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Parental Transfer of Polybrominated Diphenyl Ethers (PBDEs) and Thyroid Endocrine Disruption in Zebrafish
Yu, Liqin; Lam, James C. W.; Guo, Yongyong; Wu, Rudolf S. S.; Lam, Paul K. S.; Zhou, Bingsheng; Lam, PKS (reprint author), City Univ Hong Kong, State Key Lab Marine Pollut, Dept Biol & Chem, Hong Kong, Hong Kong, Peoples R China.
2011
Source PublicationENVIRONMENTAL SCIENCE & TECHNOLOGY
ISSN0013-936X
Volume45Issue:24Pages:10652-10659
AbstractPolybrominated diphenyl ethers (PBDEs) have the potential to disrupt the thyroid endocrine system. The objective of the present study was to characterize the disrupting effects of long-term exposure on the thyroid endocrine system in adult fish and their progeny following parental exposure to PBDEs. Zebrafish (Danio rerio) embryos were exposed to environmentally relevant concentrations (1, 3, and 10 mu g/L) of the PBDE mixture DE-71 for 5 months until sexual maturation. In the F0 generation, exposure to DE-71 significantly increased plasma thyroxine (T4) but not 3,5,3'-triiodothyronine (T3) in females. This increased T4 was accompanied by decreased mRNA levels of corticotropin-releasing hormone (CRH) and thyrotropin beta-subunit (TSH beta) in the brain. The F1 generation was further examined with or without continued DE-71 treatment conditions. Exposure to DE-71 in the F0 fish caused significant increases in T4 and T3 levels in the F1 larvae and modified gene expressions in the hypothalamic-pituitary-thyroid axis (HPT axis) under both conditions. Decreased hatching and inhibition of growth in the F1 offspring were observed in the condition without DE-71 treatment. Continued DE-71 treatment in the F1 embryos/larvae resulted in further decreased hatching, and increased malformation rates compared with those without DE-71 exposure. Analysis of F1 eggs indicated that parental exposure to DE-71 could result in a transfer of PBDEs and thyroid hormones (THs) to their offspring. For the first time, we demonstrated that parental exposure to low concentrations of PBDEs could affect THs in the offspring and the transgenerational PBDE-induced toxicity in subsequent nonexposed generations.
KeywordBrominated Flame Retardants Polychlorinated-biphenyls Pcbs Developmental Exposure Maternal Transfer Hormone Levels Danio-rerio Embryonic-development Gene-expression De-71 Mixture
Department[Lam, James C. W.; Lam, Paul K. S.] City Univ Hong Kong, State Key Lab Marine Pollut, Dept Biol & Chem, Hong Kong, Hong Kong, Peoples R China; [Yu, Liqin; Guo, Yongyong; Zhou, Bingsheng] Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan 430072, Peoples R China; [Wu, Rudolf S. S.] Univ Hong Kong, Sch Biol Sci, Hong Kong, Hong Kong, Peoples R China
Funding OrganizationNSFC[20890113]; Chinese Academy of Sciences[KCZCX2-YW-Q02-05]; FEBL[2008FBZ10] ; NSFC[20890113]; Chinese Academy of Sciences[KCZCX2-YW-Q02-05]; FEBL[2008FBZ10] ; NSFC[20890113]; Chinese Academy of Sciences[KCZCX2-YW-Q02-05]; FEBL[2008FBZ10] ; NSFC[20890113]; Chinese Academy of Sciences[KCZCX2-YW-Q02-05]; FEBL[2008FBZ10]
Indexed BySCI
Language英语
WOS IDWOS:000298118300054
Funding OrganizationNSFC[20890113]; Chinese Academy of Sciences[KCZCX2-YW-Q02-05]; FEBL[2008FBZ10] ; NSFC[20890113]; Chinese Academy of Sciences[KCZCX2-YW-Q02-05]; FEBL[2008FBZ10] ; NSFC[20890113]; Chinese Academy of Sciences[KCZCX2-YW-Q02-05]; FEBL[2008FBZ10] ; NSFC[20890113]; Chinese Academy of Sciences[KCZCX2-YW-Q02-05]; FEBL[2008FBZ10]
Citation statistics
Cited Times:105[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/17005
Collection水环境工程研究中心_期刊论文
Corresponding AuthorLam, PKS (reprint author), City Univ Hong Kong, State Key Lab Marine Pollut, Dept Biol & Chem, Hong Kong, Hong Kong, Peoples R China.
Recommended Citation
GB/T 7714
Yu, Liqin,Lam, James C. W.,Guo, Yongyong,et al. Parental Transfer of Polybrominated Diphenyl Ethers (PBDEs) and Thyroid Endocrine Disruption in Zebrafish[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2011,45(24):10652-10659.
APA Yu, Liqin.,Lam, James C. W..,Guo, Yongyong.,Wu, Rudolf S. S..,Lam, Paul K. S..,...&Lam, PKS .(2011).Parental Transfer of Polybrominated Diphenyl Ethers (PBDEs) and Thyroid Endocrine Disruption in Zebrafish.ENVIRONMENTAL SCIENCE & TECHNOLOGY,45(24),10652-10659.
MLA Yu, Liqin,et al."Parental Transfer of Polybrominated Diphenyl Ethers (PBDEs) and Thyroid Endocrine Disruption in Zebrafish".ENVIRONMENTAL SCIENCE & TECHNOLOGY 45.24(2011):10652-10659.
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