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题名: Prion protein and cancers
作者: Yang, Xiaowen1; Zhang, Yan2, 3; Zhang, Lihua4; He, Tianlin5; Zhang, Jie6; Li, Chaoyang3
通讯作者: Li, CY (reprint author), Chinese Acad Sci, State Key Lab Virol, Wuhan Inst Virol, Wuhan 430071, Peoples R China.
关键词: prion protein ; prion disease ; tumorigenesis
刊名: ACTA BIOCHIMICA ET BIOPHYSICA SINICA
发表日期: 2014-06-01
DOI: 10.1093/abbs/gmu019
卷: 46, 期:6, 页:431-440
收录类别: SCI
文章类型: Review
部门归属: [Yang, Xiaowen] Jiangxi Tumor Hosp, Dept Abdominal Surg 1, Nanchang 330029, Peoples R China; [Zhang, Yan] Chinese Acad Sci, Inst Hydrobiol, Dept Mol Endocrinol, Wuhan 430072, Peoples R China; [Zhang, Yan; Li, Chaoyang] Chinese Acad Sci, State Key Lab Virol, Wuhan Inst Virol, Wuhan 430071, Peoples R China; [Zhang, Lihua] Southeast Univ, Zhongda Hosp, Dept Pathol, Nanjing 210009, Peoples R China; [He, Tianlin] Second Mil Med Univ, Dept Gen Surg, Changhai Hosp, Shanghai 200433, Peoples R China; [Zhang, Jie] Shihezi Univ Med Coll, Affiliated Hosp 1, Dept Stomatol, Shihezi 832000, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
资助者: National Natural Science Foundation of China [81172376, 31270209]; Chinese Academy of Sciences
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
摘要: The normal cellular prion protein, PrPC is a highly conserved and widely expressed cell surface glycoprotein in all mammals. The expression of PrP is pivotal in the pathogenesis of prion diseases; however, the normal physiological functions of PrPC remain incompletely understood. Based on the studies in cell models, a plethora of functions have been attributed to PrPC. In this paper, we reviewed the potential roles that PrPC plays in cell physiology and focused on its contribution to tumorigenesis.
英文摘要: The normal cellular prion protein, PrPC is a highly conserved and widely expressed cell surface glycoprotein in all mammals. The expression of PrP is pivotal in the pathogenesis of prion diseases; however, the normal physiological functions of PrPC remain incompletely understood. Based on the studies in cell models, a plethora of functions have been attributed to PrPC. In this paper, we reviewed the potential roles that PrPC plays in cell physiology and focused on its contribution to tumorigenesis.
关键词[WOS]: NEURONAL CELL-SURFACE ; DISRUPTED PRP GENE ; NEURITE OUTGROWTH ; GASTRIC-CANCER ; SIGNAL-TRANSDUCTION ; TRANSGENIC MICE ; LYMPHOCYTE-ACTIVATION ; NEUROBLASTOMA-CELLS ; PANCREATIC-CANCER ; OXIDATIVE STRESS
语种: 英语
WOS记录号: WOS:000337029500001
ISSN号: 1672-9145
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/20075
Appears in Collections:水环境工程研究中心_期刊论文

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作者单位: 1.Jiangxi Tumor Hosp, Dept Abdominal Surg 1, Nanchang 330029, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, Dept Mol Endocrinol, Wuhan 430072, Peoples R China
3.Chinese Acad Sci, State Key Lab Virol, Wuhan Inst Virol, Wuhan 430071, Peoples R China
4.Southeast Univ, Zhongda Hosp, Dept Pathol, Nanjing 210009, Peoples R China
5.Second Mil Med Univ, Dept Gen Surg, Changhai Hosp, Shanghai 200433, Peoples R China
6.Shihezi Univ Med Coll, Affiliated Hosp 1, Dept Stomatol, Shihezi 832000, Peoples R China
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