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题名: Identification and expression profile of Id1 in bighead carp in response to microcystin-LR
作者: Li, Huiying1; Cai, Yan1; Xie, Ping1; Chen, Jun1; Hao, Le1; Li, Guangyu1; Xiong, Qian1
通讯作者: Xie, P (reprint author), Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China.
关键词: Id1 ; Gene identification ; mRNA expression ; Microcystin-LR ; Bighead carp
刊名: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
发表日期: 2012-09-01
DOI: 10.1016/j.etap.2012.04.011
卷: 34, 期:2, 页:324-333
收录类别: SCI
文章类型: Article
部门归属: [Li, Huiying ; Cai, Yan ; Xie, Ping ; Chen, Jun ; Hao, Le ; Li, Guangyu ; Xiong, Qian] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
资助者: National Natural Science Foundation of China [31070457]; State Key Laboratory of Freshwater Ecology and Biotechnology [2008FBZ01]
类目[WOS]: Environmental Sciences ; Pharmacology & Pharmacy ; Toxicology
研究领域[WOS]: Environmental Sciences & Ecology ; Pharmacology & Pharmacy ; Toxicology
摘要: Microcystin-LR (MCLR) is a widespread cyanotoxin produced in algal blooms, and has potent hepatotoxicity and tumor-promoting activity. We cloned the full-length cDNA of Id1 in bighead carp. The full-length Id1 cDNA was 954 bp and contained a 387 bp ORF. Bighead carp Id1 shared high identity with zebrafish Id1 amino acid sequence, and phylogenetic analysis showed that teleost Id1 evolved closely. Bighead carp Id1 constitutively expressed in all tested tissues in normal. When tested at two different time points post exposure and at 3 different MCLR doses, Id1 expression increased in a time-dependent pattern, and Id1 expression in brain was very sensitive to MCLR exposure. The present study will help us to understand more about the evolution of Id1 molecule and its role in the MCLR induced cell differentiation and cancer promoting in bighead carp. Crown Copyright (C) 2012 Published by Elsevier B.V. All rights reserved.
英文摘要: Microcystin-LR (MCLR) is a widespread cyanotoxin produced in algal blooms, and has potent hepatotoxicity and tumor-promoting activity. We cloned the full-length cDNA of Id1 in bighead carp. The full-length Id1 cDNA was 954 bp and contained a 387 bp ORF. Bighead carp Id1 shared high identity with zebrafish Id1 amino acid sequence, and phylogenetic analysis showed that teleost Id1 evolved closely. Bighead carp Id1 constitutively expressed in all tested tissues in normal. When tested at two different time points post exposure and at 3 different MCLR doses, Id1 expression increased in a time-dependent pattern, and Id1 expression in brain was very sensitive to MCLR exposure. The present study will help us to understand more about the evolution of Id1 molecule and its role in the MCLR induced cell differentiation and cancer promoting in bighead carp. Crown Copyright (C) 2012 Published by Elsevier B.V. All rights reserved.
关键词[WOS]: LOOP-HELIX PROTEINS ; CRUCIAN CARP ; DNA-BINDING ; IN-VIVO ; GENE ; EMBRYOGENESIS ; ANGIOGENESIS ; INHIBITOR ; EXTRACTS ; CANCERS
语种: 英语
WOS记录号: WOS:000313155600024
ISSN号: 1382-6689
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/19303
Appears in Collections:淡水生态学研究中心_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China

Recommended Citation:
Li, HY; Cai, Y; Xie, P; Chen, J; Hao, L; Li, GY; Xiong, Q.Identification and expression profile of Id1 in bighead carp in response to microcystin-LR,ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2012,34(2):324-333
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