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题名: Toxicogenomic Responses of Zebrafish Embryos/Larvae to Tris(1,3-dichloro-2-propyl) Phosphate (TDCPP) Reveal Possible Molecular Mechanisms of Developmental Toxicity
作者: Fu, Jie1, 2; Han, Jian3; Zhou, Bingsheng3; Gong, Zhiyuan4; Santos, Eduarda M.5; Huo, Xiaojing4; Zheng, Weiling4; Liu, Hongling1, 2; Yu, Hongxia1, 2; Liu, Chunsheng1, 2
通讯作者: Liu, CS (reprint author), Nanjing Univ, Sch Environm, Nanjing 210023, Jiangsu, Peoples R China.
刊名: ENVIRONMENTAL SCIENCE & TECHNOLOGY
发表日期: 2013-09-17
DOI: 10.1021/es401265q
卷: 47, 期:18, 页:10574-10582
收录类别: SCI
文章类型: Article
部门归属: [Fu, Jie; Liu, Hongling; Yu, Hongxia; Liu, Chunsheng] Nanjing Univ, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Jiangsu, Peoples R China; [Fu, Jie; Liu, Hongling; Yu, Hongxia; Liu, Chunsheng] Nanjing Univ, Sch Environm, Nanjing 210023, Jiangsu, Peoples R China; [Han, Jian; Zhou, Bingsheng] Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China; [Gong, Zhiyuan; Huo, Xiaojing; Zheng, Weiling] Natl Univ Singapore, Dept Biol Sci, Singapore 119077, Singapore; [Santos, Eduarda M.] Univ Exeter, Coll Life & Environm Sci, Exeter EX4 4PS, Devon, England
WOS标题词: Science & Technology ; Technology ; Life Sciences & Biomedicine
资助者: National Natural Science Foundation of China [21207063]; Environmental Protection Department of Jiangsu Province [2012044]; Fundamental Research Funds for the Central Universities [1127021126]
类目[WOS]: Engineering, Environmental ; Environmental Sciences
研究领域[WOS]: Engineering ; Environmental Sciences & Ecology
摘要: Tris(1,3-dichloro-2-propyl) phosphate (TDCPP) is frequently present in indoor dust and can be detected in human milk. In order to evaluate the effects of TDCPP on vertebrate development, zebrafish embryos/larvae were used as an animal model to examine developmental phenotypes and explore possible mechanisms of toxicity by employing microarrays and iTRAQ labeling quantitative proteomics. The results demonstrated that treatment with TDCPP (3 mu M) from 0.75 h postfertilization (hpf) inhibited cell rearrangement at 4 hpf, caused delay in epiboly at 5.7 and 8.5 hpf, and led to abnormal development (e.g., short tail, reduced body size) and lethality between 14 and 45 hpf, which might be related with altered expression of genes regulating embryogenesis. Furthermore, trunk curvature was observed as the main phenotype in 96 hpf zebrafish larvae exposed to 1 or 3 mu M TDCPP, possibly by changing somite formation and expression of proteins related to fast muscle and cartilage development. Collectively, our results suggest that exposure to TDCPP causes developmental toxicity in vertebrates and warrant the need for studies to evaluate the potential health risks of TDCPP to developing human embryos/infants/children, due to its frequent presence in indoor dust and potential for human exposure.
英文摘要: Tris(1,3-dichloro-2-propyl) phosphate (TDCPP) is frequently present in indoor dust and can be detected in human milk. In order to evaluate the effects of TDCPP on vertebrate development, zebrafish embryos/larvae were used as an animal model to examine developmental phenotypes and explore possible mechanisms of toxicity by employing microarrays and iTRAQ labeling quantitative proteomics. The results demonstrated that treatment with TDCPP (3 mu M) from 0.75 h postfertilization (hpf) inhibited cell rearrangement at 4 hpf, caused delay in epiboly at 5.7 and 8.5 hpf, and led to abnormal development (e.g., short tail, reduced body size) and lethality between 14 and 45 hpf, which might be related with altered expression of genes regulating embryogenesis. Furthermore, trunk curvature was observed as the main phenotype in 96 hpf zebrafish larvae exposed to 1 or 3 mu M TDCPP, possibly by changing somite formation and expression of proteins related to fast muscle and cartilage development. Collectively, our results suggest that exposure to TDCPP causes developmental toxicity in vertebrates and warrant the need for studies to evaluate the potential health risks of TDCPP to developing human embryos/infants/children, due to its frequent presence in indoor dust and potential for human exposure.
关键词[WOS]: ORGANOPHOSPHATE FLAME RETARDANTS ; IMPRINTED GENE NETWORK ; PROTEIN EXPRESSION ; EMBRYONIC GROWTH ; DUST ; EXPOSURE ; HYPOXIA ; SAMPLES ; FAMILY ; RNA
语种: 英语
WOS记录号: WOS:000330096000063
ISSN号: 0013-936X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/19978
Appears in Collections:水环境工程研究中心_期刊论文

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作者单位: 1.Nanjing Univ, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Jiangsu, Peoples R China
2.Nanjing Univ, Sch Environm, Nanjing 210023, Jiangsu, Peoples R China
3.Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China
4.Natl Univ Singapore, Dept Biol Sci, Singapore 119077, Singapore
5.Univ Exeter, Coll Life & Environm Sci, Exeter EX4 4PS, Devon, England
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