: 2041-1723
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/20328
Appears in Collections:鱼类生物学及渔业生物技术研究中心_期刊论文

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作者单位: 1.Univ Virginia, Dept Cell Biol, Charlottesville, VA 22908 USA
2.Natl Cheng Kung Univ, Inst Biotechnol, Tainan 701, Taiwan
3.Univ Strasbourg, CNRS, INSERM, Inst Genet & Biol Mol & Cellulaire, F-67400 Illkirch Graffenstaden, France
4.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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文件名: 2014 Nat Comm.pdf
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