IHB OpenIR  > 鱼类生物学及渔业生物技术研究中心  > 期刊论文
IDENTIFICATION AND CHARACTERIZATION OF A MITOCHONDRIAL MANGANESE SUPEROXIDE DISMUTASE OF SPIROMETRA ERINACEI
Li, Ai-Hua; Na, Byoung-Kuk; Song, Kyoung-Ju; Lim, Sung-Bin; Chong, Chom-Kyu; Park, Yun-Kyu; Kim, Tong-Soo; Kim, TS (reprint author), Inha Univ, Sch Med, Dept Parasitol, Inchon 400712, South Korea.
2011
Source PublicationJOURNAL OF PARASITOLOGY
ISSN0022-3395
Volume97Issue:6Pages:1106-1112
AbstractA gene encoding the manganese superoxide dismutase (Mn-SOD) of Spirometra erinacei was identified, and the biochemical properties of the recombinant enzyme were partially characterized. The S. erinacei Mn-SOD gene consisted of 669 bp, which encoded 222 amino acids. A sequence analysis of the gene showed that it had typical molecular structures, including characteristic metal-binding residues and motifs that were conserved in Mn-SODs. An analysis of the N-terminal presequence of S. erinacei Mn-SOD revealed that it had physiochemical characteristics commonly found in mitochondria-targeting sequences and predicted that the enzyme is located in the mitochondria. A biochemical analysis also revealed that the enzyme is a typical Mn-SOD. The enzyme was consistently expressed in both S. erinacei plerocercoid larvae and adult worms. Our results collectively suggested that S. erinacei Mn-SOD is a typical mitochondrial Mn-SOD and may play an important role in parasite physiology, detoxifying excess superoxide radicals generated in the mitochondria.
KeywordParasite Onchocerca-volvulus Schistosoma-mansoni Molecular-cloning Escherichia-coli Trichinella-pseudospiralis Fasciola-hepatica Filarial Nematode Oxidative Stress Taenia-solium Iron
Department[Li, Ai-Hua; Na, Byoung-Kuk; Song, Kyoung-Ju; Lim, Sung-Bin; Chong, Chom-Kyu; Park, Yun-Kyu; Kim, Tong-Soo] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
Funding OrganizationInha University ; Inha University ; Inha University ; Inha University
Indexed BySCI
Language英语
WOS IDWOS:000299022100023
Funding OrganizationInha University ; Inha University ; Inha University ; Inha University
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Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/16959
Collection鱼类生物学及渔业生物技术研究中心_期刊论文
Corresponding AuthorKim, TS (reprint author), Inha Univ, Sch Med, Dept Parasitol, Inchon 400712, South Korea.
Recommended Citation
GB/T 7714
Li, Ai-Hua,Na, Byoung-Kuk,Song, Kyoung-Ju,et al. IDENTIFICATION AND CHARACTERIZATION OF A MITOCHONDRIAL MANGANESE SUPEROXIDE DISMUTASE OF SPIROMETRA ERINACEI[J]. JOURNAL OF PARASITOLOGY,2011,97(6):1106-1112.
APA Li, Ai-Hua.,Na, Byoung-Kuk.,Song, Kyoung-Ju.,Lim, Sung-Bin.,Chong, Chom-Kyu.,...&Kim, TS .(2011).IDENTIFICATION AND CHARACTERIZATION OF A MITOCHONDRIAL MANGANESE SUPEROXIDE DISMUTASE OF SPIROMETRA ERINACEI.JOURNAL OF PARASITOLOGY,97(6),1106-1112.
MLA Li, Ai-Hua,et al."IDENTIFICATION AND CHARACTERIZATION OF A MITOCHONDRIAL MANGANESE SUPEROXIDE DISMUTASE OF SPIROMETRA ERINACEI".JOURNAL OF PARASITOLOGY 97.6(2011):1106-1112.
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