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题名: The suppression of hematopoiesis function in Balb/c mice induced by prolonged exposure of microcystin-LR
作者: Zhou, Wenshan1, 2; Zhang, Xuezhen1; Xie, Ping1, 2; Liang, Hualei1; Zhang, Xin1, 2
通讯作者: Zhang, XZ (reprint author), Huazhong Agr Univ, Coll Fisheries, Lion Hill St 1, Wuhan 430070, Peoples R China.
关键词: Microcystin-LR ; Bone marrow cells ; Micronucleus ; Apoptosis ; Hematopoiesis ; Hematoxicology
刊名: TOXICOLOGY LETTERS
发表日期: 2013-05-23
DOI: 10.1016/j.toxlet.2013.02.011
卷: 219, 期:2, 页:194-201
收录类别: SCI
文章类型: Article
部门归属: [Zhou, Wenshan; Zhang, Xuezhen; Xie, Ping; Liang, Hualei; Zhang, Xin] Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Peoples R China; [Zhou, Wenshan; Xie, Ping; Zhang, Xin] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
资助者: National Natural Science Foundation of China [30800160]
类目[WOS]: Toxicology
研究领域[WOS]: Toxicology
摘要: Microcystins (MCs) cause normocytic anemia in patients in a hemodialysis unit in Caruaru, Brazil in 1996, but the underlying mechanisms are still unclear. In the present study, Balb/c mice were intraperitoneally injected with microcystin-LR (MC-LR) at the doses of 0.5, 2 and 8 mu/kg body weight (bw) every 48 h for 30d. After the prolonged exposure of MC-LR, significant decreases of red blood cell count (RBC), hemoglobin (Hb) and hematocrit (Ht) were observed in 2 and 8 mu g/kg bw groups, but erythrocyte mean corpuscular volume (MCV) showed no significant changes. Significantly elevated micronucleus frequency was observed in bone marrow cells (BMCs) in all MC-LR treatments. The proliferation of BMCs significantly declined in both 2 and 8 mu g/kg bw groups. Serum levels of some hematopoietic growth factors significantly changed in 8 mu g/kg bw group, mainly including granulocyte-macrophage (GM-CSF), erythropoietin (EPO), interleukin-3 (IL-3) and TNF-alpha. The transcriptional levels of these 4 genes in BMCs were also significantly changed in 8 mu g/kg bw group. MC-LR exposure significantly increased the apoptosis rates in all MC-LR treatments. The present study indicates prolonged exposure of MC-LR induces normocytic anemia, and the disturbed hematopoietic growth factors and BMCs apoptosis are responsible for this normocytic anemia. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
英文摘要: Microcystins (MCs) cause normocytic anemia in patients in a hemodialysis unit in Caruaru, Brazil in 1996, but the underlying mechanisms are still unclear. In the present study, Balb/c mice were intraperitoneally injected with microcystin-LR (MC-LR) at the doses of 0.5, 2 and 8 mu/kg body weight (bw) every 48 h for 30d. After the prolonged exposure of MC-LR, significant decreases of red blood cell count (RBC), hemoglobin (Hb) and hematocrit (Ht) were observed in 2 and 8 mu g/kg bw groups, but erythrocyte mean corpuscular volume (MCV) showed no significant changes. Significantly elevated micronucleus frequency was observed in bone marrow cells (BMCs) in all MC-LR treatments. The proliferation of BMCs significantly declined in both 2 and 8 mu g/kg bw groups. Serum levels of some hematopoietic growth factors significantly changed in 8 mu g/kg bw group, mainly including granulocyte-macrophage (GM-CSF), erythropoietin (EPO), interleukin-3 (IL-3) and TNF-alpha. The transcriptional levels of these 4 genes in BMCs were also significantly changed in 8 mu g/kg bw group. MC-LR exposure significantly increased the apoptosis rates in all MC-LR treatments. The present study indicates prolonged exposure of MC-LR induces normocytic anemia, and the disturbed hematopoietic growth factors and BMCs apoptosis are responsible for this normocytic anemia. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
关键词[WOS]: NECROSIS-FACTOR-ALPHA ; BONE-MARROW ; CYANOBACTERIA BLOOM ; MICRONUCLEUS ASSAY ; PERIPHERAL-BLOOD ; PROGENITOR CELLS ; CYTOCHROME-C ; DNA-DAMAGE ; ANEMIA ; PROLIFERATION
语种: 英语
WOS记录号: WOS:000318838300012
ISSN号: 0378-4274
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/19286
Appears in Collections:淡水生态学研究中心_期刊论文

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作者单位: 1.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China
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