IHB OpenIR  > 鱼类生物学及渔业生物技术研究中心  > 期刊论文
Diversification of Schistosoma japonicum in Mainland China Revealed by Mitochondrial DNA
Zhao, Qin Ping1,2; Sen Jiang, Ming1; Dong, Hui Fen1; Nie, Pin2; Zhao, QP (reprint author), Wuhan Univ, Dept Parasitol, Sch Basic Med, Wuhan 430072, Hubei Province, Peoples R China.
2012-02-01
Source PublicationPLOS NEGLECTED TROPICAL DISEASES
ISSN1935-2727
Volume6Issue:2Pages:e1503
AbstractBackground: Schistosoma japonicum still causes severe parasitic disease in mainland China, but mainly in areas along the Yangtze River. However, the genetic diversity in populations of S. japonicum has not been well understood across its geographical distribution, and such data may provide insights into the epidemiology and possible control strategies for schistosomiasis. Methodology/Principal Findings: In this study infected Oncomelania snails were collected from areas in the middle and lower (ML) reaches of the Yangtze River, including Hubei, Hunan, Anhui, Jiangxi and Jiangsu provinces, and in the upper reaches of the river, including Sichuan and Yunnan provinces in southwest (SW) China. The adult parasites obtained from experimentally infected mice using isolated cercariae were sequenced individually for several fragments of mitochondrial regions, including Cytb-ND4L-ND4, 16S-12S and ND1. Populations in the ML reaches exhibited a relatively high level of diversity in nucleotides and haplotypes, whereas a low level was observed for populations in the SW, using either each single fragment or the combined sequence of the three fragments. Pairwise analyses of F-statistics (Fst) revealed a significant genetic difference between populations in the ML reaches and those in the SW, with limited gene flow and no shared haplotypes in between. It is rather obvious that genetic diversity in the populations of S. japonicum was significantly correlated with the geographical distance, and the geographical separation/isolation was considered to be the major factor accounting for the observed difference between populations in the ML reaches and those in the SW in China. Conclusions: S. japonicum in mainland China exhibits a high degree of genetic diversity, with a similar pattern of genetic diversity as observed in the intermediate host snails in the same region in China.; Background: Schistosoma japonicum still causes severe parasitic disease in mainland China, but mainly in areas along the Yangtze River. However, the genetic diversity in populations of S. japonicum has not been well understood across its geographical distribution, and such data may provide insights into the epidemiology and possible control strategies for schistosomiasis.
SubtypeArticle
KeywordOncomelania-hupensis Gastropoda Population Genetic-structure Molecular Phylogeny Sequence Alignment Ecology Host Polymorphism Pomatiopsidae Epidemiology Diversity
Department[Zhao, Qin Ping; Sen Jiang, Ming; Dong, Hui Fen] Wuhan Univ, Dept Parasitol, Sch Basic Med, Wuhan 430072, Hubei Province, Peoples R China; [Zhao, Qin Ping; Nie, Pin] Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan, Hubei Province, Peoples R China
DOI10.1371/journal.pntd.0001503
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Funding OrganizationNational Natural Science Foundation[30770353]; Chinese Academy of Science[KSCX2-YW-N-055, KSCX2-YW-2-0808] ; National Natural Science Foundation[30770353]; Chinese Academy of Science[KSCX2-YW-N-055, KSCX2-YW-2-0808] ; National Natural Science Foundation[30770353]; Chinese Academy of Science[KSCX2-YW-N-055, KSCX2-YW-2-0808] ; National Natural Science Foundation[30770353]; Chinese Academy of Science[KSCX2-YW-N-055, KSCX2-YW-2-0808]
Indexed BySCI
Language英语
WOS Research AreaInfectious Diseases ; Parasitology ; Tropical Medicine
WOS SubjectInfectious Diseases ; Parasitology ; Tropical Medicine
WOS IDWOS:000300949200017
WOS KeywordONCOMELANIA-HUPENSIS GASTROPODA ; POPULATION GENETIC-STRUCTURE ; MOLECULAR PHYLOGENY ; SEQUENCE ALIGNMENT ; ECOLOGY ; HOST ; POLYMORPHISM ; POMATIOPSIDAE ; EPIDEMIOLOGY ; DIVERSITY
Funding OrganizationNational Natural Science Foundation[30770353]; Chinese Academy of Science[KSCX2-YW-N-055, KSCX2-YW-2-0808] ; National Natural Science Foundation[30770353]; Chinese Academy of Science[KSCX2-YW-N-055, KSCX2-YW-2-0808] ; National Natural Science Foundation[30770353]; Chinese Academy of Science[KSCX2-YW-N-055, KSCX2-YW-2-0808] ; National Natural Science Foundation[30770353]; Chinese Academy of Science[KSCX2-YW-N-055, KSCX2-YW-2-0808]
Citation statistics
Cited Times:21[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/16951
Collection鱼类生物学及渔业生物技术研究中心_期刊论文
Corresponding AuthorZhao, QP (reprint author), Wuhan Univ, Dept Parasitol, Sch Basic Med, Wuhan 430072, Hubei Province, Peoples R China.
Affiliation1.Wuhan Univ, Dept Parasitol, Sch Basic Med, Wuhan 430072, Hubei Province, Peoples R China
2.Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan, Hubei Province, Peoples R China
Recommended Citation
GB/T 7714
Zhao, Qin Ping,Sen Jiang, Ming,Dong, Hui Fen,et al. Diversification of Schistosoma japonicum in Mainland China Revealed by Mitochondrial DNA[J]. PLOS NEGLECTED TROPICAL DISEASES,2012,6(2):e1503.
APA Zhao, Qin Ping,Sen Jiang, Ming,Dong, Hui Fen,Nie, Pin,&Zhao, QP .(2012).Diversification of Schistosoma japonicum in Mainland China Revealed by Mitochondrial DNA.PLOS NEGLECTED TROPICAL DISEASES,6(2),e1503.
MLA Zhao, Qin Ping,et al."Diversification of Schistosoma japonicum in Mainland China Revealed by Mitochondrial DNA".PLOS NEGLECTED TROPICAL DISEASES 6.2(2012):e1503.
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