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题名: Parental Transfer of Polybrominated Diphenyl Ethers (PBDEs) and Thyroid Endocrine Disruption in Zebrafish
作者: Yu, Liqin ; Lam, James C. W. ; Guo, Yongyong ; Wu, Rudolf S. S. ; Lam, Paul K. S. ; Zhou, Bingsheng
通讯作者: Lam, PKS (reprint author), City Univ Hong Kong, State Key Lab Marine Pollut, Dept Biol & Chem, Hong Kong, Hong Kong, Peoples R China.
关键词: BROMINATED FLAME RETARDANTS ; POLYCHLORINATED-BIPHENYLS PCBS ; DEVELOPMENTAL EXPOSURE ; MATERNAL TRANSFER ; HORMONE LEVELS ; DANIO-RERIO ; EMBRYONIC-DEVELOPMENT ; GENE-EXPRESSION ; DE-71 ; MIXTURE
刊名: ENVIRONMENTAL SCIENCE & TECHNOLOGY
发表日期: 2011
卷: 45, 期:24, 页:10652-10659
收录类别: SCI
部门归属: [Lam, James C. W.; Lam, Paul K. S.] City Univ Hong Kong, State Key Lab Marine Pollut, Dept Biol & Chem, Hong Kong, Hong Kong, Peoples R China; [Yu, Liqin; Guo, Yongyong; Zhou, Bingsheng] Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan 430072, Peoples R China; [Wu, Rudolf S. S.] Univ Hong Kong, Sch Biol Sci, Hong Kong, Hong Kong, Peoples R China
资助者: NSFC[20890113]; Chinese Academy of Sciences[KCZCX2-YW-Q02-05]; FEBL[2008FBZ10]
摘要: Polybrominated diphenyl ethers (PBDEs) have the potential to disrupt the thyroid endocrine system. The objective of the present study was to characterize the disrupting effects of long-term exposure on the thyroid endocrine system in adult fish and their progeny following parental exposure to PBDEs. Zebrafish (Danio rerio) embryos were exposed to environmentally relevant concentrations (1, 3, and 10 mu g/L) of the PBDE mixture DE-71 for 5 months until sexual maturation. In the F0 generation, exposure to DE-71 significantly increased plasma thyroxine (T4) but not 3,5,3'-triiodothyronine (T3) in females. This increased T4 was accompanied by decreased mRNA levels of corticotropin-releasing hormone (CRH) and thyrotropin beta-subunit (TSH beta) in the brain. The F1 generation was further examined with or without continued DE-71 treatment conditions. Exposure to DE-71 in the F0 fish caused significant increases in T4 and T3 levels in the F1 larvae and modified gene expressions in the hypothalamic-pituitary-thyroid axis (HPT axis) under both conditions. Decreased hatching and inhibition of growth in the F1 offspring were observed in the condition without DE-71 treatment. Continued DE-71 treatment in the F1 embryos/larvae resulted in further decreased hatching, and increased malformation rates compared with those without DE-71 exposure. Analysis of F1 eggs indicated that parental exposure to DE-71 could result in a transfer of PBDEs and thyroid hormones (THs) to their offspring. For the first time, we demonstrated that parental exposure to low concentrations of PBDEs could affect THs in the offspring and the transgenerational PBDE-induced toxicity in subsequent nonexposed generations.
语种: 英语
WOS记录号: WOS:000298118300054
ISSN号: 0013-936X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/17005
Appears in Collections:水环境工程研究中心_期刊论文

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Recommended Citation:
Yu, Liqin; Lam, James C. W.; Guo, Yongyong; Wu, Rudolf S. S.; Lam, Paul K. S.; Zhou, Bingsheng.Parental Transfer of Polybrominated Diphenyl Ethers (PBDEs) and Thyroid Endocrine Disruption in Zebrafish,ENVIRONMENTAL SCIENCE & TECHNOLOGY,2011,45(24):10652-10659
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