IHB OpenIR  > 藻类生物学及应用研究中心  > 期刊论文
Microalgae as platforms for production of recombinant proteins and valuable compounds: progress and prospects (Review)
Gong, Yangmin; Hu, Hanhua; Gao, Yuan; Xu, Xudong; Gao, Hong; Gao, H (reprint author), Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China.
2011
Source PublicationJOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
ISSN1367-5435
Volume38Issue:12Pages:1879-1890
AbstractOver the last few years microalgae have gained increasing interest as a natural source of valuable compounds and as bioreactors for recombinant protein production. Natural high-value compounds including pigments, long-chain polyunsaturated fatty acids, and polysaccharides, which have a wide range of applications in the food, feed, cosmetics, and pharmaceutical industries, are currently produced with nontransgenic microalgae. However, transgenic microalgae can be used as bioreactors for the production of therapeutic and industrially relevant recombinant proteins. This technology shows great promise to simplify the production process and signiWcantly decrease the production costs. To date, a variety of recombinant proteins have been produced experimentally from the nuclear or chloroplast genome of transgenic Chlamydomonas reinhardtii. These include monoclonal antibodies, vaccines, hormones, pharmaceutical proteins, and others. In this review, we outline recent progress in the production of recombinant proteins with transgenic microalgae as bioreactors, methods for genetic transformation of microalgae, and strategies for highly efficient expression of heterologous genes. In particular, we highlight the importance of maximizing the value of transgenic microalgae through producing recombinant proteins together with recovery of natural high-value compounds. Finally, we outline some important issues that need to be addressed before commercial-scale production of high-value recombinant proteins and compounds from transgenic microalgae can be realized.
KeywordMicroalgae Chlamydomonas Reinhardtii Phaeodactylum Tricornutum Chlorella Sp. Recombinant Proteins Valuable Compounds Genetic Transformation Transgene
Department[Gong, Yangmin; Hu, Hanhua; Gao, Yuan; Xu, Xudong; Gao, Hong] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
Funding OrganizationIndependent Foundation of the National Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences[2008FBZ19] ; Independent Foundation of the National Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences[2008FBZ19] ; Independent Foundation of the National Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences[2008FBZ19] ; Independent Foundation of the National Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences[2008FBZ19]
Indexed BySCI
Language英语
Funding OrganizationIndependent Foundation of the National Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences[2008FBZ19] ; Independent Foundation of the National Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences[2008FBZ19] ; Independent Foundation of the National Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences[2008FBZ19] ; Independent Foundation of the National Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences[2008FBZ19]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/17061
Collection藻类生物学及应用研究中心_期刊论文
Corresponding AuthorGao, H (reprint author), Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China.
Recommended Citation
GB/T 7714
Gong, Yangmin,Hu, Hanhua,Gao, Yuan,et al. Microalgae as platforms for production of recombinant proteins and valuable compounds: progress and prospects (Review)[J]. JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY,2011,38(12):1879-1890.
APA Gong, Yangmin,Hu, Hanhua,Gao, Yuan,Xu, Xudong,Gao, Hong,&Gao, H .(2011).Microalgae as platforms for production of recombinant proteins and valuable compounds: progress and prospects (Review).JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY,38(12),1879-1890.
MLA Gong, Yangmin,et al."Microalgae as platforms for production of recombinant proteins and valuable compounds: progress and prospects (Review)".JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY 38.12(2011):1879-1890.
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