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题名: Apolipoprotein C1 regulates epiboly during gastrulation in zebrafish
作者: Wang Yang1; Zhou Li1; Li Zhi1; Li WenHua1; Gui JianFang1
通讯作者: Gui, JF (reprint author), Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China.
关键词: epiboly ; apolipoprotein C1 ; E-cadherin ; radial intercalation
刊名: SCIENCE CHINA-LIFE SCIENCES
发表日期: 2013-11-01
DOI: 10.1007/s11427-013-4563-4
卷: 56, 期:11, 页:975-984
收录类别: SCI
文章类型: Article
部门归属: [Wang Yang ; Zhou Li ; Li Zhi ; Li WenHua ; Gui JianFang] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
资助者: National Basic Research Program of China [2010CB126300]; National High Technology Research and Development Program of China [2012AA092201-3]; Ministry of Agriculture of China [200903045]; National Natural Science Foundation of China [30971414]
类目[WOS]: Biology
研究领域[WOS]: Life Sciences & Biomedicine - Other Topics
摘要: Apolipoprotein C1 (Apoc1) is associated with lipoprotein metabolism, but its physiological role during embryogenesis is largely unknown. We reveal a new function of Apoc1b, a transcript isoform of Apoc1, in epiboly during zebrafish gastrulation. Apoc1b is expressed in yolk syncytial layers and in deep cells of the ventral and lateral region of the embryos. It displays a radial gradient with high levels in the interior layer and low levels in the superficial layer. Knockdown of Apoc1b by injecting antisense morpholino (MO) caused the epiboly arrest in deep cells. Moreover, we show that the radial intercalation and the radial gradient distribution of E-cadherin are disrupted both in Apoc1b knockdown and overexpressed embryos. Therefore, Apoc1b controls epiboly via E-cadherin-mediated radial intercalation in a gradient-dependent manner.
英文摘要: Apolipoprotein C1 (Apoc1) is associated with lipoprotein metabolism, but its physiological role during embryogenesis is largely unknown. We reveal a new function of Apoc1b, a transcript isoform of Apoc1, in epiboly during zebrafish gastrulation. Apoc1b is expressed in yolk syncytial layers and in deep cells of the ventral and lateral region of the embryos. It displays a radial gradient with high levels in the interior layer and low levels in the superficial layer. Knockdown of Apoc1b by injecting antisense morpholino (MO) caused the epiboly arrest in deep cells. Moreover, we show that the radial intercalation and the radial gradient distribution of E-cadherin are disrupted both in Apoc1b knockdown and overexpressed embryos. Therefore, Apoc1b controls epiboly via E-cadherin-mediated radial intercalation in a gradient-dependent manner.
关键词[WOS]: ORANGE-SPOTTED GROUPER ; CELL MOVEMENTS ; VERTEBRATE GASTRULATION ; MOLECULAR-CLONING ; E-CADHERIN ; EXPRESSION ; YOLK ; MICROFILAMENTS ; ORGANIZATION ; CYTOSKELETON
语种: 英语
WOS记录号: WOS:000326813300001
ISSN号: 1674-7305
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/19772
Appears in Collections:鱼类生物学及渔业生物技术研究中心_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China

Recommended Citation:
Wang Yang; Zhou Li; Li Zhi; Li WenHua; Gui JianFang.Apolipoprotein C1 regulates epiboly during gastrulation in zebrafish,SCIENCE CHINA-LIFE SCIENCES,2013,56(11):975-984
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