IHB OpenIR  > 鱼类生物学及渔业生物技术研究中心  > 期刊论文
Apolipoprotein C1 regulates epiboly during gastrulation in zebrafish
Wang Yang; Zhou Li; Li Zhi; Li WenHua; Gui JianFang; Gui, JF (reprint author), Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China.
2013-11-01
Source PublicationSCIENCE CHINA-LIFE SCIENCES
ISSN1674-7305
Volume56Issue:11Pages:975-984
AbstractApolipoprotein C1 (Apoc1) is associated with lipoprotein metabolism, but its physiological role during embryogenesis is largely unknown. We reveal a new function of Apoc1b, a transcript isoform of Apoc1, in epiboly during zebrafish gastrulation. Apoc1b is expressed in yolk syncytial layers and in deep cells of the ventral and lateral region of the embryos. It displays a radial gradient with high levels in the interior layer and low levels in the superficial layer. Knockdown of Apoc1b by injecting antisense morpholino (MO) caused the epiboly arrest in deep cells. Moreover, we show that the radial intercalation and the radial gradient distribution of E-cadherin are disrupted both in Apoc1b knockdown and overexpressed embryos. Therefore, Apoc1b controls epiboly via E-cadherin-mediated radial intercalation in a gradient-dependent manner.; Apolipoprotein C1 (Apoc1) is associated with lipoprotein metabolism, but its physiological role during embryogenesis is largely unknown. We reveal a new function of Apoc1b, a transcript isoform of Apoc1, in epiboly during zebrafish gastrulation. Apoc1b is expressed in yolk syncytial layers and in deep cells of the ventral and lateral region of the embryos. It displays a radial gradient with high levels in the interior layer and low levels in the superficial layer. Knockdown of Apoc1b by injecting antisense morpholino (MO) caused the epiboly arrest in deep cells. Moreover, we show that the radial intercalation and the radial gradient distribution of E-cadherin are disrupted both in Apoc1b knockdown and overexpressed embryos. Therefore, Apoc1b controls epiboly via E-cadherin-mediated radial intercalation in a gradient-dependent manner.
SubtypeArticle
KeywordEpiboly Apolipoprotein C1 E-cadherin Radial Intercalation
Department[Wang Yang ; Zhou Li ; Li Zhi ; Li WenHua ; Gui JianFang] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
DOI10.1007/s11427-013-4563-4
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Funding OrganizationNational Basic Research Program of China [2010CB126300]; National High Technology Research and Development Program of China [2012AA092201-3]; Ministry of Agriculture of China [200903045]; National Natural Science Foundation of China [30971414] ; National Basic Research Program of China [2010CB126300]; National High Technology Research and Development Program of China [2012AA092201-3]; Ministry of Agriculture of China [200903045]; National Natural Science Foundation of China [30971414] ; National Basic Research Program of China [2010CB126300]; National High Technology Research and Development Program of China [2012AA092201-3]; Ministry of Agriculture of China [200903045]; National Natural Science Foundation of China [30971414] ; National Basic Research Program of China [2010CB126300]; National High Technology Research and Development Program of China [2012AA092201-3]; Ministry of Agriculture of China [200903045]; National Natural Science Foundation of China [30971414]
Indexed BySCI
Language英语
WOS Research AreaLife Sciences & Biomedicine - Other Topics
WOS SubjectBiology
WOS IDWOS:000326813300001
WOS KeywordORANGE-SPOTTED GROUPER ; CELL MOVEMENTS ; VERTEBRATE GASTRULATION ; MOLECULAR-CLONING ; E-CADHERIN ; EXPRESSION ; YOLK ; MICROFILAMENTS ; ORGANIZATION ; CYTOSKELETON
Funding OrganizationNational Basic Research Program of China [2010CB126300]; National High Technology Research and Development Program of China [2012AA092201-3]; Ministry of Agriculture of China [200903045]; National Natural Science Foundation of China [30971414] ; National Basic Research Program of China [2010CB126300]; National High Technology Research and Development Program of China [2012AA092201-3]; Ministry of Agriculture of China [200903045]; National Natural Science Foundation of China [30971414] ; National Basic Research Program of China [2010CB126300]; National High Technology Research and Development Program of China [2012AA092201-3]; Ministry of Agriculture of China [200903045]; National Natural Science Foundation of China [30971414] ; National Basic Research Program of China [2010CB126300]; National High Technology Research and Development Program of China [2012AA092201-3]; Ministry of Agriculture of China [200903045]; National Natural Science Foundation of China [30971414]
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Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/19772
Collection鱼类生物学及渔业生物技术研究中心_期刊论文
Corresponding AuthorGui, JF (reprint author), Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China.
AffiliationChinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
Recommended Citation
GB/T 7714
Wang Yang,Zhou Li,Li Zhi,et al. Apolipoprotein C1 regulates epiboly during gastrulation in zebrafish[J]. SCIENCE CHINA-LIFE SCIENCES,2013,56(11):975-984.
APA Wang Yang,Zhou Li,Li Zhi,Li WenHua,Gui JianFang,&Gui, JF .(2013).Apolipoprotein C1 regulates epiboly during gastrulation in zebrafish.SCIENCE CHINA-LIFE SCIENCES,56(11),975-984.
MLA Wang Yang,et al."Apolipoprotein C1 regulates epiboly during gastrulation in zebrafish".SCIENCE CHINA-LIFE SCIENCES 56.11(2013):975-984.
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