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Prenatal Transfer of Polybrominated Diphenyl Ethers (PBDEs) Results in Developmental Neurotoxicity in Zebrafish Larvae
Chen, Lianguo2; Yu, Ke2; Huang, Changjiang3; Yu, Liqin2; Zhu, Bingqing1,4,5; Lam, Paul K. S.1,4,5; Lam, James C. W.1,4,5; Zhou, Bingsheng2; Lam, JCW (reprint author), City Univ Hong Kong, State Key Lab Marine Pollut, Kowloon, Hong Kong, Peoples R China.
2012-09-04
Source PublicationENVIRONMENTAL SCIENCE & TECHNOLOGY
ISSN0013-936X
Volume46Issue:17Pages:9727-9734
AbstractParental exposure to polybrominated diphenyl ethers (PBDEs) in animals has been found to be transferred to the offspring. The environmental health risk and toxicity to the offspring are still unclear. The objective of the present study was to identify environmentally relevant concentrations of for PBDEs for parental exposure that would cause developmental neurotoxicity in the offspring. Adult zebrafish were exposed to environmentally relevant concentrations of DE-71 (0.16, 0.8, 4.0 mu g/L) via water. The results showed that PBDE exposure did not affect larvae hatching, malformation, or survival. The residue of PBDEs was detected in F1 eggs upon parental exposure. Acetylcholinesterase (AChE) activity was significantly inhibited in F1 larvae. Genes of central nervous system development (e.g., myelin basic protein, synapsin ha, alpha 1-tubulin) were significantly downregulated in larvae. Protein levels of alpha 1-tubulin and synapsin Ha were also reduced. Decreased locomotion activity was observed in the larvae. This study provides the first evidence that parental exposure to environmentally relevant concentrations of PBDEs could cause adverse effects on neurodevelopment in zebrafish offspring.; Parental exposure to polybrominated diphenyl ethers (PBDEs) in animals has been found to be transferred to the offspring. The environmental health risk and toxicity to the offspring are still unclear. The objective of the present study was to identify environmentally relevant concentrations of for PBDEs for parental exposure that would cause developmental neurotoxicity in the offspring. Adult zebrafish were exposed to environmentally relevant concentrations of DE-71 (0.16, 0.8, 4.0 mu g/L) via water. The results showed that PBDE exposure did not affect larvae hatching, malformation, or survival. The residue of PBDEs was detected in F1 eggs upon parental exposure. Acetylcholinesterase (AChE) activity was significantly inhibited in F1 larvae. Genes of central nervous system development (e.g., myelin basic protein, synapsin ha, alpha 1-tubulin) were significantly downregulated in larvae. Protein levels of alpha 1-tubulin and synapsin Ha were also reduced. Decreased locomotion activity was observed in the larvae. This study provides the first evidence that parental exposure to environmentally relevant concentrations of PBDEs could cause adverse effects on neurodevelopment in zebrafish offspring.
SubtypeArticle
KeywordBrominated Flame Retardants Maternal Transfer Thyroid-hormone 2,2',4,4',5-pentabromodiphenyl Ether Neuronal Development Neonatal Exposure Cerebral-cortex South China Protein Growth
Department[Zhu, Bingqing; Lam, Paul K. S.; Lam, James C. W.] City Univ Hong Kong, State Key Lab Marine Pollut, Kowloon, Hong Kong, Peoples R China; [Chen, Lianguo; Yu, Ke; Yu, Liqin; Zhou, Bingsheng] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China; [Huang, Changjiang] Wenzhou Med Coll, Inst Watershed Sci & Environm Ecol, Wenzhou 325035, Peoples R China; [Zhu, Bingqing; Lam, Paul K. S.; Lam, James C. W.] City Univ Hong Kong, Res Ctr Oceans & Human Hlth, Shenzhen 518057, Peoples R China; [Zhu, Bingqing; Lam, Paul K. S.; Lam, James C. W.] City Univ Hong Kong, Dept Biol & Chem, Kowloon, Hong Kong, Peoples R China
DOI10.1021/es302119g
WOS HeadingsScience & Technology ; Technology ; Life Sciences & Biomedicine
Funding OrganizationNational Natural Science Foundation of China [20890113]; Hong Kong Research Grants Council [City U 160610]; State Key Laboratory of Freshwater Ecology and Biotechnology [2011FBZ13] ; National Natural Science Foundation of China [20890113]; Hong Kong Research Grants Council [City U 160610]; State Key Laboratory of Freshwater Ecology and Biotechnology [2011FBZ13] ; National Natural Science Foundation of China [20890113]; Hong Kong Research Grants Council [City U 160610]; State Key Laboratory of Freshwater Ecology and Biotechnology [2011FBZ13] ; National Natural Science Foundation of China [20890113]; Hong Kong Research Grants Council [City U 160610]; State Key Laboratory of Freshwater Ecology and Biotechnology [2011FBZ13]
Indexed BySCI
Language英语
WOS Research AreaEngineering ; Environmental Sciences & Ecology
WOS SubjectEngineering, Environmental ; Environmental Sciences
WOS IDWOS:000308260700063
WOS KeywordBROMINATED FLAME RETARDANTS ; MATERNAL TRANSFER ; THYROID-HORMONE ; 2,2',4,4',5-PENTABROMODIPHENYL ETHER ; NEURONAL DEVELOPMENT ; NEONATAL EXPOSURE ; CEREBRAL-CORTEX ; SOUTH CHINA ; PROTEIN ; GROWTH
Funding OrganizationNational Natural Science Foundation of China [20890113]; Hong Kong Research Grants Council [City U 160610]; State Key Laboratory of Freshwater Ecology and Biotechnology [2011FBZ13] ; National Natural Science Foundation of China [20890113]; Hong Kong Research Grants Council [City U 160610]; State Key Laboratory of Freshwater Ecology and Biotechnology [2011FBZ13] ; National Natural Science Foundation of China [20890113]; Hong Kong Research Grants Council [City U 160610]; State Key Laboratory of Freshwater Ecology and Biotechnology [2011FBZ13] ; National Natural Science Foundation of China [20890113]; Hong Kong Research Grants Council [City U 160610]; State Key Laboratory of Freshwater Ecology and Biotechnology [2011FBZ13]
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/17248
Collection水环境工程研究中心_期刊论文
Corresponding AuthorLam, JCW (reprint author), City Univ Hong Kong, State Key Lab Marine Pollut, Kowloon, Hong Kong, Peoples R China.
Affiliation1.City Univ Hong Kong, State Key Lab Marine Pollut, Kowloon, Hong Kong, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
3.Wenzhou Med Coll, Inst Watershed Sci & Environm Ecol, Wenzhou 325035, Peoples R China
4.City Univ Hong Kong, Res Ctr Oceans & Human Hlth, Shenzhen 518057, Peoples R China
5.City Univ Hong Kong, Dept Biol & Chem, Kowloon, Hong Kong, Peoples R China
Recommended Citation
GB/T 7714
Chen, Lianguo,Yu, Ke,Huang, Changjiang,et al. Prenatal Transfer of Polybrominated Diphenyl Ethers (PBDEs) Results in Developmental Neurotoxicity in Zebrafish Larvae[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2012,46(17):9727-9734.
APA Chen, Lianguo.,Yu, Ke.,Huang, Changjiang.,Yu, Liqin.,Zhu, Bingqing.,...&Lam, JCW .(2012).Prenatal Transfer of Polybrominated Diphenyl Ethers (PBDEs) Results in Developmental Neurotoxicity in Zebrafish Larvae.ENVIRONMENTAL SCIENCE & TECHNOLOGY,46(17),9727-9734.
MLA Chen, Lianguo,et al."Prenatal Transfer of Polybrominated Diphenyl Ethers (PBDEs) Results in Developmental Neurotoxicity in Zebrafish Larvae".ENVIRONMENTAL SCIENCE & TECHNOLOGY 46.17(2012):9727-9734.
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