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Preliminary Study of the Distribution and Accumulation of GSH/Cys Metabolites of Hepatotoxic Microcystins-RR in Common Carp from a Lake with Protracted Cyanobacterial Bloom (Lake Taihu, China)
Wu, Laiyan1,2,3; Wang, Qing1; Tao, Min1; Chen, Jun1; Ma, Zhimei1; Xie, Ping1; Xie, P (reprint author), Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Donghu South Rd 7th, Wuhan 430072, Peoples R China.
2013-03-01
Source PublicationBULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
ISSN0007-4861
Volume90Issue:3Pages:382-386
AbstractTissue distributions and seasonal dynamics of glutathione and cysteine S-conjugates of microcystin-RR in feral fish from Lake Taihu were studied. High MC-RR-Cys was found in tissues, Mean MC-RR-Cys in kidney (0.253 mu g g(-1) DW) was 4 times of that in liver (0.063 mu g g(-1) DW). Ratios of MC-RR-Cys/MC-RR in liver/kidney reached as high as 5.3/39.8, respectively, meanwhile, kidney showed low accumulation of MC-RR and higher formation efficiency of MC-RR-Cys than liver (7.51x to liver), this suggested that MC-RR-Cys were significantly accumulated with the depletion of MC-RR, and it was selectively biotransformed to MC-RR-Cys in kidney for further excretion.; Tissue distributions and seasonal dynamics of glutathione and cysteine S-conjugates of microcystin-RR in feral fish from Lake Taihu were studied. High MC-RR-Cys was found in tissues, Mean MC-RR-Cys in kidney (0.253 mu g g(-1) DW) was 4 times of that in liver (0.063 mu g g(-1) DW). Ratios of MC-RR-Cys/MC-RR in liver/kidney reached as high as 5.3/39.8, respectively, meanwhile, kidney showed low accumulation of MC-RR and higher formation efficiency of MC-RR-Cys than liver (7.51x to liver), this suggested that MC-RR-Cys were significantly accumulated with the depletion of MC-RR, and it was selectively biotransformed to MC-RR-Cys in kidney for further excretion.
SubtypeArticle
KeywordMc-rr-gsh Mc-rr-cys Common Carp Lc-ms Risk Assessment
Department[Wu, Laiyan; Wang, Qing; Tao, Min; Chen, Jun; Ma, Zhimei; Xie, Ping] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China; [Wu, Laiyan] South Cent Univ Nationality, Inst Environm Engn & Sci, Key Lab Catalysis & Mat Sci, State Ethn Affairs Commiss, Wuhan 430074, Peoples R China; [Wu, Laiyan] South Cent Univ Nationality, Inst Environm Engn & Sci, Minist Educ Chem & Mat Sci, Wuhan 430074, Peoples R China
DOI10.1007/s00128-012-0947-6
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Funding OrganizationFundamental Research Funds for the Central Universities; South Central University for Nationalities [CZQ11023]; Chinese Academy of Science [KZCX1-YW-14-6-1]; National Basic Research Program of China (973 Program) [2008CB418101] ; Fundamental Research Funds for the Central Universities; South Central University for Nationalities [CZQ11023]; Chinese Academy of Science [KZCX1-YW-14-6-1]; National Basic Research Program of China (973 Program) [2008CB418101] ; Fundamental Research Funds for the Central Universities; South Central University for Nationalities [CZQ11023]; Chinese Academy of Science [KZCX1-YW-14-6-1]; National Basic Research Program of China (973 Program) [2008CB418101] ; Fundamental Research Funds for the Central Universities; South Central University for Nationalities [CZQ11023]; Chinese Academy of Science [KZCX1-YW-14-6-1]; National Basic Research Program of China (973 Program) [2008CB418101]
Indexed BySCI
Language英语
WOS Research AreaEnvironmental Sciences & Ecology ; Toxicology
WOS SubjectEnvironmental Sciences ; Toxicology
WOS IDWOS:000316002700021
WOS KeywordGLUTATHIONE ; FISH ; LR ; IDENTIFICATION ; CONJUGATE ; TOXICITY ; DYNAMICS
Funding OrganizationFundamental Research Funds for the Central Universities; South Central University for Nationalities [CZQ11023]; Chinese Academy of Science [KZCX1-YW-14-6-1]; National Basic Research Program of China (973 Program) [2008CB418101] ; Fundamental Research Funds for the Central Universities; South Central University for Nationalities [CZQ11023]; Chinese Academy of Science [KZCX1-YW-14-6-1]; National Basic Research Program of China (973 Program) [2008CB418101] ; Fundamental Research Funds for the Central Universities; South Central University for Nationalities [CZQ11023]; Chinese Academy of Science [KZCX1-YW-14-6-1]; National Basic Research Program of China (973 Program) [2008CB418101] ; Fundamental Research Funds for the Central Universities; South Central University for Nationalities [CZQ11023]; Chinese Academy of Science [KZCX1-YW-14-6-1]; National Basic Research Program of China (973 Program) [2008CB418101]
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/19291
Collection淡水生态学研究中心_期刊论文
Corresponding AuthorXie, P (reprint author), Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Donghu South Rd 7th, Wuhan 430072, Peoples R China.
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China
2.South Cent Univ Nationality, Inst Environm Engn & Sci, Key Lab Catalysis & Mat Sci, State Ethn Affairs Commiss, Wuhan 430074, Peoples R China
3.South Cent Univ Nationality, Inst Environm Engn & Sci, Minist Educ Chem & Mat Sci, Wuhan 430074, Peoples R China
Recommended Citation
GB/T 7714
Wu, Laiyan,Wang, Qing,Tao, Min,et al. Preliminary Study of the Distribution and Accumulation of GSH/Cys Metabolites of Hepatotoxic Microcystins-RR in Common Carp from a Lake with Protracted Cyanobacterial Bloom (Lake Taihu, China)[J]. BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY,2013,90(3):382-386.
APA Wu, Laiyan.,Wang, Qing.,Tao, Min.,Chen, Jun.,Ma, Zhimei.,...&Xie, P .(2013).Preliminary Study of the Distribution and Accumulation of GSH/Cys Metabolites of Hepatotoxic Microcystins-RR in Common Carp from a Lake with Protracted Cyanobacterial Bloom (Lake Taihu, China).BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY,90(3),382-386.
MLA Wu, Laiyan,et al."Preliminary Study of the Distribution and Accumulation of GSH/Cys Metabolites of Hepatotoxic Microcystins-RR in Common Carp from a Lake with Protracted Cyanobacterial Bloom (Lake Taihu, China)".BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY 90.3(2013):382-386.
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