IHB OpenIR  > 鱼类生物学及渔业生物技术研究中心  > 期刊论文
Gig1, a novel antiviral effector involved in fish interferon response
Sun, Fan; Zhang, Yi-Bing; Jiang, Jun; Wang, Bing; Chen, Chen; Zhang, Jun; Gui, Jian-Fang; Zhang, YB (reprint author), Univ Chinese Acad Sci, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China.
2014-01-05
Source PublicationVIROLOGY
ISSN0042-6822
Volume448Issue:-Pages:322-332
AbstractVertebrate interferon (IFN) response defenses against viral infection through the induction of hundreds of IFN-stimulated genes (ISGs). Most ISGs are conserved across vertebrates; however, little is known about the species-specific ISGs. In this study, we reported that grass carp reovirus (GCRV)-induced gene 1 (Gig1), previously screened as a virus-induced gene from UV-inactivated GCRV-infected crucian carp (Carassius auratus) blastulae embryonic (CAB) cells, was a typical fish ISG, which was significantly induced by intracellular poly(I:C) through retinoic acid-inducible gene I (RIG-I)-like receptors-triggered IFN signaling pathway. Transient or stable overexpression of Gig1 prevented GCRV replication efficiently in cultured fish cells. Strikingly, Gig1 homologs were found exclusively in fish species forming a novel gene family. These results illustrate that there exists a Gig1 gene family unique to fish species and the founding gene mediates a novel fish IFN antiviral pathway. (C) 2013 Elsevier Inc. All rights reserved.; Vertebrate interferon (IFN) response defenses against viral infection through the induction of hundreds of IFN-stimulated genes (ISGs). Most ISGs are conserved across vertebrates; however, little is known about the species-specific ISGs. In this study, we reported that grass carp reovirus (GCRV)-induced gene 1 (Gig1), previously screened as a virus-induced gene from UV-inactivated GCRV-infected crucian carp (Carassius auratus) blastulae embryonic (CAB) cells, was a typical fish ISG, which was significantly induced by intracellular poly(I:C) through retinoic acid-inducible gene I (RIG-I)-like receptors-triggered IFN signaling pathway. Transient or stable overexpression of Gig1 prevented GCRV replication efficiently in cultured fish cells. Strikingly, Gig1 homologs were found exclusively in fish species forming a novel gene family. These results illustrate that there exists a Gig1 gene family unique to fish species and the founding gene mediates a novel fish IFN antiviral pathway. (C) 2013 Elsevier Inc. All rights reserved.
SubtypeArticle
KeywordFish Gig1 Expression Regulation Rlr Signaling Pathway Antiviral Effects Ifn Response Gene Family
Department[Sun, Fan; Zhang, Yi-Bing; Jiang, Jun; Wang, Bing; Chen, Chen; Zhang, Jun; Gui, Jian-Fang] Univ Chinese Acad Sci, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
DOI10.1016/j.virol.2013.10.029
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Funding OrganizationStrategic Priority Research Program of the Chinese Academy of Sciences [XDA08010207]; National Natural Science Foundation of China [31272690, 31172435]; 973 National Basic Research Program of China [2010CB126303] ; Strategic Priority Research Program of the Chinese Academy of Sciences [XDA08010207]; National Natural Science Foundation of China [31272690, 31172435]; 973 National Basic Research Program of China [2010CB126303] ; Strategic Priority Research Program of the Chinese Academy of Sciences [XDA08010207]; National Natural Science Foundation of China [31272690, 31172435]; 973 National Basic Research Program of China [2010CB126303] ; Strategic Priority Research Program of the Chinese Academy of Sciences [XDA08010207]; National Natural Science Foundation of China [31272690, 31172435]; 973 National Basic Research Program of China [2010CB126303]
Indexed BySCI
Language英语
WOS Research AreaVirology
WOS SubjectVirology
WOS IDWOS:000328710800034
WOS KeywordDEPENDENT PROTEIN-KINASE ; INNATE IMMUNE-RESPONSE ; UV-INACTIVATED VIRUS ; DNA BINDING DOMAINS ; SALMON SALMO-SALAR ; ATLANTIC SALMON ; FUNCTIONAL-CHARACTERIZATION ; CAB CELLS ; CARASSIUS-AURATUS ; STIMULATED GENES
Funding OrganizationStrategic Priority Research Program of the Chinese Academy of Sciences [XDA08010207]; National Natural Science Foundation of China [31272690, 31172435]; 973 National Basic Research Program of China [2010CB126303] ; Strategic Priority Research Program of the Chinese Academy of Sciences [XDA08010207]; National Natural Science Foundation of China [31272690, 31172435]; 973 National Basic Research Program of China [2010CB126303] ; Strategic Priority Research Program of the Chinese Academy of Sciences [XDA08010207]; National Natural Science Foundation of China [31272690, 31172435]; 973 National Basic Research Program of China [2010CB126303] ; Strategic Priority Research Program of the Chinese Academy of Sciences [XDA08010207]; National Natural Science Foundation of China [31272690, 31172435]; 973 National Basic Research Program of China [2010CB126303]
Citation statistics
Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/20054
Collection鱼类生物学及渔业生物技术研究中心_期刊论文
Corresponding AuthorZhang, YB (reprint author), Univ Chinese Acad Sci, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China.
AffiliationUniv Chinese Acad Sci, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
Recommended Citation
GB/T 7714
Sun, Fan,Zhang, Yi-Bing,Jiang, Jun,et al. Gig1, a novel antiviral effector involved in fish interferon response[J]. VIROLOGY,2014,448(-):322-332.
APA Sun, Fan.,Zhang, Yi-Bing.,Jiang, Jun.,Wang, Bing.,Chen, Chen.,...&Zhang, YB .(2014).Gig1, a novel antiviral effector involved in fish interferon response.VIROLOGY,448(-),322-332.
MLA Sun, Fan,et al."Gig1, a novel antiviral effector involved in fish interferon response".VIROLOGY 448.-(2014):322-332.
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