IHB OpenIR  > 水生生物分子与细胞生物学研究中心  > 期刊论文
Defenses of susceptible and resistant Chinook salmon (Onchorhynchus tshawytscha) against the myxozoan parasite Ceratomyxa shasta
Bjork, Sarah J.1; Zhang, Yong-An2,3; Hurst, Charlene N.1; Alonso-Naveiro, Maria E.4; Alexander, Julie D.1; Sunyer, J. Oriol3; Bartholomew, Jerri L.1; Bartholomew, JL (reprint author), Oregon State Univ, Dept Microbiol, Corvallis, OR 97331 USA.
2014-03-01
Source PublicationFISH & SHELLFISH IMMUNOLOGY
ISSN1050-4648
Volume37Issue:1Pages:87-95
AbstractWe investigated intra-specific variation in the response of salmon to infection with the myxozoan Ceratomyxa shasta by comparing the progress of parasite infection and measures of host immune response in susceptible and resistant Chinook salmon Oncorhynchus tshawytscha at days 12, 25 and 90 post exposure. There were no differences in invasion of the gills indicating that resistance does not occur at the site of entry. In the intestine on day 12, infection intensity and Ig(+) cell numbers were higher in susceptible than resistant fish, but histological examination at that timepoint showed more severe inflammation in resistant fish. This suggests a role for the immune response in resistant fish that eliminates some parasites prior to or soon after reaching the intestine. Susceptible fish had a higher IFN gamma, IL-6 and IL-10 response at day 12, but all died of fatal enteronecrosis by day 25. The greatest fold change in IFN gamma expression was detected at day 25 in resistant Chinook. In addition, the number of Ig(+) cells in resistant Chinook also increased by day 25. By day 90, resistant Chinook had resolved the inflammation, cytokine expression had decreased and Ig(+) cell numbers were similar to uninfected controls. Thus, it appears that the susceptible strain was incapable of containing or eliminating C shasta but resistant fish: 1) reduced infection intensity during early intestinal infection, 2) elicited an effective inflammatory response in the intestine that eliminated C. shasta, 3) resolved the inflammation and recovered from infection. (C) 2014 Elsevier Ltd. All rights reserved.; We investigated intra-specific variation in the response of salmon to infection with the myxozoan Ceratomyxa shasta by comparing the progress of parasite infection and measures of host immune response in susceptible and resistant Chinook salmon Oncorhynchus tshawytscha at days 12, 25 and 90 post exposure. There were no differences in invasion of the gills indicating that resistance does not occur at the site of entry. In the intestine on day 12, infection intensity and Ig(+) cell numbers were higher in susceptible than resistant fish, but histological examination at that timepoint showed more severe inflammation in resistant fish. This suggests a role for the immune response in resistant fish that eliminates some parasites prior to or soon after reaching the intestine. Susceptible fish had a higher IFN gamma, IL-6 and IL-10 response at day 12, but all died of fatal enteronecrosis by day 25. The greatest fold change in IFN gamma expression was detected at day 25 in resistant Chinook. In addition, the number of Ig(+) cells in resistant Chinook also increased by day 25. By day 90, resistant Chinook had resolved the inflammation, cytokine expression had decreased and Ig(+) cell numbers were similar to uninfected controls. Thus, it appears that the susceptible strain was incapable of containing or eliminating C shasta but resistant fish: 1) reduced infection intensity during early intestinal infection, 2) elicited an effective inflammatory response in the intestine that eliminated C. shasta, 3) resolved the inflammation and recovered from infection. (C) 2014 Elsevier Ltd. All rights reserved.
SubtypeArticle
KeywordResistance Immune Response Inflammation Cytokine Myxozoa
Department[Bjork, Sarah J.; Hurst, Charlene N.; Alexander, Julie D.; Bartholomew, Jerri L.] Oregon State Univ, Dept Microbiol, Corvallis, OR 97331 USA; [Zhang, Yong-An] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hunan, Peoples R China; [Zhang, Yong-An; Sunyer, J. Oriol] Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA; [Alonso-Naveiro, Maria E.] IATS CSIC, Castellon de La Plana 12595, Spain
DOI10.1016/j.fsi.2013.12.024
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Funding OrganizationOregon Sea Grant [R/RCF-24]; U.S. Department of Commerce National Oceanic and Atmospheric Administration's National Sea Grant College Program [NA060AR4170010]; National Science Foundation [NSF-IOS-1022300 MCB-0719599]; National Institutes of Health [R01GM085207] ; Oregon Sea Grant [R/RCF-24]; U.S. Department of Commerce National Oceanic and Atmospheric Administration's National Sea Grant College Program [NA060AR4170010]; National Science Foundation [NSF-IOS-1022300 MCB-0719599]; National Institutes of Health [R01GM085207] ; Oregon Sea Grant [R/RCF-24]; U.S. Department of Commerce National Oceanic and Atmospheric Administration's National Sea Grant College Program [NA060AR4170010]; National Science Foundation [NSF-IOS-1022300 MCB-0719599]; National Institutes of Health [R01GM085207] ; Oregon Sea Grant [R/RCF-24]; U.S. Department of Commerce National Oceanic and Atmospheric Administration's National Sea Grant College Program [NA060AR4170010]; National Science Foundation [NSF-IOS-1022300 MCB-0719599]; National Institutes of Health [R01GM085207]
Indexed BySCI
Language英语
WOS Research AreaFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS SubjectFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS IDWOS:000333717100011
WOS KeywordPROLIFERATIVE KIDNEY-DISEASE ; ENTEROMYXUM-LEEI MYXOZOA ; TROUT ONCORHYNCHUS-MYKISS ; KLAMATH RIVER-BASIN ; RAINBOW-TROUT ; MYXOSPOREAN PARASITE ; IMMUNE-RESPONSE ; COHO SALMON ; ANTIBODY-PRODUCTION ; WATER TEMPERATURE
Funding OrganizationOregon Sea Grant [R/RCF-24]; U.S. Department of Commerce National Oceanic and Atmospheric Administration's National Sea Grant College Program [NA060AR4170010]; National Science Foundation [NSF-IOS-1022300 MCB-0719599]; National Institutes of Health [R01GM085207] ; Oregon Sea Grant [R/RCF-24]; U.S. Department of Commerce National Oceanic and Atmospheric Administration's National Sea Grant College Program [NA060AR4170010]; National Science Foundation [NSF-IOS-1022300 MCB-0719599]; National Institutes of Health [R01GM085207] ; Oregon Sea Grant [R/RCF-24]; U.S. Department of Commerce National Oceanic and Atmospheric Administration's National Sea Grant College Program [NA060AR4170010]; National Science Foundation [NSF-IOS-1022300 MCB-0719599]; National Institutes of Health [R01GM085207] ; Oregon Sea Grant [R/RCF-24]; U.S. Department of Commerce National Oceanic and Atmospheric Administration's National Sea Grant College Program [NA060AR4170010]; National Science Foundation [NSF-IOS-1022300 MCB-0719599]; National Institutes of Health [R01GM085207]
Citation statistics
Cited Times:18[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/20091
Collection水生生物分子与细胞生物学研究中心_期刊论文
Corresponding AuthorBartholomew, JL (reprint author), Oregon State Univ, Dept Microbiol, Corvallis, OR 97331 USA.
Affiliation1.Oregon State Univ, Dept Microbiol, Corvallis, OR 97331 USA
2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hunan, Peoples R China
3.Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA
4.IATS CSIC, Castellon de La Plana 12595, Spain
Recommended Citation
GB/T 7714
Bjork, Sarah J.,Zhang, Yong-An,Hurst, Charlene N.,et al. Defenses of susceptible and resistant Chinook salmon (Onchorhynchus tshawytscha) against the myxozoan parasite Ceratomyxa shasta[J]. FISH & SHELLFISH IMMUNOLOGY,2014,37(1):87-95.
APA Bjork, Sarah J..,Zhang, Yong-An.,Hurst, Charlene N..,Alonso-Naveiro, Maria E..,Alexander, Julie D..,...&Bartholomew, JL .(2014).Defenses of susceptible and resistant Chinook salmon (Onchorhynchus tshawytscha) against the myxozoan parasite Ceratomyxa shasta.FISH & SHELLFISH IMMUNOLOGY,37(1),87-95.
MLA Bjork, Sarah J.,et al."Defenses of susceptible and resistant Chinook salmon (Onchorhynchus tshawytscha) against the myxozoan parasite Ceratomyxa shasta".FISH & SHELLFISH IMMUNOLOGY 37.1(2014):87-95.
Files in This Item:
File Name/Size DocType Version Access License
Defenses of suscepti(4180KB) 开放获取CC BY-NC-SAView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Bjork, Sarah J.]'s Articles
[Zhang, Yong-An]'s Articles
[Hurst, Charlene N.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Bjork, Sarah J.]'s Articles
[Zhang, Yong-An]'s Articles
[Hurst, Charlene N.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Bjork, Sarah J.]'s Articles
[Zhang, Yong-An]'s Articles
[Hurst, Charlene N.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Defenses of susceptible and resistant Chinook salmon (Onchorhynchus tshawytscha) against the myxozoan parasite Ceratomyxa shasta.pdf
Format: Adobe PDF
This file does not support browsing at this time
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.