IHB OpenIR  > 水环境工程研究中心  > 期刊论文
The synthetic progestin megestrol acetate adversely affects zebrafish reproduction
Han, Jian1,2; Wang, Qiangwei1,2; Wang, Xianfeng1,2; Li, Yonggang3; Wen, Sheng3; Liu, Shan4; Ying, Guangguo5; Guo, Yongyong1; Zhou, Bingsheng1; Zhou, BS (reprint author), Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China.
2014-05-01
Source PublicationAQUATIC TOXICOLOGY
ISSN0166-445X
Volume150Pages:66-72
AbstractSynthetic progestins contaminate the aquatic ecosystem, and may cause adverse health effects on aquatic organisms. Megestrol acetate (MTA) is present in the aquatic environment, but its possible effects on fish reproduction are unknown. In the present study, we investigated the endocrine disruption and impact of MTA on fish reproduction. After a pre-exposure period of 14 days, reproductively mature zebrafish (Danio rerio) (F0) were exposed to MTA at environmental concentrations (33, 100, 333, and 666 ng/L) for 21 days. Egg production was decreased in F0 fish exposed to MTA, with a significant decrease at 666 ng/L. The exposure significantly decreased the circulating concentrations of estradiol (E2) and testosterone (T) in female fish or 11-keto testosterone (11-KT) in male fish. MTA exposure significantly downregulated the transcription of certain genes along the hypothalamic-pituitary-gonadal (HPG) axis. MTA did not affect early embryonic development or hatching success in the F1 generation. The present study showed that MTA is a potent endocrine disruptor in fish, and short-term exposure to MTA could significantly affect reproduction in fish and negatively impact the fish population. (C) 2014 Elsevier B.V. All rights reserved.; Synthetic progestins contaminate the aquatic ecosystem, and may cause adverse health effects on aquatic organisms. Megestrol acetate (MTA) is present in the aquatic environment, but its possible effects on fish reproduction are unknown. In the present study, we investigated the endocrine disruption and impact of MTA on fish reproduction. After a pre-exposure period of 14 days, reproductively mature zebrafish (Danio rerio) (F0) were exposed to MTA at environmental concentrations (33, 100, 333, and 666 ng/L) for 21 days. Egg production was decreased in F0 fish exposed to MTA, with a significant decrease at 666 ng/L. The exposure significantly decreased the circulating concentrations of estradiol (E2) and testosterone (T) in female fish or 11-keto testosterone (11-KT) in male fish. MTA exposure significantly downregulated the transcription of certain genes along the hypothalamic-pituitary-gonadal (HPG) axis. MTA did not affect early embryonic development or hatching success in the F1 generation. The present study showed that MTA is a potent endocrine disruptor in fish, and short-term exposure to MTA could significantly affect reproduction in fish and negatively impact the fish population. (C) 2014 Elsevier B.V. All rights reserved.
SubtypeArticle
KeywordProgestin Endocrine Disruption Reproduction Hypothalamic-pituitary-gonadal Axis
Department[Han, Jian; Wang, Qiangwei; Wang, Xianfeng; Guo, Yongyong; Zhou, Bingsheng] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China; [Han, Jian; Wang, Qiangwei; Wang, Xianfeng] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Li, Yonggang; Wen, Sheng] Hubei Prov Ctr Dis Control & Prevent, Wuhan 430079, Peoples R China; [Liu, Shan] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China; [Ying, Guangguo] Chinese Acad Sci, Guangzhou Inst Geochem, State Key Lab Organ Geochem, Guangzhou 510640, Guangdong, Peoples R China
DOI10.1016/j.aquatox.2014.02.020
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Funding OrganizationNational Natural Science Foundation of China [21277170]; State Key Laboratory of Freshwater Ecology and Biotechnology [2011FBZ13] ; National Natural Science Foundation of China [21277170]; State Key Laboratory of Freshwater Ecology and Biotechnology [2011FBZ13] ; National Natural Science Foundation of China [21277170]; State Key Laboratory of Freshwater Ecology and Biotechnology [2011FBZ13] ; National Natural Science Foundation of China [21277170]; State Key Laboratory of Freshwater Ecology and Biotechnology [2011FBZ13]
Indexed BySCI
Language英语
WOS Research AreaMarine & Freshwater Biology ; Toxicology
WOS SubjectMarine & Freshwater Biology ; Toxicology
WOS IDWOS:000336187900008
WOS KeywordMINNOW PIMEPHALES-PROMELAS ; WASTE-WATER ; GENE-EXPRESSION ; DANIO-RERIO ; OOCYTE MATURATION ; XENOPUS-LAEVIS ; FISH ; LEVONORGESTREL ; PITUITARY ; HORMONES
Funding OrganizationNational Natural Science Foundation of China [21277170]; State Key Laboratory of Freshwater Ecology and Biotechnology [2011FBZ13] ; National Natural Science Foundation of China [21277170]; State Key Laboratory of Freshwater Ecology and Biotechnology [2011FBZ13] ; National Natural Science Foundation of China [21277170]; State Key Laboratory of Freshwater Ecology and Biotechnology [2011FBZ13] ; National Natural Science Foundation of China [21277170]; State Key Laboratory of Freshwater Ecology and Biotechnology [2011FBZ13]
Citation statistics
Cited Times:35[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/20064
Collection水环境工程研究中心_期刊论文
Corresponding AuthorZhou, BS (reprint author), Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China.
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Hubei Prov Ctr Dis Control & Prevent, Wuhan 430079, Peoples R China
4.Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China
5.Chinese Acad Sci, Guangzhou Inst Geochem, State Key Lab Organ Geochem, Guangzhou 510640, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Han, Jian,Wang, Qiangwei,Wang, Xianfeng,et al. The synthetic progestin megestrol acetate adversely affects zebrafish reproduction[J]. AQUATIC TOXICOLOGY,2014,150:66-72.
APA Han, Jian.,Wang, Qiangwei.,Wang, Xianfeng.,Li, Yonggang.,Wen, Sheng.,...&Zhou, BS .(2014).The synthetic progestin megestrol acetate adversely affects zebrafish reproduction.AQUATIC TOXICOLOGY,150,66-72.
MLA Han, Jian,et al."The synthetic progestin megestrol acetate adversely affects zebrafish reproduction".AQUATIC TOXICOLOGY 150(2014):66-72.
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