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UP-REGULATING EXPRESSIONS OF TOLL-LIKE RECEPTOR 3 AND MX GENES IN GILLS BY GRASS CARP REOVIRUS IN RARE MINNOW, GOBIOCYPRIS RARUS
Su Jian-Guo (so.jianguo@gmail.com); Zhu Zuo-Yan (zyzhu@ihb.ac.cn); Wang Ya-Ping; Zhu Zuo-Yan; Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China
2008
Source PublicationActa Hydrobiologica Sinica
ISSN1000-3207
Volume32Issue:5Pages:728-734
AbstractExposure to the external aqueous environment enhances the susceptibility to infectious diseases in fish gills. To understand the mechanism of local innate immunity against infectious grass carp reovirus ( GCRV) in the gills, we identified the partial cDNA sequence of Mx, an antiviral effector molecule, in rare minnow Gobiocypris rarus. Real-time quantitative RT-PCR ( qRT-PCR) was employed to quantitate rnRNA levels of a pattern recognition receptor, Toll-like receptor 3 ( TLR3), and type 1 interferons indicator molecule Mx. The artificial infection experiments revealed that TLR3 and Mx mRNA expressions were simultaneously significant tip-regulation at 12h postinjection ( p 0.05), the transcription level of TLR3 recovered at 48h postinjection (p > 0.05), and the Mx mRNA expression kept at high transcription level till moribund (p < 0.05). These results highlighted the importance of the gills as a tissue capable of mounting a local immune response, and the interferon pathway was activated to GCRV infection.
Indexed By其他
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/18737
Collection期刊论文
Corresponding AuthorZhu Zuo-Yan; Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China
Recommended Citation
GB/T 7714
Su Jian-Guo ,Zhu Zuo-Yan ,Wang Ya-Ping,et al. UP-REGULATING EXPRESSIONS OF TOLL-LIKE RECEPTOR 3 AND MX GENES IN GILLS BY GRASS CARP REOVIRUS IN RARE MINNOW, GOBIOCYPRIS RARUS[J]. Acta Hydrobiologica Sinica,2008,32(5):728-734.
APA Su Jian-Guo ,Zhu Zuo-Yan ,Wang Ya-Ping,Zhu Zuo-Yan,&Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China.(2008).UP-REGULATING EXPRESSIONS OF TOLL-LIKE RECEPTOR 3 AND MX GENES IN GILLS BY GRASS CARP REOVIRUS IN RARE MINNOW, GOBIOCYPRIS RARUS.Acta Hydrobiologica Sinica,32(5),728-734.
MLA Su Jian-Guo ,et al."UP-REGULATING EXPRESSIONS OF TOLL-LIKE RECEPTOR 3 AND MX GENES IN GILLS BY GRASS CARP REOVIRUS IN RARE MINNOW, GOBIOCYPRIS RARUS".Acta Hydrobiologica Sinica 32.5(2008):728-734.
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