IHB OpenIR  > 水生生物分子与细胞生物学研究中心  > 期刊论文
Lzts2 Regulates Embryonic Cell Movements and Dorsoventral Patterning through Interaction with and Export of Nuclear beta-Catenin in Zebrafish
Li, Yuanyuan; Li, Qing; Long, Yong; Cui, Zongbin; Cui, ZB (reprint author), Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Hubei, Peoples R China.
2011
Source PublicationJOURNAL OF BIOLOGICAL CHEMISTRY
ISSN0021-9258
Volume286Issue:52Pages:45116-45130
AbstractLeucine zipper tumor suppressor 2 (Lzts2) functions in the development and progression of various tumors, but its activities in vertebrate embryogenesis remain unclear. Here, we demonstrate that lzts2 transcripts are of maternal origin in zebrafish embryos. Activation of BMP signaling up-regulates zygotic expression of lzts2, whereas canonical Wnt signaling acts upstream of BMP signaling to inhibit lzts2 expression. Abrogation of lzts2 expression by its specific morpholino-enhanced gastrula convergence and extension (CE) movements, dorsalized early embryos, and inhibited specification of midline progenitors for pancreas, liver, and heart. In contrast, ectopic expression of lzts2 led to the delay of CE movements and midline convergence of organ progenitors and resulted in a certain ratio of ventralized embryos. Mechanistically, Lzts2 regulates the migration of embryonic cells and dorsoventral patterning through its limitation of Wnt/beta-catenin activity, because it physically interacts with beta-catenin-1 and -2 and transports them out of the nucleus. In addition, both beta-catenin-1 and -2 exhibit redundant functions in activation of Stat3 signaling and in induction of Wnt5/11 expression through inhibition of BMP signaling and stimulation of Cyclops and Squint expression. Thus, Lzts2 regulates gastrula CE movements, dorsoventral patterning, and midline convergence and specification of organ precursors through interaction with and the export of nuclear beta-catenins in zebrafish.
KeywordConvergent Extension Movements Axis Formation Vertebrate Gastrulation Transcription Factors Protrusive Activity Xenopus Embryos Acts Downstream Wnt Pathway Protein Gene
Department[Li, Yuanyuan; Li, Qing; Long, Yong; Cui, Zongbin] Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Hubei, Peoples R China; [Li, Yuanyuan; Long, Yong] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
Funding OrganizationNational Natural Science Foundation of China[31171390]; National Basic Research Program of China[2012CB944500] ; National Natural Science Foundation of China[31171390]; National Basic Research Program of China[2012CB944500] ; National Natural Science Foundation of China[31171390]; National Basic Research Program of China[2012CB944500] ; National Natural Science Foundation of China[31171390]; National Basic Research Program of China[2012CB944500]
Indexed BySCI
Language英语
WOS IDWOS:000298645500078
Funding OrganizationNational Natural Science Foundation of China[31171390]; National Basic Research Program of China[2012CB944500] ; National Natural Science Foundation of China[31171390]; National Basic Research Program of China[2012CB944500] ; National Natural Science Foundation of China[31171390]; National Basic Research Program of China[2012CB944500] ; National Natural Science Foundation of China[31171390]; National Basic Research Program of China[2012CB944500]
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Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/17029
Collection水生生物分子与细胞生物学研究中心_期刊论文
Corresponding AuthorCui, ZB (reprint author), Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Hubei, Peoples R China.
Recommended Citation
GB/T 7714
Li, Yuanyuan,Li, Qing,Long, Yong,et al. Lzts2 Regulates Embryonic Cell Movements and Dorsoventral Patterning through Interaction with and Export of Nuclear beta-Catenin in Zebrafish[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2011,286(52):45116-45130.
APA Li, Yuanyuan,Li, Qing,Long, Yong,Cui, Zongbin,&Cui, ZB .(2011).Lzts2 Regulates Embryonic Cell Movements and Dorsoventral Patterning through Interaction with and Export of Nuclear beta-Catenin in Zebrafish.JOURNAL OF BIOLOGICAL CHEMISTRY,286(52),45116-45130.
MLA Li, Yuanyuan,et al."Lzts2 Regulates Embryonic Cell Movements and Dorsoventral Patterning through Interaction with and Export of Nuclear beta-Catenin in Zebrafish".JOURNAL OF BIOLOGICAL CHEMISTRY 286.52(2011):45116-45130.
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