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题名: Identification and expression profiles of prdm1 in medaka Oryzias latipes
作者: Zhao, Haobin1, 2; Zhang, Xiaosha1; Cheng, Nana1; Duan, Jundan1; Wang, Jialin1; Nagahama, Yoshitaka2, 3; Zhong, Xueping1; Zhou, Qingchun1; Wang, Yaping4
通讯作者: Zhao, HB (reprint author), Cent China Normal Univ, Coll Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Peoples R China.
关键词: Medaka ; Zebrafish ; Prdm1a ; Prdm1b ; Embryogenesis ; Gene expression ; Immune response
刊名: MOLECULAR BIOLOGY REPORTS
发表日期: 2014-02-01
DOI: 10.1007/s11033-013-2899-2
卷: 41, 期:2, 页:617-626
收录类别: SCI
文章类型: Article
部门归属: [Zhao, Haobin ; Zhang, Xiaosha ; Cheng, Nana ; Duan, Jundan ; Wang, Jialin ; Zhong, Xueping ; Zhou, Qingchun] Cent China Normal Univ, Coll Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Peoples R China ; [Zhao, Haobin ; Nagahama, Yoshitaka] Japan Soc Promot Sci, Tokyo 1028471, Japan ; [Nagahama, Yoshitaka] Ehime Univ, Inst Collaborat Relat, Matsuyama, Ehime 7908577, Japan ; [Wang, Yaping] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Fresh Water Ecol & Biotechnol, Wuhan 430074, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
资助者: National Natural Science Foundation of China [31272645, 30972254, 31071997]; Japan Society for the Promotion of Science
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
摘要: Mouse Prdm1, also known as Blimp1, plays important roles in maturation and survival of lymphoid cells, as well as in organogenesis of muscle, limb, sensor organs and primordial germ cells. The homologues of mouse prdm1 have been identified in a diverse of animals including zebrafish and fugu. Here, we report the identification and expression profiles of two homologues of prdm1, namely prdm1a and prdm1b in medaka, Oryzias latipes. The transcripts of prdm1a and prdm1b were detectable in all the tissues including immune organs such as gill, spleen, kidney, liver and intestine that we have checked on. The transcripts of prdm1a could be detected in the embryonic shield at mid-gastrula stage and later in the somite, eye, otic vesicle, branchial arches, fin, intestine and cloaca during embryogenesis using in situ hybridization. Moreover, the expression of prdm1a in the liver of both medaka and zebrafish could be up-regulated by the immune stimuli including lipopolysaccharide, polyI:C and the grass carp reovirus, similarly to the up-regulation of IL1B. These results indicate that Prdm1a may play important roles in embryogenesis and also in immune response in fish.
英文摘要: Mouse Prdm1, also known as Blimp1, plays important roles in maturation and survival of lymphoid cells, as well as in organogenesis of muscle, limb, sensor organs and primordial germ cells. The homologues of mouse prdm1 have been identified in a diverse of animals including zebrafish and fugu. Here, we report the identification and expression profiles of two homologues of prdm1, namely prdm1a and prdm1b in medaka, Oryzias latipes. The transcripts of prdm1a and prdm1b were detectable in all the tissues including immune organs such as gill, spleen, kidney, liver and intestine that we have checked on. The transcripts of prdm1a could be detected in the embryonic shield at mid-gastrula stage and later in the somite, eye, otic vesicle, branchial arches, fin, intestine and cloaca during embryogenesis using in situ hybridization. Moreover, the expression of prdm1a in the liver of both medaka and zebrafish could be up-regulated by the immune stimuli including lipopolysaccharide, polyI:C and the grass carp reovirus, similarly to the up-regulation of IL1B. These results indicate that Prdm1a may play important roles in embryogenesis and also in immune response in fish.
关键词[WOS]: INDUCED MATURATION PROTEIN-1 ; TRANSCRIPTIONAL REPRESSOR BLIMP1/PRDM1 ; SECRETING PLASMA-CELLS ; TUMOR-SUPPRESSOR GENE ; PRIMORDIAL GERM-CELLS ; B-CELL ; BLIMP-1 EXPRESSION ; NEURAL CREST ; DIFFERENTIATION ; LYMPHOCYTES
语种: 英语
WOS记录号: WOS:000330860900006
ISSN号: 0301-4851
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/20051
Appears in Collections:鱼类生物学及渔业生物技术研究中心_期刊论文

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作者单位: 1.Cent China Normal Univ, Coll Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Peoples R China
2.Japan Soc Promot Sci, Tokyo 1028471, Japan
3.Ehime Univ, Inst Collaborat Relat, Matsuyama, Ehime 7908577, Japan
4.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Fresh Water Ecol & Biotechnol, Wuhan 430074, Peoples R China

Recommended Citation:
Zhao, Haobin; Zhang, Xiaosha; Cheng, Nana; Duan, Jundan; Wang, Jialin; Nagahama, Yoshitaka; Zhong, Xueping; Zhou, Qingchun; Wang, Yaping.Identification and expression profiles of prdm1 in medaka Oryzias latipes,MOLECULAR BIOLOGY REPORTS,2014,41(2):617-626
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