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题名: Gig1, a novel antiviral effector involved in fish interferon response
作者: Sun, Fan1; Zhang, Yi-Bing1; Jiang, Jun1; Wang, Bing1; Chen, Chen1; Zhang, Jun1; Gui, Jian-Fang1
通讯作者: Zhang, YB (reprint author), Univ Chinese Acad Sci, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China.
关键词: Fish ; Gig1 ; Expression regulation ; RLR signaling pathway ; Antiviral effects ; IFN response ; Gene family
刊名: VIROLOGY
发表日期: 2014-01-05
DOI: 10.1016/j.virol.2013.10.029
卷: 448, 期:-, 页:322-332
收录类别: SCI
文章类型: Article
部门归属: [Sun, Fan; Zhang, Yi-Bing; Jiang, Jun; Wang, Bing; Chen, Chen; Zhang, Jun; Gui, Jian-Fang] Univ Chinese Acad Sci, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
资助者: Strategic Priority Research Program of the Chinese Academy of Sciences [XDA08010207]; National Natural Science Foundation of China [31272690, 31172435]; 973 National Basic Research Program of China [2010CB126303]
类目[WOS]: Virology
研究领域[WOS]: Virology
摘要: Vertebrate interferon (IFN) response defenses against viral infection through the induction of hundreds of IFN-stimulated genes (ISGs). Most ISGs are conserved across vertebrates; however, little is known about the species-specific ISGs. In this study, we reported that grass carp reovirus (GCRV)-induced gene 1 (Gig1), previously screened as a virus-induced gene from UV-inactivated GCRV-infected crucian carp (Carassius auratus) blastulae embryonic (CAB) cells, was a typical fish ISG, which was significantly induced by intracellular poly(I:C) through retinoic acid-inducible gene I (RIG-I)-like receptors-triggered IFN signaling pathway. Transient or stable overexpression of Gig1 prevented GCRV replication efficiently in cultured fish cells. Strikingly, Gig1 homologs were found exclusively in fish species forming a novel gene family. These results illustrate that there exists a Gig1 gene family unique to fish species and the founding gene mediates a novel fish IFN antiviral pathway. (C) 2013 Elsevier Inc. All rights reserved.
英文摘要: Vertebrate interferon (IFN) response defenses against viral infection through the induction of hundreds of IFN-stimulated genes (ISGs). Most ISGs are conserved across vertebrates; however, little is known about the species-specific ISGs. In this study, we reported that grass carp reovirus (GCRV)-induced gene 1 (Gig1), previously screened as a virus-induced gene from UV-inactivated GCRV-infected crucian carp (Carassius auratus) blastulae embryonic (CAB) cells, was a typical fish ISG, which was significantly induced by intracellular poly(I:C) through retinoic acid-inducible gene I (RIG-I)-like receptors-triggered IFN signaling pathway. Transient or stable overexpression of Gig1 prevented GCRV replication efficiently in cultured fish cells. Strikingly, Gig1 homologs were found exclusively in fish species forming a novel gene family. These results illustrate that there exists a Gig1 gene family unique to fish species and the founding gene mediates a novel fish IFN antiviral pathway. (C) 2013 Elsevier Inc. All rights reserved.
关键词[WOS]: DEPENDENT PROTEIN-KINASE ; INNATE IMMUNE-RESPONSE ; UV-INACTIVATED VIRUS ; DNA BINDING DOMAINS ; SALMON SALMO-SALAR ; ATLANTIC SALMON ; FUNCTIONAL-CHARACTERIZATION ; CAB CELLS ; CARASSIUS-AURATUS ; STIMULATED GENES
语种: 英语
WOS记录号: WOS:000328710800034
ISSN号: 0042-6822
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/20054
Appears in Collections:鱼类生物学及渔业生物技术研究中心_期刊论文

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作者单位: 1.Univ Chinese Acad Sci, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
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