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题名: Tetrahymena Functional Genomics Database (TetraFGD): an integrated resource for Tetrahymena functional genomics
作者: Xiong, Jie1; Lu, Yuming1; Feng, Jinmei1, 2; Yuan, Dongxia1; Tian, Miao1, 3; Chang, Yue1, 3; Fu, Chengjie1; Wang, Guangying1, 3; Zeng, Honghui1; Miao, Wei1
通讯作者: Zeng, HH (reprint author), Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China.
关键词: GENE-EXPRESSION ; RNA ; SEQUENCE ; PROTEIN
刊名: DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION
发表日期: 2013-03-12
DOI: 10.1093/database/bat008
期: -, 页:bat008
收录类别: SCI
文章类型: Article
部门归属: [Xiong, Jie; Lu, Yuming; Feng, Jinmei; Yuan, Dongxia; Tian, Miao; Chang, Yue; Fu, Chengjie; Wang, Guangying; Zeng, Honghui; Miao, Wei] Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China; [Feng, Jinmei] Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming 650223, Peoples R China; [Tian, Miao; Chang, Yue; Wang, Guangying] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
资助者: Knowledge Innovation Program of CAS [KSCX2-EW-G-6-4]; Scientific Research Foundation for the Returned Overseas Chinese Scholars State Education Ministry; open foundation of the State Key Laboratory of Genetics Resources and Evolution [GREKF10-09]; National Scientific Data Sharing Platform for population and health, biologic medicine information center of China [2005DKA32402]
类目[WOS]: Mathematical & Computational Biology
研究领域[WOS]: Mathematical & Computational Biology
摘要: The ciliated protozoan Tetrahymena thermophila is a useful unicellular model organism for studies of eukaryotic cellular and molecular biology. Researches on T. thermophila have contributed to a series of remarkable basic biological principles. After the macronuclear genome was sequenced, substantial progress has been made in functional genomics research on T. thermophila, including genome-wide microarray analysis of the T. thermophila life cycle, a T. thermophila gene network analysis based on the microarray data and transcriptome analysis by deep RNA sequencing. To meet the growing demands for the Tetrahymena research community, we integrated these data to provide a public access database: Tetrahymena functional genomics database (TetraFGD). TetraFGD contains three major resources, including the RNA-Seq transcriptome, microarray and gene networks. The RNA-Seq data define gene structures and transcriptome, with special emphasis on exon-intron boundaries; the microarray data describe gene expression of 20 time points during three major stages of the T. thermophila life cycle; the gene network data identify potential gene-gene interactions of 15 049 genes. The TetraFGD provides user-friendly search functions that assist researchers in accessing gene models, transcripts, gene expression data and gene-gene relationships. In conclusion, the TetraFGD is an important functional genomic resource for researchers who focus on the Tetrahymena or other ciliates.
英文摘要: The ciliated protozoan Tetrahymena thermophila is a useful unicellular model organism for studies of eukaryotic cellular and molecular biology. Researches on T. thermophila have contributed to a series of remarkable basic biological principles. After the macronuclear genome was sequenced, substantial progress has been made in functional genomics research on T. thermophila, including genome-wide microarray analysis of the T. thermophila life cycle, a T. thermophila gene network analysis based on the microarray data and transcriptome analysis by deep RNA sequencing. To meet the growing demands for the Tetrahymena research community, we integrated these data to provide a public access database: Tetrahymena functional genomics database (TetraFGD). TetraFGD contains three major resources, including the RNA-Seq transcriptome, microarray and gene networks. The RNA-Seq data define gene structures and transcriptome, with special emphasis on exon-intron boundaries; the microarray data describe gene expression of 20 time points during three major stages of the T. thermophila life cycle; the gene network data identify potential gene-gene interactions of 15 049 genes. The TetraFGD provides user-friendly search functions that assist researchers in accessing gene models, transcripts, gene expression data and gene-gene relationships. In conclusion, the TetraFGD is an important functional genomic resource for researchers who focus on the Tetrahymena or other ciliates.
关键词[WOS]: GENE-EXPRESSION ; RNA ; SEQUENCE ; PROTEIN
语种: 英语
项目资助者: Knowledge Innovation Program of CAS(KSCX2-EW-G-6-4) ; Scientific Research Foundation for the Returned Overseas Chinese Scholars State Education Ministry ; open foundation of the State Key Laboratory of Genetics Resources and Evolution(GREKF10-09) ; National Scientific Data Sharing Platform for population and health, biologic medicine information center of China(2005DKA32402)
WOS记录号: WOS:000316173800001
ISSN号: 1758-0463
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内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/19339
Appears in Collections:水生生物分子与细胞生物学研究中心_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China
2.Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming 650223, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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