中国科学院水生生物研究所机构知识库
Advanced  
IHB OpenIR  > 水生生物分子与细胞生物学研究中心  > 期刊论文
题名: Generation of "Virtual" Control Groups for Single Arm Prostate Cancer Adjuvant Trials
作者: Jia, Zhenyu1, 10, 17; Lilly, Michael B.2; Koziol, James A.3; Chen, Xin4; Xia, Xiao-Qin5; Wang, Yipeng6; Skarecky, Douglas7; Sutton, Manuel4; Sawyers, Anne4; Ruckle, Herbert8; Carpenter, Philip M.4; Wang-Rodriguez, Jessica9; Jiang, Jun10; Deng, Mingsen10; Pan, Cong10; Zhu, Jian-guo10, 11; McLaren, Christine E.12; Gurley, Michael J.13; Lee, Chung1, 13; McClelland, Michael14, 15; Ahlering, Thomas7; Kattan, Michael W.16; Mercola, Dan4
通讯作者: Jia, ZY (reprint author), Univ Akron, Dept Stat, Akron, OH 44325 USA.
关键词: RADICAL PROSTATECTOMY ; POSTOPERATIVE NOMOGRAMS ; PREOPERATIVE NOMOGRAM ; 10-YEAR PROBABILITY ; DISEASE RECURRENCE ; CLINICAL-TRIAL ; FOLLOW-UP ; HIGH-RISK ; DOCETAXEL ; EFFICACY
刊名: PLOS ONE
发表日期: 2014-01-21
DOI: 10.1371/journal.pone.0085010
卷: 9, 期:1, 页:e85010
收录类别: SCI
文章类型: Article
部门归属: [Jia, Zhenyu; Lee, Chung] Univ Akron, Dept Stat, Akron, OH 44325 USA; [Lilly, Michael B.] Med Univ S Carolina, Div Hematol Oncol, Charleston, SC 29425 USA; [Koziol, James A.] Ashford Univ, Coll Hlth Human Serv & Sci, San Diego, CA 92128 USA; [Chen, Xin; Sutton, Manuel; Sawyers, Anne; Carpenter, Philip M.; Mercola, Dan] Univ Calif Irvine, Dept Pathol & Lab Med, Irvine, CA USA; [Xia, Xiao-Qin] Chinese Acad Sci, Inst Hydrobiol, Wuhan, Peoples R China; [Wang, Yipeng] AltheaDx Inc, San Diego, CA USA; [Skarecky, Douglas; Ahlering, Thomas] Univ Calif Irvine, Dept Urol, Irvine, CA USA; [Ruckle, Herbert] Loma Linda Univ, Dept Urol, Loma Linda, CA 92350 USA; [Wang-Rodriguez, Jessica] Univ Calif San Diego, Dept Pathol, La Jolla, CA 92093 USA; [Jia, Zhenyu; Jiang, Jun; Deng, Mingsen; Pan, Cong; Zhu, Jian-guo] Guizhou Normal Coll, Guizhou Prov Key Lab Computat Nanomat Sci, Guiyang, Peoples R China; [Zhu, Jian-guo] Guizhou Prov Peoples Hosp, Dept Urol, Guiyang, Guizhou, Peoples R China; [McLaren, Christine E.] Univ Calif Irvine, Dept Epidemiol, Irvine, CA USA; [Gurley, Michael J.; Lee, Chung] Northwestern Univ, Dept Urol, Feinberg Sch Med, Chicago, IL 60611 USA; [McClelland, Michael] Univ Calif Irvine, Dept Med, Irvine, CA 92717 USA; [McClelland, Michael] Vaccine Res Inst San Diego, San Diego, CA USA; [Kattan, Michael W.] Cleveland Clin, Dept Quantitat Hlth Sci, Cleveland, OH 44106 USA; [Jia, Zhenyu] Northeast Ohio Med Univ, Dept Family & Community Med, Rootstown, OH USA
WOS标题词: Science & Technology
资助者: United States National Institutes of Health [NCI UO1CA11480, NCI UO1CA152738]; University of California Irvine Faculty Career Development Award; University of California Chao Family Comprehensive Cancer Center Seed Grant; National Cancer Institute [P30CA062203]; CDMRP [W81XWH-08-1-0720]
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
摘要: It is difficult to construct a control group for trials of adjuvant therapy (Rx) of prostate cancer after radical prostatectomy (RP) due to ethical issues and patient acceptance. We utilized 8 curve-fitting models to estimate the time to 60%, 65%, ... 95% chance of progression free survival (PFS) based on the data derived from Kattan post-RP nomogram. The 8 models were systematically applied to a training set of 153 post-RP cases without adjuvant Rx to develop 8 subsets of cases (reference case sets) whose observed PFS times were most accurately predicted by each model. To prepare a virtual control group for a single-arm adjuvant Rx trial, we first select the optimal model for the trial cases based on the minimum weighted Euclidean distance between the trial case set and the reference case set in terms of clinical features, and then compare the virtual PFS times calculated by the optimum model with the observed PFSs of the trial cases by the logrank test. The method was validated using an independent dataset of 155 post-RP patients without adjuvant Rx. We then applied the method to patients on a Phase II trial of adjuvant chemo-hormonal Rx post RP, which indicated that the adjuvant Rx is highly effective in prolonging PFS after RP in patients at high risk for prostate cancer recurrence. The method can accurately generate control groups for single-arm, post-RP adjuvant Rx trials for prostate cancer, facilitating development of new therapeutic strategies.
英文摘要: It is difficult to construct a control group for trials of adjuvant therapy (Rx) of prostate cancer after radical prostatectomy (RP) due to ethical issues and patient acceptance. We utilized 8 curve-fitting models to estimate the time to 60%, 65%, ... 95% chance of progression free survival (PFS) based on the data derived from Kattan post-RP nomogram. The 8 models were systematically applied to a training set of 153 post-RP cases without adjuvant Rx to develop 8 subsets of cases (reference case sets) whose observed PFS times were most accurately predicted by each model. To prepare a virtual control group for a single-arm adjuvant Rx trial, we first select the optimal model for the trial cases based on the minimum weighted Euclidean distance between the trial case set and the reference case set in terms of clinical features, and then compare the virtual PFS times calculated by the optimum model with the observed PFSs of the trial cases by the logrank test. The method was validated using an independent dataset of 155 post-RP patients without adjuvant Rx. We then applied the method to patients on a Phase II trial of adjuvant chemo-hormonal Rx post RP, which indicated that the adjuvant Rx is highly effective in prolonging PFS after RP in patients at high risk for prostate cancer recurrence. The method can accurately generate control groups for single-arm, post-RP adjuvant Rx trials for prostate cancer, facilitating development of new therapeutic strategies.
关键词[WOS]: LOCALLY WEIGHTED REGRESSION ; RADICAL PROSTATECTOMY ; POSTOPERATIVE NOMOGRAMS ; SMOOTHING SCATTERPLOTS ; PREOPERATIVE NOMOGRAM ; 10-YEAR PROBABILITY ; DISEASE RECURRENCE ; CLINICAL-TRIAL ; FOLLOW-UP ; HIGH-RISK
语种: 英语
WOS记录号: WOS:000330244500028
ISSN号: 1932-6203
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/20098
Appears in Collections:水生生物分子与细胞生物学研究中心_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
Generation of Virtual Control Groups or Single Arm Prostate Cancer Adjuvant Trials.pdf(2022KB)----开放获取View Download

作者单位: 1.Univ Akron, Dept Stat, Akron, OH 44325 USA
2.Med Univ S Carolina, Div Hematol Oncol, Charleston, SC 29425 USA
3.Ashford Univ, Coll Hlth Human Serv & Sci, San Diego, CA 92128 USA
4.Univ Calif Irvine, Dept Pathol & Lab Med, Irvine, CA USA
5.Chinese Acad Sci, Inst Hydrobiol, Wuhan, Peoples R China
6.AltheaDx Inc, San Diego, CA USA
7.Univ Calif Irvine, Dept Urol, Irvine, CA USA
8.Loma Linda Univ, Dept Urol, Loma Linda, CA 92350 USA
9.Univ Calif San Diego, Dept Pathol, La Jolla, CA 92093 USA
10.Guizhou Normal Coll, Guizhou Prov Key Lab Computat Nanomat Sci, Guiyang, Peoples R China
11.Guizhou Prov Peoples Hosp, Dept Urol, Guiyang, Guizhou, Peoples R China
12.Univ Calif Irvine, Dept Epidemiol, Irvine, CA USA
13.Northwestern Univ, Dept Urol, Feinberg Sch Med, Chicago, IL 60611 USA
14.Univ Calif Irvine, Dept Med, Irvine, CA 92717 USA
15.Vaccine Res Inst San Diego, San Diego, CA USA
16.Cleveland Clin, Dept Quantitat Hlth Sci, Cleveland, OH 44106 USA
17.Northeast Ohio Med Univ, Dept Family & Community Med, Rootstown, OH USA
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Jia, Zhenyu]'s Articles
[Lilly, Michael B.]'s Articles
[Koziol, James A.]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Jia, Zhenyu]‘s Articles
[Lilly, Michael B.]‘s Articles
[Koziol, James A.]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Generation of Virtual Control Groups or Single Arm Prostate Cancer Adjuvant Trials.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2016  中国科学院水生生物研究所 - Feedback
Powered by CSpace