IHB OpenIR  > 水环境工程研究中心  > 期刊论文
Pharmaceuticals in Tap Water: Human Health Risk Assessment and Proposed Monitoring Framework in China
Leung, Ho Wing1,2; Jin, Ling1,2,3; Wei, Si4; Tsui, Mirabelle Mei Po1,2; Zhou, Bingsheng5; Jiao, Liping6,7; Cheung, Pak Chuen1,2; Chun, Yiu Kan1,2; Murphy, Margaret Burkhardt1,2; Lam, Paul Kwan Sing1,2; Lam, PKS (reprint author), City Univ Hong Kong, 6213 CYC Bldg,83 Tat Chee Ave, Kowloon, Hong Kong, Peoples R China.
2013-07-01
Source PublicationENVIRONMENTAL HEALTH PERSPECTIVES
ISSN0091-6765
Volume121Issue:7Pages:839-846
AbstractBACKGROUND: Pharmaceuticals are known to contaminate tap water worldwide, but the relevant human health risks have not been assessed in China. OBJECTIVES: We monitored 32 pharmaceuticals in Chinese tap water and evaluated the life-long human health risks of exposure in order to provide information for future prioritization and risk management. METHODS: We analyzed samples (n = 113) from 13 cities and compared detected concentrations with existing or newly-derived safety levels for assessing risk quotients (RQs) at different life stages, excluding the prenatal stage. RESULTS: We detected 17 pharmaceuticals in 89% of samples, with most detectable concentrations (92%) at < 50 ng/L. Caffeine (median-maximum, nanograms per liter: 24.4-564), metronidazole (1.8-19.3), salicylic acid (16.6-41.2), clofibric acid (1.2-3.3), carbamazepine (1.3-6.7), and dimetridazole (6.9-14.7) were found in >= 20% of samples. Cities within the Yangtze River region and Guangzhou were regarded as contamination hot spots because of elevated levels and frequent positive detections. Of the 17 pharmaceuticals detected, 13 showed very low risk levels, but 4 (i.e., dimetridazole, thiamphenicol, sulfamethazine, and clarithromycin) were found to have at least one life-stage RQ >= 0.01, especially for the infant and child life stages, and should be considered of high priority for management. We propose an indicator-based monitoring framework for providing information for source identification, water treatment effectiveness, and water safety management in China. CONCLUSION: Chinese tap water is an additional route of human exposure to pharmaceuticals, particularly for dimetridazole, although the risk to human health is low based on current toxicity data. Pharmaceutical detection and application of the proposed monitoring framework can be used for water source protection and risk management in China and elsewhere.; BACKGROUND: Pharmaceuticals are known to contaminate tap water worldwide, but the relevant human health risks have not been assessed in China.
SubtypeArticle
KeywordChina Indicator Life Stage Pharmaceuticals Risk Assessment Tap Water
Department[Leung, Ho Wing; Jin, Ling; Tsui, Mirabelle Mei Po; Cheung, Pak Chuen; Chun, Yiu Kan; Murphy, Margaret Burkhardt; Lam, Paul Kwan Sing] City Univ Hong Kong, State Key Lab Marine Pollut, Hong Kong, Hong Kong, Peoples R China; [Leung, Ho Wing; Jin, Ling; Tsui, Mirabelle Mei Po; Cheung, Pak Chuen; Chun, Yiu Kan; Murphy, Margaret Burkhardt; Lam, Paul Kwan Sing] City Univ Hong Kong, Dept Biol & Chem, Hong Kong, Hong Kong, Peoples R China; [Jin, Ling] Univ Queensland, Natl Res Ctr Environm Toxicol, Brisbane, Qld, Australia; [Wei, Si] Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210008, Jiangsu, Peoples R China; [Zhou, Bingsheng] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Peoples R China; [Jiao, Liping] State Ocean Adm, Inst Oceanog 3, Xiamen, Peoples R China; [Jiao, Liping] State Ocean Adm, Key Lab Global Change & Marine Atmospher Chem, Xiamen, Peoples R China
DOI10.1289/ehp.1206244
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Funding OrganizationNational Natural Science Foundation of China-Research Grants Committee Joint Research Scheme [N_CityU127/12]; NSFC [21007022, 20890113]; Specialized Research Fund for the Doctoral Program of Higher Education [20100091120013] ; National Natural Science Foundation of China-Research Grants Committee Joint Research Scheme [N_CityU127/12]; NSFC [21007022, 20890113]; Specialized Research Fund for the Doctoral Program of Higher Education [20100091120013] ; National Natural Science Foundation of China-Research Grants Committee Joint Research Scheme [N_CityU127/12]; NSFC [21007022, 20890113]; Specialized Research Fund for the Doctoral Program of Higher Education [20100091120013] ; National Natural Science Foundation of China-Research Grants Committee Joint Research Scheme [N_CityU127/12]; NSFC [21007022, 20890113]; Specialized Research Fund for the Doctoral Program of Higher Education [20100091120013]
Indexed BySCI
Language英语
WOS Research AreaEnvironmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology
WOS SubjectEnvironmental Sciences ; Public, Environmental & Occupational Health ; Toxicology
WOS IDWOS:000323711000024
WOS KeywordPERSONAL CARE PRODUCTS ; DRINKING-WATER ; WASTE-WATER ; TREATMENT-PLANT ; SURFACE WATERS ; REMOVAL ; ANTIBIOTICS ; ENVIRONMENT ; CONTAMINATION ; INDICATORS
Funding OrganizationNational Natural Science Foundation of China-Research Grants Committee Joint Research Scheme [N_CityU127/12]; NSFC [21007022, 20890113]; Specialized Research Fund for the Doctoral Program of Higher Education [20100091120013] ; National Natural Science Foundation of China-Research Grants Committee Joint Research Scheme [N_CityU127/12]; NSFC [21007022, 20890113]; Specialized Research Fund for the Doctoral Program of Higher Education [20100091120013] ; National Natural Science Foundation of China-Research Grants Committee Joint Research Scheme [N_CityU127/12]; NSFC [21007022, 20890113]; Specialized Research Fund for the Doctoral Program of Higher Education [20100091120013] ; National Natural Science Foundation of China-Research Grants Committee Joint Research Scheme [N_CityU127/12]; NSFC [21007022, 20890113]; Specialized Research Fund for the Doctoral Program of Higher Education [20100091120013]
Citation statistics
Cited Times:81[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/19596
Collection水环境工程研究中心_期刊论文
Corresponding AuthorLam, PKS (reprint author), City Univ Hong Kong, 6213 CYC Bldg,83 Tat Chee Ave, Kowloon, Hong Kong, Peoples R China.
Affiliation1.City Univ Hong Kong, State Key Lab Marine Pollut, Hong Kong, Hong Kong, Peoples R China
2.City Univ Hong Kong, Dept Biol & Chem, Hong Kong, Hong Kong, Peoples R China
3.Univ Queensland, Natl Res Ctr Environm Toxicol, Brisbane, Qld, Australia
4.Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210008, Jiangsu, Peoples R China
5.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Peoples R China
6.State Ocean Adm, Inst Oceanog 3, Xiamen, Peoples R China
7.State Ocean Adm, Key Lab Global Change & Marine Atmospher Chem, Xiamen, Peoples R China
Recommended Citation
GB/T 7714
Leung, Ho Wing,Jin, Ling,Wei, Si,et al. Pharmaceuticals in Tap Water: Human Health Risk Assessment and Proposed Monitoring Framework in China[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2013,121(7):839-846.
APA Leung, Ho Wing.,Jin, Ling.,Wei, Si.,Tsui, Mirabelle Mei Po.,Zhou, Bingsheng.,...&Lam, PKS .(2013).Pharmaceuticals in Tap Water: Human Health Risk Assessment and Proposed Monitoring Framework in China.ENVIRONMENTAL HEALTH PERSPECTIVES,121(7),839-846.
MLA Leung, Ho Wing,et al."Pharmaceuticals in Tap Water: Human Health Risk Assessment and Proposed Monitoring Framework in China".ENVIRONMENTAL HEALTH PERSPECTIVES 121.7(2013):839-846.
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