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题名: Effects of acute exposure to polybrominated diphenyl ethers on retinoid signaling in zebrafish larvae
作者: Xu, Tao1; Chen, Lianguo2; Hu, Chenyan2; Zhou, Bingsheng2
通讯作者: Chen, LG (reprint author), Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China.
关键词: Polybrominated diphenyl ethers ; Retinoid signaling ; Retinoic acid ; Rhodopsin ; Zebrafish embryos
刊名: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
发表日期: 2013
DOI: 10.1016/j.etap.2012.10.004
卷: 35, 期:1, 页:13-20
收录类别: SCI
文章类型: Article
部门归属: [Xu, Tao] Huazhong Univ Sci & Technol, Puai Hosp, Wuhan 430033, Peoples R China ; [Chen, Lianguo ; Hu, Chenyan ; Zhou, Bingsheng] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
资助者: National Natural Science Foundation of China [20890113]; State Key Laboratory of Freshwater Ecology and Biotechnology [2012FB17]
类目[WOS]: Environmental Sciences ; Pharmacology & Pharmacy ; Toxicology
研究领域[WOS]: Environmental Sciences & Ecology ; Pharmacology & Pharmacy ; Toxicology
摘要: The objectives of the present study were to investigate the effects of acute exposure to PBDEs on retinoid signaling in fish. Zebrafish embryos (2 h post-fertilization, hpf) were exposed to DE-71 (0, 31.0, 68.7, and 227.6 mu g/L) until 120 hpf. Retinoid profiles showed the content of retinal and retinoic acid was reduced significantly. While a significant up-regulation was observed in the transcription of retinal dehydrogenase (raldh2), the transcription of retinol binding protein (rbp1a), retinol dehydrogenase (rdh1), cellular retinoic acid binding protein.(crabp1a and crabp2a) and retinoic acid receptor subunit (raraa) were down-regulated significantly, indicating disruption of retinoid signaling. However, the transcriptions of five opsin genes (zfrho, zfuv, zfred, zfblue, and zfgr1) were up-regulated. Furthermore, whole mount immunostaining and western blotting demonstrated increased rhodopsin protein expression in the exposure groups. Overall, the results indicated that acute exposure to PBDEs could disturb retinoid signaling and may impact on eye development of zebrafish larvae. (C) 2012 Elsevier B.V. All rights reserved.
英文摘要: The objectives of the present study were to investigate the effects of acute exposure to PBDEs on retinoid signaling in fish. Zebrafish embryos (2 h post-fertilization, hpf) were exposed to DE-71 (0, 31.0, 68.7, and 227.6 mu g/L) until 120 hpf. Retinoid profiles showed the content of retinal and retinoic acid was reduced significantly. While a significant up-regulation was observed in the transcription of retinal dehydrogenase (raldh2), the transcription of retinol binding protein (rbp1a), retinol dehydrogenase (rdh1), cellular retinoic acid binding protein.(crabp1a and crabp2a) and retinoic acid receptor subunit (raraa) were down-regulated significantly, indicating disruption of retinoid signaling. However, the transcriptions of five opsin genes (zfrho, zfuv, zfred, zfblue, and zfgr1) were up-regulated. Furthermore, whole mount immunostaining and western blotting demonstrated increased rhodopsin protein expression in the exposure groups. Overall, the results indicated that acute exposure to PBDEs could disturb retinoid signaling and may impact on eye development of zebrafish larvae. (C) 2012 Elsevier B.V. All rights reserved.
关键词[WOS]: BROMINATED FLAME RETARDANTS ; VITAMIN-A ; GENE-EXPRESSION ; MATERNAL TRANSFER ; PHOTORECEPTOR DEVELOPMENT ; ENVIRONMENTAL-POLLUTANTS ; EMBRYONIC-DEVELOPMENT ; THYROID-HORMONE ; DANIO-RERIO ; ACID
语种: 英语
WOS记录号: WOS:000314262300002
ISSN号: 1382-6689
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/19330
Appears in Collections:水环境工程研究中心_期刊论文

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作者单位: 1.Huazhong Univ Sci & Technol, Puai Hosp, Wuhan 430033, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China

Recommended Citation:
Xu, T; Chen, LG; Hu, CY; Zhou, BS.Effects of acute exposure to polybrominated diphenyl ethers on retinoid signaling in zebrafish larvae,ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2013,35(1):13-20
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