中国科学院水生生物研究所机构知识库
Advanced  
IHB OpenIR  > 水生生物分子与细胞生物学研究中心  > 期刊论文
题名: Defenses of susceptible and resistant Chinook salmon (Onchorhynchus tshawytscha) against the myxozoan parasite Ceratomyxa shasta
作者: Bjork, Sarah J.1; Zhang, Yong-An2, 3; Hurst, Charlene N.1; Alonso-Naveiro, Maria E.4; Alexander, Julie D.1; Sunyer, J. Oriol3; Bartholomew, Jerri L.1
通讯作者: Bartholomew, JL (reprint author), Oregon State Univ, Dept Microbiol, Corvallis, OR 97331 USA.
关键词: Resistance ; Immune response ; Inflammation ; Cytokine ; Myxozoa
刊名: FISH & SHELLFISH IMMUNOLOGY
发表日期: 2014-03-01
DOI: 10.1016/j.fsi.2013.12.024
卷: 37, 期:1, 页:87-95
收录类别: SCI
文章类型: Article
部门归属: [Bjork, Sarah J.; Hurst, Charlene N.; Alexander, Julie D.; Bartholomew, Jerri L.] Oregon State Univ, Dept Microbiol, Corvallis, OR 97331 USA; [Zhang, Yong-An] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hunan, Peoples R China; [Zhang, Yong-An; Sunyer, J. Oriol] Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA; [Alonso-Naveiro, Maria E.] IATS CSIC, Castellon de La Plana 12595, Spain
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
资助者: Oregon Sea Grant [R/RCF-24]; U.S. Department of Commerce National Oceanic and Atmospheric Administration's National Sea Grant College Program [NA060AR4170010]; National Science Foundation [NSF-IOS-1022300 MCB-0719599]; National Institutes of Health [R01GM085207]
类目[WOS]: Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
研究领域[WOS]: Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
摘要: We investigated intra-specific variation in the response of salmon to infection with the myxozoan Ceratomyxa shasta by comparing the progress of parasite infection and measures of host immune response in susceptible and resistant Chinook salmon Oncorhynchus tshawytscha at days 12, 25 and 90 post exposure. There were no differences in invasion of the gills indicating that resistance does not occur at the site of entry. In the intestine on day 12, infection intensity and Ig(+) cell numbers were higher in susceptible than resistant fish, but histological examination at that timepoint showed more severe inflammation in resistant fish. This suggests a role for the immune response in resistant fish that eliminates some parasites prior to or soon after reaching the intestine. Susceptible fish had a higher IFN gamma, IL-6 and IL-10 response at day 12, but all died of fatal enteronecrosis by day 25. The greatest fold change in IFN gamma expression was detected at day 25 in resistant Chinook. In addition, the number of Ig(+) cells in resistant Chinook also increased by day 25. By day 90, resistant Chinook had resolved the inflammation, cytokine expression had decreased and Ig(+) cell numbers were similar to uninfected controls. Thus, it appears that the susceptible strain was incapable of containing or eliminating C shasta but resistant fish: 1) reduced infection intensity during early intestinal infection, 2) elicited an effective inflammatory response in the intestine that eliminated C. shasta, 3) resolved the inflammation and recovered from infection. (C) 2014 Elsevier Ltd. All rights reserved.
英文摘要: We investigated intra-specific variation in the response of salmon to infection with the myxozoan Ceratomyxa shasta by comparing the progress of parasite infection and measures of host immune response in susceptible and resistant Chinook salmon Oncorhynchus tshawytscha at days 12, 25 and 90 post exposure. There were no differences in invasion of the gills indicating that resistance does not occur at the site of entry. In the intestine on day 12, infection intensity and Ig(+) cell numbers were higher in susceptible than resistant fish, but histological examination at that timepoint showed more severe inflammation in resistant fish. This suggests a role for the immune response in resistant fish that eliminates some parasites prior to or soon after reaching the intestine. Susceptible fish had a higher IFN gamma, IL-6 and IL-10 response at day 12, but all died of fatal enteronecrosis by day 25. The greatest fold change in IFN gamma expression was detected at day 25 in resistant Chinook. In addition, the number of Ig(+) cells in resistant Chinook also increased by day 25. By day 90, resistant Chinook had resolved the inflammation, cytokine expression had decreased and Ig(+) cell numbers were similar to uninfected controls. Thus, it appears that the susceptible strain was incapable of containing or eliminating C shasta but resistant fish: 1) reduced infection intensity during early intestinal infection, 2) elicited an effective inflammatory response in the intestine that eliminated C. shasta, 3) resolved the inflammation and recovered from infection. (C) 2014 Elsevier Ltd. All rights reserved.
关键词[WOS]: PROLIFERATIVE KIDNEY-DISEASE ; ENTEROMYXUM-LEEI MYXOZOA ; TROUT ONCORHYNCHUS-MYKISS ; KLAMATH RIVER-BASIN ; RAINBOW-TROUT ; MYXOSPOREAN PARASITE ; IMMUNE-RESPONSE ; COHO SALMON ; ANTIBODY-PRODUCTION ; WATER TEMPERATURE
语种: 英语
WOS记录号: WOS:000333717100011
ISSN号: 1050-4648
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/20091
Appears in Collections:水生生物分子与细胞生物学研究中心_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
Defenses of susceptible and resistant Chinook salmon (Onchorhynchus tshawytscha) against the myxozoan parasite Ceratomyxa shasta.pdf(4180KB)----开放获取View 联系获取全文

作者单位: 1.Oregon State Univ, Dept Microbiol, Corvallis, OR 97331 USA
2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hunan, Peoples R China
3.Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA
4.IATS CSIC, Castellon de La Plana 12595, Spain

Recommended Citation:
Bjork, Sarah J.; Zhang, Yong-An; Hurst, Charlene N.; Alonso-Naveiro, Maria E.; Alexander, Julie D.; Sunyer, J. Oriol; Bartholomew, Jerri L..Defenses of susceptible and resistant Chinook salmon (Onchorhynchus tshawytscha) against the myxozoan parasite Ceratomyxa shasta,FISH & SHELLFISH IMMUNOLOGY,2014,37(1):87-95
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Bjork, Sarah J.]'s Articles
[Zhang, Yong-An]'s Articles
[Hurst, Charlene N.]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Bjork, Sarah J.]‘s Articles
[Zhang, Yong-An]‘s Articles
[Hurst, Charlene N.]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Defenses of susceptible and resistant Chinook salmon (Onchorhynchus tshawytscha) against the myxozoan parasite Ceratomyxa shasta.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2016  中国科学院水生生物研究所 - Feedback
Powered by CSpace