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题名: UP-REGULATING EXPRESSIONS OF TOLL-LIKE RECEPTOR 3 AND MX GENES IN GILLS BY GRASS CARP REOVIRUS IN RARE MINNOW, GOBIOCYPRIS RARUS
作者: Su Jian-Guo (so.jianguo@gmail.com) ; Zhu Zuo-Yan (zyzhu@ihb.ac.cn) ; Wang Ya-Ping
通讯作者: Zhu Zuo-Yan ; Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China
刊名: Acta Hydrobiologica Sinica
发表日期: 2008
卷: 32, 期:5, 页:728-734
收录类别: 其他
英文摘要: Exposure to the external aqueous environment enhances the susceptibility to infectious diseases in fish gills. To understand the mechanism of local innate immunity against infectious grass carp reovirus ( GCRV) in the gills, we identified the partial cDNA sequence of Mx, an antiviral effector molecule, in rare minnow Gobiocypris rarus. Real-time quantitative RT-PCR ( qRT-PCR) was employed to quantitate rnRNA levels of a pattern recognition receptor, Toll-like receptor 3 ( TLR3), and type 1 interferons indicator molecule Mx. The artificial infection experiments revealed that TLR3 and Mx mRNA expressions were simultaneously significant tip-regulation at 12h postinjection ( p 0.05), the transcription level of TLR3 recovered at 48h postinjection (p > 0.05), and the Mx mRNA expression kept at high transcription level till moribund (p < 0.05). These results highlighted the importance of the gills as a tissue capable of mounting a local immune response, and the interferon pathway was activated to GCRV infection.
ISSN号: 1000-3207
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/18737
Appears in Collections:中科院水生所知识产出(2009年前)_期刊论文

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Su Jian-Guo (so.jianguo@gmail.com) ; Zhu Zuo-Yan (zyzhu@ihb.ac.cn) ; Wang Ya-Ping.UP-REGULATING EXPRESSIONS OF TOLL-LIKE RECEPTOR 3 AND MX GENES IN GILLS BY GRASS CARP REOVIRUS IN RARE MINNOW, GOBIOCYPRIS RARUS,Acta Hydrobiologica Sinica,2008,32(5):728-734
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文件名: UP-REGULATING EXPRESSIONS OF TOLL-LIKE RECEPTOR 3 AND MX GENES IN GILLS BY GRASS CARP REOVIRUS IN RARE MINNOW, GOBIOCYPRIS RARUS.pdf
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