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题名: Diversification of Schistosoma japonicum in Mainland China Revealed by Mitochondrial DNA
作者: Zhao, Qin Ping1, 2; Sen Jiang, Ming1; Dong, Hui Fen1; Nie, Pin2
通讯作者: Zhao, QP (reprint author), Wuhan Univ, Dept Parasitol, Sch Basic Med, Wuhan 430072, Hubei Province, Peoples R China.
关键词: ONCOMELANIA-HUPENSIS GASTROPODA ; POPULATION GENETIC-STRUCTURE ; MOLECULAR PHYLOGENY ; SEQUENCE ALIGNMENT ; ECOLOGY ; HOST ; POLYMORPHISM ; POMATIOPSIDAE ; EPIDEMIOLOGY ; DIVERSITY
刊名: PLOS NEGLECTED TROPICAL DISEASES
发表日期: 2012-02-01
DOI: 10.1371/journal.pntd.0001503
卷: 6, 期:2, 页:e1503
收录类别: SCI
文章类型: Article
部门归属: [Zhao, Qin Ping; Sen Jiang, Ming; Dong, Hui Fen] Wuhan Univ, Dept Parasitol, Sch Basic Med, Wuhan 430072, Hubei Province, Peoples R China; [Zhao, Qin Ping; Nie, Pin] Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan, Hubei Province, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
资助者: National Natural Science Foundation[30770353]; Chinese Academy of Science[KSCX2-YW-N-055, KSCX2-YW-2-0808]
类目[WOS]: Infectious Diseases ; Parasitology ; Tropical Medicine
研究领域[WOS]: Infectious Diseases ; Parasitology ; Tropical Medicine
摘要: Background: Schistosoma japonicum still causes severe parasitic disease in mainland China, but mainly in areas along the Yangtze River. However, the genetic diversity in populations of S. japonicum has not been well understood across its geographical distribution, and such data may provide insights into the epidemiology and possible control strategies for schistosomiasis. Methodology/Principal Findings: In this study infected Oncomelania snails were collected from areas in the middle and lower (ML) reaches of the Yangtze River, including Hubei, Hunan, Anhui, Jiangxi and Jiangsu provinces, and in the upper reaches of the river, including Sichuan and Yunnan provinces in southwest (SW) China. The adult parasites obtained from experimentally infected mice using isolated cercariae were sequenced individually for several fragments of mitochondrial regions, including Cytb-ND4L-ND4, 16S-12S and ND1. Populations in the ML reaches exhibited a relatively high level of diversity in nucleotides and haplotypes, whereas a low level was observed for populations in the SW, using either each single fragment or the combined sequence of the three fragments. Pairwise analyses of F-statistics (Fst) revealed a significant genetic difference between populations in the ML reaches and those in the SW, with limited gene flow and no shared haplotypes in between. It is rather obvious that genetic diversity in the populations of S. japonicum was significantly correlated with the geographical distance, and the geographical separation/isolation was considered to be the major factor accounting for the observed difference between populations in the ML reaches and those in the SW in China. Conclusions: S. japonicum in mainland China exhibits a high degree of genetic diversity, with a similar pattern of genetic diversity as observed in the intermediate host snails in the same region in China.
英文摘要: Background: Schistosoma japonicum still causes severe parasitic disease in mainland China, but mainly in areas along the Yangtze River. However, the genetic diversity in populations of S. japonicum has not been well understood across its geographical distribution, and such data may provide insights into the epidemiology and possible control strategies for schistosomiasis.
关键词[WOS]: ONCOMELANIA-HUPENSIS GASTROPODA ; POPULATION GENETIC-STRUCTURE ; MOLECULAR PHYLOGENY ; SEQUENCE ALIGNMENT ; ECOLOGY ; HOST ; POLYMORPHISM ; POMATIOPSIDAE ; EPIDEMIOLOGY ; DIVERSITY
语种: 英语
WOS记录号: WOS:000300949200017
ISSN号: 1935-2727
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/16951
Appears in Collections:鱼类生物学及渔业生物技术研究中心_期刊论文

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作者单位: 1.Wuhan Univ, Dept Parasitol, Sch Basic Med, Wuhan 430072, Hubei Province, Peoples R China
2.Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan, Hubei Province, Peoples R China

Recommended Citation:
Zhao, Qin Ping; Sen Jiang, Ming; Dong, Hui Fen; Nie, Pin.Diversification of Schistosoma japonicum in Mainland China Revealed by Mitochondrial DNA,PLOS NEGLECTED TROPICAL DISEASES,2012,6(2):e1503
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