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题名: Phylogenetic analysis of vertebrate CXC chemokines reveals novel lineage specific groups in teleost fish
作者: Chen, Jun1, 2; Xu, Qiaoqing1, 3; Wang, Tiehui1; Collet, Bertrand4; Corripio-Miyar, Yolanda1; Bird, Steve1, 5; Xie, Ping2; Nie, Pin2; Secombes, Christopher J.1; Zou, Jun1
通讯作者: Secombes, CJ (reprint author), Univ Aberdeen, Sch Biol Sci, Scottish Fish Immunol Res Ctr, Aberdeen AB24 2TZ, Scotland.
关键词: Fish ; Teleosts ; Vertebrates ; CXC chemokines
刊名: DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
发表日期: 2013-10-01
DOI: 10.1016/j.dci.2013.05.006
卷: 41, 期:2, 页:137-152
收录类别: SCI
文章类型: Article
部门归属: [Chen, Jun ; Xu, Qiaoqing ; Wang, Tiehui ; Corripio-Miyar, Yolanda ; Bird, Steve ; Secombes, Christopher J. ; Zou, Jun] Univ Aberdeen, Sch Biol Sci, Scottish Fish Immunol Res Ctr, Aberdeen AB24 2TZ, Scotland ; [Chen, Jun ; Xie, Ping ; Nie, Pin] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China ; [Xu, Qiaoqing] Yangtze Univ, Sch Anim Sci, Jinzhou 434020, Hubei Province, Peoples R China ; [Collet, Bertrand] Marine Scotland Sci, Aberdeen AB11 9DB, Scotland ; [Bird, Steve] Univ Waikato, Sch Biol Sci, Dept Sci & Engn, Hamilton 3240, New Zealand
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
资助者: Royal Society of Edinburgh; National Natural Science Foundation of China; Leverhulme Trust; 973 National Basic Research Program of China [2009CB118703]
类目[WOS]: Immunology ; Zoology
研究领域[WOS]: Immunology ; Zoology
摘要: In this study, we have identified 421 molecules across the vertebrate spectrum and propose a unified nomenclature for CXC chemokines in fish, amphibians and reptiles based on phylogenetic analysis. Expanding on earlier studies in teleost fish, lineage specific CXC chemokines that have no apparent homologues in mammals were confirmed. Furthermore, in addition to the two subgroups of the CXCL8 homologues known in teleost fish, a third group was identified (termed CXCL8_L3), as was a further subgroup of the fish CXC genes related to CXCL11. Expression of the CXC chemokines found in rainbow trout, Oncorhynchus mykiss, was studied in response to stimulation with inflammatory and antiviral cytokines, and bacterial. Tissue distribution analysis revealed distinct expression profiles for these trout CXC chemokines. Lastly three of the trout chemokines, including two novel fish specific CXC chemokines containing three pairs of cysteines, were produced as recombinant proteins and their effect on trout leucocyte migration studied. These molecules increased the relative expression of CD4 and MCSFR in migrated cells in an in vitro chemotaxis assay. (C) 2013 Elsevier Ltd. All rights reserved.
英文摘要: In this study, we have identified 421 molecules across the vertebrate spectrum and propose a unified nomenclature for CXC chemokines in fish, amphibians and reptiles based on phylogenetic analysis. Expanding on earlier studies in teleost fish, lineage specific CXC chemokines that have no apparent homologues in mammals were confirmed. Furthermore, in addition to the two subgroups of the CXCL8 homologues known in teleost fish, a third group was identified (termed CXCL8_L3), as was a further subgroup of the fish CXC genes related to CXCL11. Expression of the CXC chemokines found in rainbow trout, Oncorhynchus mykiss, was studied in response to stimulation with inflammatory and antiviral cytokines, and bacterial. Tissue distribution analysis revealed distinct expression profiles for these trout CXC chemokines. Lastly three of the trout chemokines, including two novel fish specific CXC chemokines containing three pairs of cysteines, were produced as recombinant proteins and their effect on trout leucocyte migration studied. These molecules increased the relative expression of CD4 and MCSFR in migrated cells in an in vitro chemotaxis assay. (C) 2013 Elsevier Ltd. All rights reserved.
关键词[WOS]: TROUT ONCORHYNCHUS-MYKISS ; PRO-INFLAMMATORY CYTOKINES ; RAINBOW-TROUT ; MOLECULAR CHARACTERIZATION ; EDWARDSIELLA-ICTALURI ; EXPRESSION ANALYSIS ; CC CHEMOKINES ; IFN-GAMMA ; IDENTIFICATION ; INTERLEUKIN-8
语种: 英语
WOS记录号: WOS:000323870800005
ISSN号: 0145-305X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/19569
Appears in Collections:淡水生态学研究中心_期刊论文

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作者单位: 1.Univ Aberdeen, Sch Biol Sci, Scottish Fish Immunol Res Ctr, Aberdeen AB24 2TZ, Scotland
2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
3.Yangtze Univ, Sch Anim Sci, Jinzhou 434020, Hubei Province, Peoples R China
4.Marine Scotland Sci, Aberdeen AB11 9DB, Scotland
5.Univ Waikato, Sch Biol Sci, Dept Sci & Engn, Hamilton 3240, New Zealand

Recommended Citation:
Chen, Jun; Xu, Qiaoqing; Wang, Tiehui; Collet, Bertrand; Corripio-Miyar, Yolanda; Bird, Steve; Xie, Ping; Nie, Pin; Secombes, Christopher J.; Zou, Jun.Phylogenetic analysis of vertebrate CXC chemokines reveals novel lineage specific groups in teleost fish,DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2013,41(2):137-152
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