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题名: Evolutionary mode of metallothioneins inferred from Cd-MT genes of Tetrahymena
作者: Wan Ming-liang (xyzwj777@yahoo.com.cn) ; Feng Wei-song ; Miao Wei (miaowei@ihb.ac.cn) ; Wong Ming-hong
通讯作者: Miao Wei ; Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol and Biotechnol, Wuhan 430072, Hubei, Peoples R China
刊名: Wuhan University Journal of Natural Sciences
发表日期: 2005
卷: 10, 期:5, 页:925-930
收录类别: 其他
英文摘要: From Tetrahymena thermophila (strain BF5), the coding region of Cd-MT gene was cloned and sequenced, and identified as MTT1 isoform. A serial duplicate structure is discovered in its amino acid sequence, which separates the coding region into three parts (Part 1: 7-61; Part 2: 64-118; Part 3: 122-162). The alignments among them and comparison with the corresponding parts of MT1 isoform suggest that MT1 and MTT1 isoforms both come from the same ancient gene that is homologous to Part 1, and Cd-MTs of Tetrahymena are aroused by such ancient gene duplication. The prediction of secondary structures and the analysis of the disulfide-bonding state of cysteine show that there are a lot of differences between MT1 and MTT1 isoforms, which maybe relate to their function mechanism.
ISSN号: 1007-1202
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/18485
Appears in Collections:中科院水生所知识产出(2009年前)_期刊论文

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Wan Ming-liang (xyzwj777@yahoo.com.cn) ; Feng Wei-song; Miao Wei (miaowei@ihb.ac.cn) ; Wong Ming-hong.Evolutionary mode of metallothioneins inferred from Cd-MT genes of Tetrahymena,Wuhan University Journal of Natural Sciences,2005,10(5):925-930
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