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题名: Organ-dependent response in antioxidants, myoglobin and neuroglobin in goldfish (Carassius auratus) exposed to MC-RR under varying oxygen level
作者: Okogwu, Okechukwu Idumah1, 2; Xie, Ping2; Zhao, Yanyan2; Fan, Huihui2
关键词: Antioxidant ; Goldfish ; Hypoxia ; Microcystin-RR ; Myoglobin ; Neuroglobin
刊名: CHEMOSPHERE
发表日期: 2014-10-01
DOI: 10.1016/j.chemosphere.2014.05.011
卷: 112, 期:-, 页:427-434
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Environmental Sciences
研究领域[WOS]: Environmental Sciences & Ecology
英文摘要: Cyanobacterial bloom, a common phenomenon nowadays often results in the depletion of dissolved oxygen (hypoxia) and releases microcystin-RR (MC-RR) in the water. Information on the combined effects of MC-RR and hypoxia on the goldfish is lacking, therefore, this study is aimed at evaluating the effect of two doses of MC-RR on the antioxidants and globin mRNA of goldfish under normoxia, hypoxia and reoxygenation. The result showed that MC-RR at both doses (50 and 200 mu g kg(-1) body weight) significantly (p < 0.05) induced superoxide dismutase activities in the liver and kidney but catalase activities and total antioxidant capacity were low in these organs during hypoxia and reoxygenation compared to normoxia and control. Myoglobin and neuroglobin mRNAs in MC-RR group were significantly induced in the brain only and are believed to protect the brain from oxidative damage. However, other organs were unprotected and extensive damage was observed in the liver cells. Our results clearly demonstrated that MC-RR and hypoxia-reoxygenation transitions were synergistically harmful to the goldfish and could impair its adaptation to hypoxia, especially during reoxygenation. (C) 2014 Elsevier Ltd. All rights reserved.
关键词[WOS]: OXIDATIVE STRESS ; MICROCYSTIN-LR ; IN-VIVO ; HYPOXIA ; LIVER ; PROTEIN ; GENES ; TRANSCRIPTION ; HEPATOCYTES ; EXPRESSION
语种: 英语
WOS记录号: WOS:000340688300056
ISSN号: 0045-6535
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/20306
Appears in Collections:淡水生态学研究中心_期刊论文

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作者单位: 1.Ebonyi State Univ, Dept Appl Biol, Abakaliki, Ebonyi State, Nigeria
2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosystems, Wuhan, Peoples R China
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