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Lineage-Specific Expansion of IFIT Gene Family: An Insight into Coevolution with IFN Gene Family
Liu, Ying; Zhang, Yi-Bing; Liu, Ting-Kai; Gui, Jian-Fang; Zhang, YB (reprint author), Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Peoples R China.
2013-06-20
Source PublicationPLOS ONE
ISSN1932-6203
Volume8Issue:6Pages:e66859
AbstractIn mammals, IFIT (Interferon [IFN]-induced proteins with Tetratricopeptide Repeat [TPR] motifs) family genes are involved in many cellular and viral processes, which are tightly related to mammalian IFN response. However, little is known about non-mammalian IFIT genes. In the present study, IFIT genes are identified in the genome databases from the jawed vertebrates including the cartilaginous elephant shark but not from non-vertebrates such as lancelet, sea squirt and acorn worm, suggesting that IFIT gene family originates from a vertebrate ancestor about 450 million years ago. IFIT family genes show conserved gene structure and gene arrangements. Phylogenetic analyses reveal that this gene family has expanded through lineage-specific and species-specific gene duplication. Interestingly, IFN gene family seem to share a common ancestor and a similar evolutionary mechanism; the function link of IFIT genes to IFN response is present early since the origin of both gene families, as evidenced by the finding that zebrafish IFIT genes are upregulated by fish IFNs, poly(I:C) and two transcription factors IRF3/IRF7, likely via the IFN-stimulated response elements (ISRE) within the promoters of vertebrate IFIT family genes. These coevolution features creates functional association of both family genes to fulfill a common biological process, which is likely selected by viral infection during evolution of vertebrates. Our results are helpful for understanding of evolution of vertebrate IFN system.; In mammals, IFIT (Interferon [IFN]-induced proteins with Tetratricopeptide Repeat [TPR] motifs) family genes are involved in many cellular and viral processes, which are tightly related to mammalian IFN response. However, little is known about non-mammalian IFIT genes. In the present study, IFIT genes are identified in the genome databases from the jawed vertebrates including the cartilaginous elephant shark but not from non-vertebrates such as lancelet, sea squirt and acorn worm, suggesting that IFIT gene family originates from a vertebrate ancestor about 450 million years ago. IFIT family genes show conserved gene structure and gene arrangements. Phylogenetic analyses reveal that this gene family has expanded through lineage-specific and species-specific gene duplication. Interestingly, IFN gene family seem to share a common ancestor and a similar evolutionary mechanism; the function link of IFIT genes to IFN response is present early since the origin of both gene families, as evidenced by the finding that zebrafish IFIT genes are upregulated by fish IFNs, poly(I:C) and two transcription factors IRF3/IRF7, likely via the IFN-stimulated response elements (ISRE) within the promoters of vertebrate IFIT family genes. These coevolution features creates functional association of both family genes to fulfill a common biological process, which is likely selected by viral infection during evolution of vertebrates. Our results are helpful for understanding of evolution of vertebrate IFN system.
SubtypeArticle
KeywordInterferon-stimulated Genes Double-stranded-rna Dependent Protein-kinase Innate Immune-response Carp Carassius-auratus Antiviral Response Inducible Protein Messenger-rna i Ifns Fish
Department[Liu, Ying; Zhang, Yi-Bing; Liu, Ting-Kai; Gui, Jian-Fang] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Peoples R China
DOI10.1371/journal.pone.0066859
WOS HeadingsScience & Technology
Funding Organization973 National Basic Research Program of China [2010CB126303]; National Natural Science Foundation of China [31272690, 31172435] ; 973 National Basic Research Program of China [2010CB126303]; National Natural Science Foundation of China [31272690, 31172435] ; 973 National Basic Research Program of China [2010CB126303]; National Natural Science Foundation of China [31272690, 31172435] ; 973 National Basic Research Program of China [2010CB126303]; National Natural Science Foundation of China [31272690, 31172435]
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000322342800106
WOS KeywordINTERFERON-STIMULATED GENES ; DOUBLE-STRANDED-RNA ; DEPENDENT PROTEIN-KINASE ; INNATE IMMUNE-RESPONSE ; CARP CARASSIUS-AURATUS ; ANTIVIRAL RESPONSE ; INDUCIBLE PROTEIN ; MESSENGER-RNA ; I IFNS ; FISH
Funding Organization973 National Basic Research Program of China [2010CB126303]; National Natural Science Foundation of China [31272690, 31172435] ; 973 National Basic Research Program of China [2010CB126303]; National Natural Science Foundation of China [31272690, 31172435] ; 973 National Basic Research Program of China [2010CB126303]; National Natural Science Foundation of China [31272690, 31172435] ; 973 National Basic Research Program of China [2010CB126303]; National Natural Science Foundation of China [31272690, 31172435]
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Cited Times:24[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/19583
Collection鱼类生物学及渔业生物技术研究中心_期刊论文
Corresponding AuthorZhang, YB (reprint author), Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Peoples R China.
AffiliationChinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Peoples R China
Recommended Citation
GB/T 7714
Liu, Ying,Zhang, Yi-Bing,Liu, Ting-Kai,et al. Lineage-Specific Expansion of IFIT Gene Family: An Insight into Coevolution with IFN Gene Family[J]. PLOS ONE,2013,8(6):e66859.
APA Liu, Ying,Zhang, Yi-Bing,Liu, Ting-Kai,Gui, Jian-Fang,&Zhang, YB .(2013).Lineage-Specific Expansion of IFIT Gene Family: An Insight into Coevolution with IFN Gene Family.PLOS ONE,8(6),e66859.
MLA Liu, Ying,et al."Lineage-Specific Expansion of IFIT Gene Family: An Insight into Coevolution with IFN Gene Family".PLOS ONE 8.6(2013):e66859.
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