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Organ-dependent response in antioxidants, myoglobin and neuroglobin in goldfish (Carassius auratus) exposed to MC-RR under varying oxygen level
Okogwu, Okechukwu Idumah1,2; Xie, Ping2; Zhao, Yanyan2; Fan, Huihui2
2014-10-01
Source PublicationCHEMOSPHERE
ISSN0045-6535
Volume112Issue:-Pages:427-434
AbstractCyanobacterial bloom, a common phenomenon nowadays often results in the depletion of dissolved oxygen (hypoxia) and releases microcystin-RR (MC-RR) in the water. Information on the combined effects of MC-RR and hypoxia on the goldfish is lacking, therefore, this study is aimed at evaluating the effect of two doses of MC-RR on the antioxidants and globin mRNA of goldfish under normoxia, hypoxia and reoxygenation. The result showed that MC-RR at both doses (50 and 200 mu g kg(-1) body weight) significantly (p < 0.05) induced superoxide dismutase activities in the liver and kidney but catalase activities and total antioxidant capacity were low in these organs during hypoxia and reoxygenation compared to normoxia and control. Myoglobin and neuroglobin mRNAs in MC-RR group were significantly induced in the brain only and are believed to protect the brain from oxidative damage. However, other organs were unprotected and extensive damage was observed in the liver cells. Our results clearly demonstrated that MC-RR and hypoxia-reoxygenation transitions were synergistically harmful to the goldfish and could impair its adaptation to hypoxia, especially during reoxygenation. (C) 2014 Elsevier Ltd. All rights reserved.
SubtypeArticle
KeywordAntioxidant Goldfish Hypoxia Microcystin-rr Myoglobin Neuroglobin
DOI10.1016/j.chemosphere.2014.05.011
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Language英语
WOS Research AreaEnvironmental Sciences & Ecology
WOS SubjectEnvironmental Sciences
WOS IDWOS:000340688300056
WOS KeywordOXIDATIVE STRESS ; MICROCYSTIN-LR ; IN-VIVO ; HYPOXIA ; LIVER ; PROTEIN ; GENES ; TRANSCRIPTION ; HEPATOCYTES ; EXPRESSION
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/20306
Collection淡水生态学研究中心_期刊论文
Affiliation1.Ebonyi State Univ, Dept Appl Biol, Abakaliki, Ebonyi State, Nigeria
2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosystems, Wuhan, Peoples R China
Recommended Citation
GB/T 7714
Okogwu, Okechukwu Idumah,Xie, Ping,Zhao, Yanyan,et al. Organ-dependent response in antioxidants, myoglobin and neuroglobin in goldfish (Carassius auratus) exposed to MC-RR under varying oxygen level[J]. CHEMOSPHERE,2014,112(-):427-434.
APA Okogwu, Okechukwu Idumah,Xie, Ping,Zhao, Yanyan,&Fan, Huihui.(2014).Organ-dependent response in antioxidants, myoglobin and neuroglobin in goldfish (Carassius auratus) exposed to MC-RR under varying oxygen level.CHEMOSPHERE,112(-),427-434.
MLA Okogwu, Okechukwu Idumah,et al."Organ-dependent response in antioxidants, myoglobin and neuroglobin in goldfish (Carassius auratus) exposed to MC-RR under varying oxygen level".CHEMOSPHERE 112.-(2014):427-434.
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