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题名: Preliminary Study of the Distribution and Accumulation of GSH/Cys Metabolites of Hepatotoxic Microcystins-RR in Common Carp from a Lake with Protracted Cyanobacterial Bloom (Lake Taihu, China)
作者: Wu, Laiyan1, 2, 3; Wang, Qing1; Tao, Min1; Chen, Jun1; Ma, Zhimei1; Xie, Ping1
通讯作者: Xie, P (reprint author), Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Donghu South Rd 7th, Wuhan 430072, Peoples R China.
关键词: MC-RR-GSH ; MC-RR-Cys ; Common carp ; LC-MS ; Risk assessment
刊名: BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
发表日期: 2013-03-01
DOI: 10.1007/s00128-012-0947-6
卷: 90, 期:3, 页:382-386
收录类别: SCI
文章类型: Article
部门归属: [Wu, Laiyan; Wang, Qing; Tao, Min; Chen, Jun; Ma, Zhimei; Xie, Ping] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China; [Wu, Laiyan] South Cent Univ Nationality, Inst Environm Engn & Sci, Key Lab Catalysis & Mat Sci, State Ethn Affairs Commiss, Wuhan 430074, Peoples R China; [Wu, Laiyan] South Cent Univ Nationality, Inst Environm Engn & Sci, Minist Educ Chem & Mat Sci, Wuhan 430074, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
资助者: Fundamental Research Funds for the Central Universities; South Central University for Nationalities [CZQ11023]; Chinese Academy of Science [KZCX1-YW-14-6-1]; National Basic Research Program of China (973 Program) [2008CB418101]
类目[WOS]: Environmental Sciences ; Toxicology
研究领域[WOS]: Environmental Sciences & Ecology ; Toxicology
摘要: Tissue distributions and seasonal dynamics of glutathione and cysteine S-conjugates of microcystin-RR in feral fish from Lake Taihu were studied. High MC-RR-Cys was found in tissues, Mean MC-RR-Cys in kidney (0.253 mu g g(-1) DW) was 4 times of that in liver (0.063 mu g g(-1) DW). Ratios of MC-RR-Cys/MC-RR in liver/kidney reached as high as 5.3/39.8, respectively, meanwhile, kidney showed low accumulation of MC-RR and higher formation efficiency of MC-RR-Cys than liver (7.51x to liver), this suggested that MC-RR-Cys were significantly accumulated with the depletion of MC-RR, and it was selectively biotransformed to MC-RR-Cys in kidney for further excretion.
英文摘要: Tissue distributions and seasonal dynamics of glutathione and cysteine S-conjugates of microcystin-RR in feral fish from Lake Taihu were studied. High MC-RR-Cys was found in tissues, Mean MC-RR-Cys in kidney (0.253 mu g g(-1) DW) was 4 times of that in liver (0.063 mu g g(-1) DW). Ratios of MC-RR-Cys/MC-RR in liver/kidney reached as high as 5.3/39.8, respectively, meanwhile, kidney showed low accumulation of MC-RR and higher formation efficiency of MC-RR-Cys than liver (7.51x to liver), this suggested that MC-RR-Cys were significantly accumulated with the depletion of MC-RR, and it was selectively biotransformed to MC-RR-Cys in kidney for further excretion.
关键词[WOS]: GLUTATHIONE ; FISH ; LR ; IDENTIFICATION ; CONJUGATE ; TOXICITY ; DYNAMICS
语种: 英语
WOS记录号: WOS:000316002700021
ISSN号: 0007-4861
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/19291
Appears in Collections:淡水生态学研究中心_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China
2.South Cent Univ Nationality, Inst Environm Engn & Sci, Key Lab Catalysis & Mat Sci, State Ethn Affairs Commiss, Wuhan 430074, Peoples R China
3.South Cent Univ Nationality, Inst Environm Engn & Sci, Minist Educ Chem & Mat Sci, Wuhan 430074, Peoples R China
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文件名: Preliminary Study of the Distribution and Accumulation of GSHCys Metabolites of Hepatotoxic Microcystins-RR in Common Carp from a Lake with Protracted Cyanobacterial Bloom (Lake Taihu,.pdf
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