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题名: Polymorphisms in Myostatin Gene and Associations with Growth Traits in the Common Carp (Cyprinus carpio L.)
作者: Sun, Yanhong1, 2; Yu, Xiaomu1; Tong, Jingou1
通讯作者: Tong, JG (reprint author), Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan 430072, Peoples R China.
关键词: Myostatin (MSTN) ; single nucleotide polymorphisms (SNPs) ; common carp (Cyprinus carpio L.) ; growth traits ; association analysis
刊名: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
发表日期: 2012-11-01
DOI: 10.3390/ijms131114956
卷: 13, 期:11, 页:14956-14961
收录类别: SCI
文章类型: Article
部门归属: [Sun, Yanhong ; Yu, Xiaomu ; Tong, Jingou] Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan 430072, Peoples R China ; [Sun, Yanhong] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
WOS标题词: Science & Technology ; Physical Sciences
资助者: Ministry of Science and Technology [2010CB126305]; Minstry of Agriculture [2011-G12]; State Key Laboratory of Freshwater Ecology and Biotechnology of China [2011 FBZ20]
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
摘要: Myostatin (MSTN) is a member of the transforming growth factor-beta superfamily that negatively regulates skeletal muscle development and growth. In the present study, partial genomic fragments of MSTN were screened for single nucleotide polymorphisms (SNPs) in selected common carp individuals from wild populations, and two SNPs in intron 2 (c.371 + 749A > G, c.371 + 781T > C) and two synonymous SNPs in exon 3 (c.42A > G, c.72C > T) were identified. Genotyping by direct sequencing of polymerase chain reaction (PCR) products for these four SNPs were performed in 162 individuals from a commercial hatchery population. Association analysis showed that two SNPs in exon 3 were significantly associated with body weight (BW) and condition factor (K), and haplotype analyses revealed that haplotype H7H8 showed better growth performance. Our results demonstrated that some of the SNPs in MSTN may have positive effects on growth traits and suggested that MSTN could be a candidate gene for growth and marker-assisted selection in common carp.
英文摘要: Myostatin (MSTN) is a member of the transforming growth factor-beta superfamily that negatively regulates skeletal muscle development and growth. In the present study, partial genomic fragments of MSTN were screened for single nucleotide polymorphisms (SNPs) in selected common carp individuals from wild populations, and two SNPs in intron 2 (c.371 + 749A > G, c.371 + 781T > C) and two synonymous SNPs in exon 3 (c.42A > G, c.72C > T) were identified. Genotyping by direct sequencing of polymerase chain reaction (PCR) products for these four SNPs were performed in 162 individuals from a commercial hatchery population. Association analysis showed that two SNPs in exon 3 were significantly associated with body weight (BW) and condition factor (K), and haplotype analyses revealed that haplotype H7H8 showed better growth performance. Our results demonstrated that some of the SNPs in MSTN may have positive effects on growth traits and suggested that MSTN could be a candidate gene for growth and marker-assisted selection in common carp.
关键词[WOS]: SHEEP OVIS-ARIES ; MSTN ; IDENTIFICATION ; POPULATION ; FATNESS ; WEIGHT ; REGION
语种: 英语
WOS记录号: WOS:000311425000073
ISSN号: 1422-0067
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/19316
Appears in Collections:鱼类生物学及渔业生物技术研究中心_期刊论文

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作者单位: 1.Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan 430072, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

Recommended Citation:
Sun, YH; Yu, XM; Tong, JG.Polymorphisms in Myostatin Gene and Associations with Growth Traits in the Common Carp (Cyprinus carpio L.),INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2012,13(11):14956-14961
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