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题名: Molecular regulation of interferon antiviral response in fish (Review)
作者: Zhang, Yi-Bing ; Gui, Jian-Fang
通讯作者: Zhang, YB (reprint author), Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China.
关键词: Fish IFN antiviral response ; Jak-Stat signaling pathway ; TLR pathway ; RLR pathway ; Auto-regulation ; Molecular regulation
刊名: DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
发表日期: 2012
卷: 38, 期:2, 页:193-202
收录类别: SCI
部门归属: [Zhang, Yi-Bing; Gui, Jian-Fang] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
资助者: 973 National Basic Research Program of China [2010CB126303]; National Natural Science Foundation of China [31172435]; Autonomous Project of State Key Laboratory of Freshwater Ecology and Biotechnology [2011FBZ24]
摘要: Interferon (IFN) response is the first line of host defense against virus infection. The recent years have witnessed tremendous progress in understanding of fish IFN antiviral response. Varied number of IFN genes has been identified in different fish species but obviously, they do not show a one-to-one orthologous relationship with mammalian IFN homologs. These genes are divided into two groups with different abilities to induce downstream gene expression through binding to different receptor complexes. Consistently, some fish IFN-stimulated genes such as Mx and PKR have been confirmed for their antiviral effects. In this review, we focus on how fish cells respond to IFNs and how fish IFNs are triggered through TLR pathway and RLR pathway. We highlight the roles of IRF3 and IRF7 in activation of fish IFN response. In addition, the unique mechanisms underlying IRF3/7-dependent fish IFN response and auto-regulation of fish IFN gene expression are discussed. (C) 2012 Elsevier Ltd. All rights reserved.
语种: 英语
ISSN号: 0145-305X
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/17240
Appears in Collections:鱼类生物学及渔业生物技术研究中心_期刊论文

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Zhang, Yi-Bing; Gui, Jian-Fang.Molecular regulation of interferon antiviral response in fish ,DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2012,38(2):193-202
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