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Evolutionary mode of metallothioneins inferred from Cd-MT genes of Tetrahymena
Wan Ming-liang (xyzwj777@yahoo.com.cn); Feng Wei-song; Miao Wei (miaowei@ihb.ac.cn); Wong Ming-hong; Miao Wei; Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol and Biotechnol, Wuhan 430072, Hubei, Peoples R China
2005
Source PublicationWuhan University Journal of Natural Sciences
ISSN1007-1202
Volume10Issue:5Pages:925-930
AbstractFrom Tetrahymena thermophila (strain BF5), the coding region of Cd-MT gene was cloned and sequenced, and identified as MTT1 isoform. A serial duplicate structure is discovered in its amino acid sequence, which separates the coding region into three parts (Part 1: 7-61; Part 2: 64-118; Part 3: 122-162). The alignments among them and comparison with the corresponding parts of MT1 isoform suggest that MT1 and MTT1 isoforms both come from the same ancient gene that is homologous to Part 1, and Cd-MTs of Tetrahymena are aroused by such ancient gene duplication. The prediction of secondary structures and the analysis of the disulfide-bonding state of cysteine show that there are a lot of differences between MT1 and MTT1 isoforms, which maybe relate to their function mechanism.
Indexed By其他
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/18485
Collection期刊论文
Corresponding AuthorMiao Wei; Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol and Biotechnol, Wuhan 430072, Hubei, Peoples R China
Recommended Citation
GB/T 7714
Wan Ming-liang ,Feng Wei-song,Miao Wei ,et al. Evolutionary mode of metallothioneins inferred from Cd-MT genes of Tetrahymena[J]. Wuhan University Journal of Natural Sciences,2005,10(5):925-930.
APA Wan Ming-liang ,Feng Wei-song,Miao Wei ,Wong Ming-hong,Miao Wei,&Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol and Biotechnol, Wuhan 430072, Hubei, Peoples R China.(2005).Evolutionary mode of metallothioneins inferred from Cd-MT genes of Tetrahymena.Wuhan University Journal of Natural Sciences,10(5),925-930.
MLA Wan Ming-liang ,et al."Evolutionary mode of metallothioneins inferred from Cd-MT genes of Tetrahymena".Wuhan University Journal of Natural Sciences 10.5(2005):925-930.
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