中国科学院水生生物研究所机构知识库
Advanced  
IHB OpenIR  > 藻类生物学及应用研究中心  > 期刊论文
题名: Microalgae as platforms for production of recombinant proteins and valuable compounds: progress and prospects (Review)
作者: Gong, Yangmin ; Hu, Hanhua ; Gao, Yuan ; Xu, Xudong ; Gao, Hong
通讯作者: Gao, H (reprint author), Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China.
关键词: Microalgae ; Chlamydomonas reinhardtii ; Phaeodactylum tricornutum ; Chlorella sp. ; Recombinant proteins ; Valuable compounds ; Genetic transformation ; Transgene
刊名: JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
发表日期: 2011
卷: 38, 期:12, 页:1879-1890
收录类别: SCI
部门归属: [Gong, Yangmin; Hu, Hanhua; Gao, Yuan; Xu, Xudong; Gao, Hong] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
资助者: Independent Foundation of the National Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences[2008FBZ19]
摘要: Over the last few years microalgae have gained increasing interest as a natural source of valuable compounds and as bioreactors for recombinant protein production. Natural high-value compounds including pigments, long-chain polyunsaturated fatty acids, and polysaccharides, which have a wide range of applications in the food, feed, cosmetics, and pharmaceutical industries, are currently produced with nontransgenic microalgae. However, transgenic microalgae can be used as bioreactors for the production of therapeutic and industrially relevant recombinant proteins. This technology shows great promise to simplify the production process and signiWcantly decrease the production costs. To date, a variety of recombinant proteins have been produced experimentally from the nuclear or chloroplast genome of transgenic Chlamydomonas reinhardtii. These include monoclonal antibodies, vaccines, hormones, pharmaceutical proteins, and others. In this review, we outline recent progress in the production of recombinant proteins with transgenic microalgae as bioreactors, methods for genetic transformation of microalgae, and strategies for highly efficient expression of heterologous genes. In particular, we highlight the importance of maximizing the value of transgenic microalgae through producing recombinant proteins together with recovery of natural high-value compounds. Finally, we outline some important issues that need to be addressed before commercial-scale production of high-value recombinant proteins and compounds from transgenic microalgae can be realized.
语种: 英语
ISSN号: 1367-5435
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/17061
Appears in Collections:藻类生物学及应用研究中心_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
Microalgae as platforms for production of recombinant proteins and valuable compounds_ progress and prospects.pdf(515KB)----开放获取--View Download

Recommended Citation:
Gong, Yangmin; Hu, Hanhua; Gao, Yuan; Xu, Xudong; Gao, Hong.Microalgae as platforms for production of recombinant proteins and valuable compounds: progress and prospects,JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY,2011,38(12):1879-1890
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Gong, Yangmin]'s Articles
[Hu, Hanhua]'s Articles
[Gao, Yuan]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Gong, Yangmin]‘s Articles
[Hu, Hanhua]‘s Articles
[Gao, Yuan]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Microalgae as platforms for production of recombinant proteins and valuable compounds_ progress and prospects.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2016  中国科学院水生生物研究所 - Feedback
Powered by CSpace