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Prion protein and cancers
Yang, Xiaowen1; Zhang, Yan2,3; Zhang, Lihua4; He, Tianlin5; Zhang, Jie6; Li, Chaoyang3; Li, CY (reprint author), Chinese Acad Sci, State Key Lab Virol, Wuhan Inst Virol, Wuhan 430071, Peoples R China.
2014-06-01
Source PublicationACTA BIOCHIMICA ET BIOPHYSICA SINICA
ISSN1672-9145
Volume46Issue:6Pages:431-440
AbstractThe normal cellular prion protein, PrPC is a highly conserved and widely expressed cell surface glycoprotein in all mammals. The expression of PrP is pivotal in the pathogenesis of prion diseases; however, the normal physiological functions of PrPC remain incompletely understood. Based on the studies in cell models, a plethora of functions have been attributed to PrPC. In this paper, we reviewed the potential roles that PrPC plays in cell physiology and focused on its contribution to tumorigenesis.; The normal cellular prion protein, PrPC is a highly conserved and widely expressed cell surface glycoprotein in all mammals. The expression of PrP is pivotal in the pathogenesis of prion diseases; however, the normal physiological functions of PrPC remain incompletely understood. Based on the studies in cell models, a plethora of functions have been attributed to PrPC. In this paper, we reviewed the potential roles that PrPC plays in cell physiology and focused on its contribution to tumorigenesis.
SubtypeReview
KeywordPrion Protein Prion Disease Tumorigenesis
Department[Yang, Xiaowen] Jiangxi Tumor Hosp, Dept Abdominal Surg 1, Nanchang 330029, Peoples R China; [Zhang, Yan] Chinese Acad Sci, Inst Hydrobiol, Dept Mol Endocrinol, Wuhan 430072, Peoples R China; [Zhang, Yan; Li, Chaoyang] Chinese Acad Sci, State Key Lab Virol, Wuhan Inst Virol, Wuhan 430071, Peoples R China; [Zhang, Lihua] Southeast Univ, Zhongda Hosp, Dept Pathol, Nanjing 210009, Peoples R China; [He, Tianlin] Second Mil Med Univ, Dept Gen Surg, Changhai Hosp, Shanghai 200433, Peoples R China; [Zhang, Jie] Shihezi Univ Med Coll, Affiliated Hosp 1, Dept Stomatol, Shihezi 832000, Peoples R China
DOI10.1093/abbs/gmu019
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Funding OrganizationNational Natural Science Foundation of China [81172376, 31270209]; Chinese Academy of Sciences ; National Natural Science Foundation of China [81172376, 31270209]; Chinese Academy of Sciences ; National Natural Science Foundation of China [81172376, 31270209]; Chinese Academy of Sciences ; National Natural Science Foundation of China [81172376, 31270209]; Chinese Academy of Sciences
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Biophysics
WOS SubjectBiochemistry & Molecular Biology ; Biophysics
WOS IDWOS:000337029500001
WOS KeywordNEURONAL CELL-SURFACE ; DISRUPTED PRP GENE ; NEURITE OUTGROWTH ; GASTRIC-CANCER ; SIGNAL-TRANSDUCTION ; TRANSGENIC MICE ; LYMPHOCYTE-ACTIVATION ; NEUROBLASTOMA-CELLS ; PANCREATIC-CANCER ; OXIDATIVE STRESS
Funding OrganizationNational Natural Science Foundation of China [81172376, 31270209]; Chinese Academy of Sciences ; National Natural Science Foundation of China [81172376, 31270209]; Chinese Academy of Sciences ; National Natural Science Foundation of China [81172376, 31270209]; Chinese Academy of Sciences ; National Natural Science Foundation of China [81172376, 31270209]; Chinese Academy of Sciences
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Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/20075
Collection水环境工程研究中心_期刊论文
Corresponding AuthorLi, CY (reprint author), Chinese Acad Sci, State Key Lab Virol, Wuhan Inst Virol, Wuhan 430071, Peoples R China.
Affiliation1.Jiangxi Tumor Hosp, Dept Abdominal Surg 1, Nanchang 330029, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, Dept Mol Endocrinol, Wuhan 430072, Peoples R China
3.Chinese Acad Sci, State Key Lab Virol, Wuhan Inst Virol, Wuhan 430071, Peoples R China
4.Southeast Univ, Zhongda Hosp, Dept Pathol, Nanjing 210009, Peoples R China
5.Second Mil Med Univ, Dept Gen Surg, Changhai Hosp, Shanghai 200433, Peoples R China
6.Shihezi Univ Med Coll, Affiliated Hosp 1, Dept Stomatol, Shihezi 832000, Peoples R China
Recommended Citation
GB/T 7714
Yang, Xiaowen,Zhang, Yan,Zhang, Lihua,et al. Prion protein and cancers[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2014,46(6):431-440.
APA Yang, Xiaowen.,Zhang, Yan.,Zhang, Lihua.,He, Tianlin.,Zhang, Jie.,...&Li, CY .(2014).Prion protein and cancers.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,46(6),431-440.
MLA Yang, Xiaowen,et al."Prion protein and cancers".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 46.6(2014):431-440.
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