| Gig1, a novel antiviral effector involved in fish interferon response | |
| Sun, Fan; Zhang, Yi-Bing; Jiang, Jun; Wang, Bing; Chen, Chen; Zhang, Jun; Gui, Jian-Fang; Zhang, YB (reprint author), Univ Chinese Acad Sci, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China. | |
| 2014-01-05 | |
| Source Publication | VIROLOGY
 |
| ISSN | 0042-6822 |
| Volume | 448Issue:-Pages:322-332 |
| Abstract | Vertebrate interferon (IFN) response defenses against viral infection through the induction of hundreds of IFN-stimulated genes (ISGs). Most ISGs are conserved across vertebrates; however, little is known about the species-specific ISGs. In this study, we reported that grass carp reovirus (GCRV)-induced gene 1 (Gig1), previously screened as a virus-induced gene from UV-inactivated GCRV-infected crucian carp (Carassius auratus) blastulae embryonic (CAB) cells, was a typical fish ISG, which was significantly induced by intracellular poly(I:C) through retinoic acid-inducible gene I (RIG-I)-like receptors-triggered IFN signaling pathway. Transient or stable overexpression of Gig1 prevented GCRV replication efficiently in cultured fish cells. Strikingly, Gig1 homologs were found exclusively in fish species forming a novel gene family. These results illustrate that there exists a Gig1 gene family unique to fish species and the founding gene mediates a novel fish IFN antiviral pathway. (C) 2013 Elsevier Inc. All rights reserved.; Vertebrate interferon (IFN) response defenses against viral infection through the induction of hundreds of IFN-stimulated genes (ISGs). Most ISGs are conserved across vertebrates; however, little is known about the species-specific ISGs. In this study, we reported that grass carp reovirus (GCRV)-induced gene 1 (Gig1), previously screened as a virus-induced gene from UV-inactivated GCRV-infected crucian carp (Carassius auratus) blastulae embryonic (CAB) cells, was a typical fish ISG, which was significantly induced by intracellular poly(I:C) through retinoic acid-inducible gene I (RIG-I)-like receptors-triggered IFN signaling pathway. Transient or stable overexpression of Gig1 prevented GCRV replication efficiently in cultured fish cells. Strikingly, Gig1 homologs were found exclusively in fish species forming a novel gene family. These results illustrate that there exists a Gig1 gene family unique to fish species and the founding gene mediates a novel fish IFN antiviral pathway. (C) 2013 Elsevier Inc. All rights reserved. |
| Subtype | Article |
| Keyword | Fish Gig1 Expression Regulation Rlr Signaling Pathway Antiviral Effects Ifn Response Gene Family |
| Department | [Sun, Fan; Zhang, Yi-Bing; Jiang, Jun; Wang, Bing; Chen, Chen; Zhang, Jun; Gui, Jian-Fang] Univ Chinese Acad Sci, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China |
| DOI | 10.1016/j.virol.2013.10.029 |
| WOS Headings | Science & Technology ; Life Sciences & Biomedicine |
| Funding Organization | Strategic Priority Research Program of the Chinese Academy of Sciences [XDA08010207]; National Natural Science Foundation of China [31272690, 31172435]; 973 National Basic Research Program of China [2010CB126303] ; Strategic Priority Research Program of the Chinese Academy of Sciences [XDA08010207]; National Natural Science Foundation of China [31272690, 31172435]; 973 National Basic Research Program of China [2010CB126303] ; Strategic Priority Research Program of the Chinese Academy of Sciences [XDA08010207]; National Natural Science Foundation of China [31272690, 31172435]; 973 National Basic Research Program of China [2010CB126303] ; Strategic Priority Research Program of the Chinese Academy of Sciences [XDA08010207]; National Natural Science Foundation of China [31272690, 31172435]; 973 National Basic Research Program of China [2010CB126303] |
| Indexed By | SCI |
| Language | 英语 |
| WOS Research Area | Virology |
| WOS Subject | Virology |
| WOS ID | WOS:000328710800034 |
| WOS Keyword | DEPENDENT PROTEIN-KINASE ; INNATE IMMUNE-RESPONSE ; UV-INACTIVATED VIRUS ; DNA BINDING DOMAINS ; SALMON SALMO-SALAR ; ATLANTIC SALMON ; FUNCTIONAL-CHARACTERIZATION ; CAB CELLS ; CARASSIUS-AURATUS ; STIMULATED GENES |
| Funding Organization | Strategic Priority Research Program of the Chinese Academy of Sciences [XDA08010207]; National Natural Science Foundation of China [31272690, 31172435]; 973 National Basic Research Program of China [2010CB126303] ; Strategic Priority Research Program of the Chinese Academy of Sciences [XDA08010207]; National Natural Science Foundation of China [31272690, 31172435]; 973 National Basic Research Program of China [2010CB126303] ; Strategic Priority Research Program of the Chinese Academy of Sciences [XDA08010207]; National Natural Science Foundation of China [31272690, 31172435]; 973 National Basic Research Program of China [2010CB126303] ; Strategic Priority Research Program of the Chinese Academy of Sciences [XDA08010207]; National Natural Science Foundation of China [31272690, 31172435]; 973 National Basic Research Program of China [2010CB126303] |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ihb.ac.cn/handle/342005/20054 |
| Collection | 鱼类生物学及渔业生物技术研究中心_期刊论文 |
| Corresponding Author | Zhang, YB (reprint author), Univ Chinese Acad Sci, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China. |
| Affiliation | Univ Chinese Acad Sci, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China |
| Recommended Citation GB/T 7714 | Sun, Fan,Zhang, Yi-Bing,Jiang, Jun,et al. Gig1, a novel antiviral effector involved in fish interferon response[J]. VIROLOGY,2014,448(-):322-332. |
| APA | Sun, Fan.,Zhang, Yi-Bing.,Jiang, Jun.,Wang, Bing.,Chen, Chen.,...&Zhang, YB .(2014).Gig1, a novel antiviral effector involved in fish interferon response.VIROLOGY,448(-),322-332. |
| MLA | Sun, Fan,et al."Gig1, a novel antiviral effector involved in fish interferon response".VIROLOGY 448.-(2014):322-332. |
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