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题名: Role of Zebrafish Lbx2 in Embryonic Lateral Line Development
作者: Chen, Xiaowen ; Lou, Qiyong ; He, Jiangyan ; Yin, Zhan
通讯作者: Chen, XW (reprint author), Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan, Hubei, Peoples R China.
关键词: TRANSCRIPTION FACTOR LBX1 ; MUSCLE PRECURSOR CELLS ; DORSAL SPINAL-CORD ; GENE LBX1 ; TRANSMITTER PHENOTYPES ; TISSUE MIGRATION ; DANIO-RERIO ; HAIR-CELLS ; IN-VIVO ; EXPRESSION
刊名: PLOS ONE
发表日期: 2011
卷: 6, 期:12, 页:e29515
收录类别: SCI
部门归属: [Chen, Xiaowen; Lou, Qiyong; He, Jiangyan; Yin, Zhan] Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan, Hubei, Peoples R China; [Chen, Xiaowen; Lou, Qiyong; He, Jiangyan; Yin, Zhan] Chinese Acad Sci, Grad Univ, Beijing, Peoples R China
资助者: National Basic Research Program[2009CB118701, 2010CB126302]; Chinese Natural Science Foundation[30871402, 30925027]
摘要: Background: The zebrafish ladybird homeobox homologous gene 2 (lbx2) has been suggested to play a key role in the regulation of hypaxial myogenic precursor cell migration. Unlike their lbx counterparts in mammals, the function of teleost lbx genes beyond myogenesis during embryonic development remains unexplored. Principal Findings: Abrogation of lbx2 function using a specific independent morpholino oligonucleotide (MO) or truncated lbx2 mRNA with an engrailed domain deletion (lbx2(eh-)) resulted in defective formation of the zebrafish posterior lateral line (PLL). Migration of the PLL primordium was altered and accompanied by increased cell death in the primordium of lbx2-MO-injected embryos. A decreased number of muscle pioneer cells and impaired expression pattern of sdf1a in the horizontal myoseptum was observed in lbx2 morphants. Significance: Injection of lbx2 MO or lbx2(eh-) mRNA resulted in defective PPL formation and altered sdf1a expression, confirming an important function for lbx2 in sdf1a-dependent migration. In addition, the disassociation of PPL nerve extension with PLL primordial migration in some lbx2 morphants suggests that pathfinding of the PLL primordium and the lateral line nerve may be regulated independently.
语种: 英语
WOS记录号: WOS:000299684700063
ISSN号: 1932-6203
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/17025
Appears in Collections:水生生物分子与细胞生物学研究中心_期刊论文

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Recommended Citation:
Chen, Xiaowen; Lou, Qiyong; He, Jiangyan; Yin, Zhan.Role of Zebrafish Lbx2 in Embryonic Lateral Line Development,PLOS ONE,2011,6(12):e29515
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