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题名: The identification of apolipoprotein C-I in rare minnow (Gobiocypris rarus) and its expression following cadmium exposure
作者: Wang, Chunling1, 2, 3; Zhang, Futie1, 2; Cao, Wenxuan1, 2; Wang, Jianwei1, 2
通讯作者: Zhang, FT (reprint author), Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Hubei Province, Peoples R China.
关键词: Apolipoprotein C-I ; Cadmium ; Gene expression ; Rare minnow
刊名: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
发表日期: 2013-05-01
DOI: 10.1016/j.etap.2013.02.004
卷: 35, 期:3, 页:419-426
收录类别: SCI
文章类型: Article
部门归属: [Wang, Chunling ; Zhang, Futie ; Cao, Wenxuan ; Wang, Jianwei] Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Hubei Province, Peoples R China ; [Wang, Chunling ; Zhang, Futie ; Cao, Wenxuan ; Wang, Jianwei] Chinese Acad Sci, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Hubei Province, Peoples R China ; [Wang, Chunling] Univ Chinese Acad Sci, Beijing 100039, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
资助者: National Natural Science Foundation of China [30900154]; Knowledge Innovation Program of the Chinese Academy of Sciences [Y15E011101]; National 863 High Technology Research Program of China [2012AA06A302-4]
类目[WOS]: Environmental Sciences ; Pharmacology & Pharmacy ; Toxicology
研究领域[WOS]: Environmental Sciences & Ecology ; Pharmacology & Pharmacy ; Toxicology
摘要: Cadmium (Cd) is a ubiquitous environment contaminant that has been detected in a variety of terrestrial and aquatic organisms. In our study, rare minnow were exposed to 0.4 mg/L Cd2+ solution, fish tissues including gill, intestine, kidney, liver, muscle, and spleen were collected at 1, 6, 12,24 and 48 h after exposure. Differential expression sequence tags (ESTs) were screened and an EST similar to Hemibarbus mylodon apolipoprotein C-I (ApoC-I) was identified. The ApoC-I cDNA had been obtained with the sequence of 583 bp, which can code 84 amino acids. The transcription expression patterns of ApoC-I were compared after Cd exposure with the real-time PCR in the above tissues. ApoC-I regulation was prominent in spleen, muscle, gill and liver and moderate in kidney and intestine. This suggests a complex transcriptional regulation of ApoC-I expression following Cd exposure. (c) 2013 Elsevier B.V. All rights reserved.
英文摘要: Cadmium (Cd) is a ubiquitous environment contaminant that has been detected in a variety of terrestrial and aquatic organisms. In our study, rare minnow were exposed to 0.4 mg/L Cd2+ solution, fish tissues including gill, intestine, kidney, liver, muscle, and spleen were collected at 1, 6, 12,24 and 48 h after exposure. Differential expression sequence tags (ESTs) were screened and an EST similar to Hemibarbus mylodon apolipoprotein C-I (ApoC-I) was identified. The ApoC-I cDNA had been obtained with the sequence of 583 bp, which can code 84 amino acids. The transcription expression patterns of ApoC-I were compared after Cd exposure with the real-time PCR in the above tissues. ApoC-I regulation was prominent in spleen, muscle, gill and liver and moderate in kidney and intestine. This suggests a complex transcriptional regulation of ApoC-I expression following Cd exposure. (c) 2013 Elsevier B.V. All rights reserved.
关键词[WOS]: PERFLUOROOCTANOIC ACID ; SYNECHOGOBIUS-HASTA ; MOLECULAR-CLONING ; MULTIGENE FAMILY ; OXIDATIVE STRESS ; FISH ; RESPONSES ; GENE ; ACCUMULATION ; VITELLOGENIN
语种: 英语
WOS记录号: WOS:000317943500008
ISSN号: 1382-6689
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/19258
Appears in Collections:水生生物多样性与资源保护研究中心_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Hubei Province, Peoples R China
2.Chinese Acad Sci, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Hubei Province, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China

Recommended Citation:
Wang, CL; Zhang, FT; Cao, WX; Wang, JW.The identification of apolipoprotein C-I in rare minnow (Gobiocypris rarus) and its expression following cadmium exposure,ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2013,35(3):419-426
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