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题名: Endocrine disruption by di-(2-ethylhexyl)-phthalate in Chinese rare minnow (Gobiocypris rarus)
作者: Wang, Xiaofang1, 2; Yang, Yuanjin3; Zhang, Liping1; Ma, Yanbo1; Han, Jian1; Yang, Lihua1; Zhou, Bingsheng1
通讯作者: Zhou, BS (reprint author), Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Peoples R China.
关键词: Di-(2-ethylhexyl)-phthalate (DEHP) ; Hypothalamic-pituitary-gonadal (HPG) axis ; Sex hormones ; Endocrine disruption ; Chinese rare minnow
刊名: ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
发表日期: 2013-08-01
DOI: 10.1002/etc.2261
卷: 32, 期:8, 页:1846-1854
收录类别: SCI
文章类型: Article
部门归属: [Wang, Xiaofang ; Zhang, Liping ; Ma, Yanbo ; Han, Jian ; Yang, Lihua ; Zhou, Bingsheng] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Peoples R China ; [Wang, Xiaofang] Univ Chinese Acad Sci, Beijing, Peoples R China ; [Yang, Yuanjin] China Three Gorges Corp, Inst Chinese Sturgeon Res, Yichang, Hubei, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
资助者: Science and Technology Research Project of China Three Gorges Corporation [07011034]
类目[WOS]: Environmental Sciences ; Toxicology
研究领域[WOS]: Environmental Sciences & Ecology ; Toxicology
摘要: Great concern has been raised over the potential impact of environmental contaminants on fish populations that inhabit the Three Gorge Reservoir. The present study investigated the endocrine-disrupting effects of di-(2-ethylhexyl)-phthalate (DEHP) on the Chinese rare minnow (Gobiocypris rarus), an endemic fish distributed in upstream waters in the Yangtze River. Adult rare minnow were exposed to environmentally relevant concentrations of DEHP (0 mu g/L, 3.6 mu g/L, 12.8 mu g/L, 39.4 mu g/L, and 117.6 mu g/L) for a 21-d period. Then, concentrations of sex hormones in the plasma and relative transcription of various associated genes were measured in the hypothalamic-pituitary-gonadal (HPG) axis and liver of the fish. Exposure to DEHP resulted in greater circulating concentrations of testosterone (T) and lower concentrations of estradiol (E2), which were accompanied by upregulation of Cyp17 mRNA and downregulation of Cyp19a mRNA in the gonads of females. In males, increases of T and E2 levels were consistent with upregulation of Cyp17 and Cyp19a in the gonads. Furthermore, the T/E2 ratio was increased in females but reduced in males. A significant increase in the levels of hepatic vitellogenin (VTG) gene transcription was observed in both females and males. The present study showed that waterborne exposure to DEHP altered plasma sex hormone levels and modulated gene transcription profiles of associated genes in the HPG axis and liver, occurring mostly at higher concentrations (>39.4 mu g/L), which suggests that environmental concentration of DEHP (5.4 mu g/L) alone might not disturb the endocrine system of the rare minnow in the TGR. Environ Toxicol Chem 2013;32:1846-1854. (c) 2013 SETAC
英文摘要: Great concern has been raised over the potential impact of environmental contaminants on fish populations that inhabit the Three Gorge Reservoir. The present study investigated the endocrine-disrupting effects of di-(2-ethylhexyl)-phthalate (DEHP) on the Chinese rare minnow (Gobiocypris rarus), an endemic fish distributed in upstream waters in the Yangtze River. Adult rare minnow were exposed to environmentally relevant concentrations of DEHP (0 mu g/L, 3.6 mu g/L, 12.8 mu g/L, 39.4 mu g/L, and 117.6 mu g/L) for a 21-d period. Then, concentrations of sex hormones in the plasma and relative transcription of various associated genes were measured in the hypothalamic-pituitary-gonadal (HPG) axis and liver of the fish. Exposure to DEHP resulted in greater circulating concentrations of testosterone (T) and lower concentrations of estradiol (E2), which were accompanied by upregulation of Cyp17 mRNA and downregulation of Cyp19a mRNA in the gonads of females. In males, increases of T and E2 levels were consistent with upregulation of Cyp17 and Cyp19a in the gonads. Furthermore, the T/E2 ratio was increased in females but reduced in males. A significant increase in the levels of hepatic vitellogenin (VTG) gene transcription was observed in both females and males. The present study showed that waterborne exposure to DEHP altered plasma sex hormone levels and modulated gene transcription profiles of associated genes in the HPG axis and liver, occurring mostly at higher concentrations (>39.4 mu g/L), which suggests that environmental concentration of DEHP (5.4 mu g/L) alone might not disturb the endocrine system of the rare minnow in the TGR. Environ Toxicol Chem 2013;32:1846-1854. (c) 2013 SETAC
关键词[WOS]: PHTHALIC-ACID ESTERS ; PITUITARY-GONADAL AXIS ; GENE-EXPRESSION ; PIMEPHALES-PROMELAS ; CYPRINUS-CARPIO ; FATHEAD MINNOWS ; BISPHENOL-A ; TOXICITY ; RECEPTOR ; RATS
语种: 英语
项目资助者: Science and Technology Research Project of China Three Gorges Corporation(07011034)
WOS记录号: WOS:000321549200022
ISSN号: 0730-7268
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/19595
Appears in Collections:水环境工程研究中心_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.China Three Gorges Corp, Inst Chinese Sturgeon Res, Yichang, Hubei, Peoples R China

Recommended Citation:
Wang, Xiaofang; Yang, Yuanjin; Zhang, Liping; Ma, Yanbo; Han, Jian; Yang, Lihua; Zhou, Bingsheng.Endocrine disruption by di-(2-ethylhexyl)-phthalate in Chinese rare minnow (Gobiocypris rarus),ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY,2013,32(8):1846-1854
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