IHB OpenIR  > 鱼类生物学及渔业生物技术研究中心  > 期刊论文
Polymorphisms in Myostatin Gene and Associations with Growth Traits in the Common Carp (Cyprinus carpio L.)
Sun, Yanhong1,2; Yu, Xiaomu1; Tong, Jingou1; Tong, JG (reprint author), Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan 430072, Peoples R China.
2012-11-01
Source PublicationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
ISSN1422-0067
Volume13Issue:11Pages:14956-14961
AbstractMyostatin (MSTN) is a member of the transforming growth factor-beta superfamily that negatively regulates skeletal muscle development and growth. In the present study, partial genomic fragments of MSTN were screened for single nucleotide polymorphisms (SNPs) in selected common carp individuals from wild populations, and two SNPs in intron 2 (c.371 + 749A > G, c.371 + 781T > C) and two synonymous SNPs in exon 3 (c.42A > G, c.72C > T) were identified. Genotyping by direct sequencing of polymerase chain reaction (PCR) products for these four SNPs were performed in 162 individuals from a commercial hatchery population. Association analysis showed that two SNPs in exon 3 were significantly associated with body weight (BW) and condition factor (K), and haplotype analyses revealed that haplotype H7H8 showed better growth performance. Our results demonstrated that some of the SNPs in MSTN may have positive effects on growth traits and suggested that MSTN could be a candidate gene for growth and marker-assisted selection in common carp.; Myostatin (MSTN) is a member of the transforming growth factor-beta superfamily that negatively regulates skeletal muscle development and growth. In the present study, partial genomic fragments of MSTN were screened for single nucleotide polymorphisms (SNPs) in selected common carp individuals from wild populations, and two SNPs in intron 2 (c.371 + 749A > G, c.371 + 781T > C) and two synonymous SNPs in exon 3 (c.42A > G, c.72C > T) were identified. Genotyping by direct sequencing of polymerase chain reaction (PCR) products for these four SNPs were performed in 162 individuals from a commercial hatchery population. Association analysis showed that two SNPs in exon 3 were significantly associated with body weight (BW) and condition factor (K), and haplotype analyses revealed that haplotype H7H8 showed better growth performance. Our results demonstrated that some of the SNPs in MSTN may have positive effects on growth traits and suggested that MSTN could be a candidate gene for growth and marker-assisted selection in common carp.
SubtypeArticle
KeywordMyostatin (Mstn) Single Nucleotide Polymorphisms (Snps) Common Carp (Cyprinus Carpio L.) Growth Traits Association Analysis
Department[Sun, Yanhong ; Yu, Xiaomu ; Tong, Jingou] Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan 430072, Peoples R China ; [Sun, Yanhong] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
DOI10.3390/ijms131114956
WOS HeadingsScience & Technology ; Physical Sciences
Funding OrganizationMinistry of Science and Technology [2010CB126305]; Minstry of Agriculture [2011-G12]; State Key Laboratory of Freshwater Ecology and Biotechnology of China [2011 FBZ20] ; Ministry of Science and Technology [2010CB126305]; Minstry of Agriculture [2011-G12]; State Key Laboratory of Freshwater Ecology and Biotechnology of China [2011 FBZ20] ; Ministry of Science and Technology [2010CB126305]; Minstry of Agriculture [2011-G12]; State Key Laboratory of Freshwater Ecology and Biotechnology of China [2011 FBZ20] ; Ministry of Science and Technology [2010CB126305]; Minstry of Agriculture [2011-G12]; State Key Laboratory of Freshwater Ecology and Biotechnology of China [2011 FBZ20]
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000311425000073
WOS KeywordSHEEP OVIS-ARIES ; MSTN ; IDENTIFICATION ; POPULATION ; FATNESS ; WEIGHT ; REGION
Funding OrganizationMinistry of Science and Technology [2010CB126305]; Minstry of Agriculture [2011-G12]; State Key Laboratory of Freshwater Ecology and Biotechnology of China [2011 FBZ20] ; Ministry of Science and Technology [2010CB126305]; Minstry of Agriculture [2011-G12]; State Key Laboratory of Freshwater Ecology and Biotechnology of China [2011 FBZ20] ; Ministry of Science and Technology [2010CB126305]; Minstry of Agriculture [2011-G12]; State Key Laboratory of Freshwater Ecology and Biotechnology of China [2011 FBZ20] ; Ministry of Science and Technology [2010CB126305]; Minstry of Agriculture [2011-G12]; State Key Laboratory of Freshwater Ecology and Biotechnology of China [2011 FBZ20]
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Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/19316
Collection鱼类生物学及渔业生物技术研究中心_期刊论文
Corresponding AuthorTong, JG (reprint author), Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan 430072, Peoples R China.
Affiliation1.Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan 430072, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Sun, Yanhong,Yu, Xiaomu,Tong, Jingou,et al. Polymorphisms in Myostatin Gene and Associations with Growth Traits in the Common Carp (Cyprinus carpio L.)[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2012,13(11):14956-14961.
APA Sun, Yanhong,Yu, Xiaomu,Tong, Jingou,&Tong, JG .(2012).Polymorphisms in Myostatin Gene and Associations with Growth Traits in the Common Carp (Cyprinus carpio L.).INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,13(11),14956-14961.
MLA Sun, Yanhong,et al."Polymorphisms in Myostatin Gene and Associations with Growth Traits in the Common Carp (Cyprinus carpio L.)".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 13.11(2012):14956-14961.
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