IHB OpenIR  > 水生生物分子与细胞生物学研究中心  > 期刊论文
Role of Zebrafish Lbx2 in Embryonic Lateral Line Development
Chen, Xiaowen; Lou, Qiyong; He, Jiangyan; Yin, Zhan; Chen, XW (reprint author), Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan, Hubei, Peoples R China.
2011
Source PublicationPLOS ONE
ISSN1932-6203
Volume6Issue:12Pages:e29515
AbstractBackground: The zebrafish ladybird homeobox homologous gene 2 (lbx2) has been suggested to play a key role in the regulation of hypaxial myogenic precursor cell migration. Unlike their lbx counterparts in mammals, the function of teleost lbx genes beyond myogenesis during embryonic development remains unexplored. Principal Findings: Abrogation of lbx2 function using a specific independent morpholino oligonucleotide (MO) or truncated lbx2 mRNA with an engrailed domain deletion (lbx2(eh-)) resulted in defective formation of the zebrafish posterior lateral line (PLL). Migration of the PLL primordium was altered and accompanied by increased cell death in the primordium of lbx2-MO-injected embryos. A decreased number of muscle pioneer cells and impaired expression pattern of sdf1a in the horizontal myoseptum was observed in lbx2 morphants. Significance: Injection of lbx2 MO or lbx2(eh-) mRNA resulted in defective PPL formation and altered sdf1a expression, confirming an important function for lbx2 in sdf1a-dependent migration. In addition, the disassociation of PPL nerve extension with PLL primordial migration in some lbx2 morphants suggests that pathfinding of the PLL primordium and the lateral line nerve may be regulated independently.
KeywordTranscription Factor Lbx1 Muscle Precursor Cells Dorsal Spinal-cord Gene Lbx1 Transmitter Phenotypes Tissue Migration Danio-rerio Hair-cells In-vivo Expression
Department[Chen, Xiaowen; Lou, Qiyong; He, Jiangyan; Yin, Zhan] Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan, Hubei, Peoples R China; [Chen, Xiaowen; Lou, Qiyong; He, Jiangyan; Yin, Zhan] Chinese Acad Sci, Grad Univ, Beijing, Peoples R China
Funding OrganizationNational Basic Research Program[2009CB118701, 2010CB126302]; Chinese Natural Science Foundation[30871402, 30925027] ; National Basic Research Program[2009CB118701, 2010CB126302]; Chinese Natural Science Foundation[30871402, 30925027] ; National Basic Research Program[2009CB118701, 2010CB126302]; Chinese Natural Science Foundation[30871402, 30925027] ; National Basic Research Program[2009CB118701, 2010CB126302]; Chinese Natural Science Foundation[30871402, 30925027]
Indexed BySCI
Language英语
WOS IDWOS:000299684700063
Funding OrganizationNational Basic Research Program[2009CB118701, 2010CB126302]; Chinese Natural Science Foundation[30871402, 30925027] ; National Basic Research Program[2009CB118701, 2010CB126302]; Chinese Natural Science Foundation[30871402, 30925027] ; National Basic Research Program[2009CB118701, 2010CB126302]; Chinese Natural Science Foundation[30871402, 30925027] ; National Basic Research Program[2009CB118701, 2010CB126302]; Chinese Natural Science Foundation[30871402, 30925027]
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/17025
Collection水生生物分子与细胞生物学研究中心_期刊论文
Corresponding AuthorChen, XW (reprint author), Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan, Hubei, Peoples R China.
Recommended Citation
GB/T 7714
Chen, Xiaowen,Lou, Qiyong,He, Jiangyan,et al. Role of Zebrafish Lbx2 in Embryonic Lateral Line Development[J]. PLOS ONE,2011,6(12):e29515.
APA Chen, Xiaowen,Lou, Qiyong,He, Jiangyan,Yin, Zhan,&Chen, XW .(2011).Role of Zebrafish Lbx2 in Embryonic Lateral Line Development.PLOS ONE,6(12),e29515.
MLA Chen, Xiaowen,et al."Role of Zebrafish Lbx2 in Embryonic Lateral Line Development".PLOS ONE 6.12(2011):e29515.
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