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题名: Prenatal Transfer of Polybrominated Diphenyl Ethers (PBDEs) Results in Developmental Neurotoxicity in Zebrafish Larvae
作者: Chen, Lianguo2; Yu, Ke2; Huang, Changjiang3; Yu, Liqin2; Zhu, Bingqing1, 4, 5; Lam, Paul K. S.1, 4, 5; Lam, James C. W.1, 4, 5; Zhou, Bingsheng2
通讯作者: Lam, JCW (reprint author), City Univ Hong Kong, State Key Lab Marine Pollut, Kowloon, Hong Kong, Peoples R China.
关键词: BROMINATED FLAME RETARDANTS ; MATERNAL TRANSFER ; THYROID-HORMONE ; 2,2',4,4',5-PENTABROMODIPHENYL ETHER ; NEURONAL DEVELOPMENT ; NEONATAL EXPOSURE ; CEREBRAL-CORTEX ; SOUTH CHINA ; PROTEIN ; GROWTH
刊名: ENVIRONMENTAL SCIENCE & TECHNOLOGY
发表日期: 2012-09-04
DOI: 10.1021/es302119g
卷: 46, 期:17, 页:9727-9734
收录类别: SCI
文章类型: Article
部门归属: [Zhu, Bingqing; Lam, Paul K. S.; Lam, James C. W.] City Univ Hong Kong, State Key Lab Marine Pollut, Kowloon, Hong Kong, Peoples R China; [Chen, Lianguo; Yu, Ke; Yu, Liqin; Zhou, Bingsheng] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China; [Huang, Changjiang] Wenzhou Med Coll, Inst Watershed Sci & Environm Ecol, Wenzhou 325035, Peoples R China; [Zhu, Bingqing; Lam, Paul K. S.; Lam, James C. W.] City Univ Hong Kong, Res Ctr Oceans & Human Hlth, Shenzhen 518057, Peoples R China; [Zhu, Bingqing; Lam, Paul K. S.; Lam, James C. W.] City Univ Hong Kong, Dept Biol & Chem, Kowloon, Hong Kong, Peoples R China
WOS标题词: Science & Technology ; Technology ; Life Sciences & Biomedicine
资助者: National Natural Science Foundation of China [20890113]; Hong Kong Research Grants Council [City U 160610]; State Key Laboratory of Freshwater Ecology and Biotechnology [2011FBZ13]
类目[WOS]: Engineering, Environmental ; Environmental Sciences
研究领域[WOS]: Engineering ; Environmental Sciences & Ecology
摘要: Parental exposure to polybrominated diphenyl ethers (PBDEs) in animals has been found to be transferred to the offspring. The environmental health risk and toxicity to the offspring are still unclear. The objective of the present study was to identify environmentally relevant concentrations of for PBDEs for parental exposure that would cause developmental neurotoxicity in the offspring. Adult zebrafish were exposed to environmentally relevant concentrations of DE-71 (0.16, 0.8, 4.0 mu g/L) via water. The results showed that PBDE exposure did not affect larvae hatching, malformation, or survival. The residue of PBDEs was detected in F1 eggs upon parental exposure. Acetylcholinesterase (AChE) activity was significantly inhibited in F1 larvae. Genes of central nervous system development (e.g., myelin basic protein, synapsin ha, alpha 1-tubulin) were significantly downregulated in larvae. Protein levels of alpha 1-tubulin and synapsin Ha were also reduced. Decreased locomotion activity was observed in the larvae. This study provides the first evidence that parental exposure to environmentally relevant concentrations of PBDEs could cause adverse effects on neurodevelopment in zebrafish offspring.
英文摘要: Parental exposure to polybrominated diphenyl ethers (PBDEs) in animals has been found to be transferred to the offspring. The environmental health risk and toxicity to the offspring are still unclear. The objective of the present study was to identify environmentally relevant concentrations of for PBDEs for parental exposure that would cause developmental neurotoxicity in the offspring. Adult zebrafish were exposed to environmentally relevant concentrations of DE-71 (0.16, 0.8, 4.0 mu g/L) via water. The results showed that PBDE exposure did not affect larvae hatching, malformation, or survival. The residue of PBDEs was detected in F1 eggs upon parental exposure. Acetylcholinesterase (AChE) activity was significantly inhibited in F1 larvae. Genes of central nervous system development (e.g., myelin basic protein, synapsin ha, alpha 1-tubulin) were significantly downregulated in larvae. Protein levels of alpha 1-tubulin and synapsin Ha were also reduced. Decreased locomotion activity was observed in the larvae. This study provides the first evidence that parental exposure to environmentally relevant concentrations of PBDEs could cause adverse effects on neurodevelopment in zebrafish offspring.
关键词[WOS]: BROMINATED FLAME RETARDANTS ; MATERNAL TRANSFER ; THYROID-HORMONE ; 2,2',4,4',5-PENTABROMODIPHENYL ETHER ; NEURONAL DEVELOPMENT ; NEONATAL EXPOSURE ; CEREBRAL-CORTEX ; SOUTH CHINA ; PROTEIN ; GROWTH
语种: 英语
WOS记录号: WOS:000308260700063
ISSN号: 0013-936X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/17248
Appears in Collections:水环境工程研究中心_期刊论文

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作者单位: 1.City Univ Hong Kong, State Key Lab Marine Pollut, Kowloon, Hong Kong, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
3.Wenzhou Med Coll, Inst Watershed Sci & Environm Ecol, Wenzhou 325035, Peoples R China
4.City Univ Hong Kong, Res Ctr Oceans & Human Hlth, Shenzhen 518057, Peoples R China
5.City Univ Hong Kong, Dept Biol & Chem, Kowloon, Hong Kong, Peoples R China

Recommended Citation:
Chen, Lianguo; Yu, Ke; Huang, Changjiang; Yu, Liqin; Zhu, Bingqing; Lam, Paul K. S.; Lam, James C. W.; Zhou, Bingsheng.Prenatal Transfer of Polybrominated Diphenyl Ethers (PBDEs) Results in Developmental Neurotoxicity in Zebrafish Larvae,ENVIRONMENTAL SCIENCE & TECHNOLOGY,2012,46(17):9727-9734
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文件名: Prenatal Transfer of Polybrominated Diphenyl Ethers (PBDEs) Results in Developmental Neurotoxicity in Zebrafish Larvae.pdf
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