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Nephrotoxic effects from chronic toxic cyanobacterial blooms in fishes with different trophic levels in a large Chinese lake
Qiu, Tong1,2; Xie, Ping1; Li, Li3; Guo, Longgen1; Zhang, Dawen1; Zhou, Qiong1; Xie, P (reprint author), Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China.
2012-03-01
Source PublicationENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
ISSN1382-6689
Volume33Issue:2Pages:252-261
AbstractPhysiological and biochemical responses in kidneys of fishes with different trophic levels to toxic cyanobacterial blooms were studied. We sampled four fishes: the phytoplanktivorous Hypophthalmichthys molitrix and Aristichthys nobilis, the omnivorous Carassius auratus, and the carnivorous Culter ilishaeformis. Alterations of the antioxidant (GSH) and the major antioxidant enzymes (CAT, SOD, GPx, GST) were monitored monthly. Catalase and glutathione S-transferase were significantly higher during blooms than before and after blooms. All fishes showed ultrastructural alterations during blooms, which mainly are inosculation of foot processes in epithelial cell of glomeruli and mitochondria swelling in the proximal tubules. The results suggested that kidney impairment from chronic exposure of toxic cyanobacterial blooms might be the first step, and then followed by hepatic failure. Compared with livers in terms of physiological status, the weaker antioxidant ability of kidney made it more susceptible to chronic MCs exposure, besides its effective accumulation of MC metabolites. (C) 2011 Elsevier B.V. All rights reserved.; Physiological and biochemical responses in kidneys of fishes with different trophic levels to toxic cyanobacterial blooms were studied. We sampled four fishes: the phytoplanktivorous Hypophthalmichthys molitrix and Aristichthys nobilis, the omnivorous Carassius auratus, and the carnivorous Culter ilishaeformis. Alterations of the antioxidant (GSH) and the major antioxidant enzymes (CAT, SOD, GPx, GST) were monitored monthly. Catalase and glutathione S-transferase were significantly higher during blooms than before and after blooms. All fishes showed ultrastructural alterations during blooms, which mainly are inosculation of foot processes in epithelial cell of glomeruli and mitochondria swelling in the proximal tubules. The results suggested that kidney impairment from chronic exposure of toxic cyanobacterial blooms might be the first step, and then followed by hepatic failure. Compared with livers in terms of physiological status, the weaker antioxidant ability of kidney made it more susceptible to chronic MCs exposure, besides its effective accumulation of MC metabolites. (C) 2011 Elsevier B.V. All rights reserved.
SubtypeArticle
KeywordToxic Cyanobacterial Blooms Fish Trophic Level Kidney Antioxidants System Ultrastructure
Department[Qiu, Tong; Xie, Ping; Guo, Longgen; Zhang, Dawen; Zhou, Qiong] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China; [Qiu, Tong] Wuhan Univ Technol, Biomed Mat & Engn Ctr, Wuhan 430070, Peoples R China; [Li, Li] Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Peoples R China
DOI10.1016/j.etap.2011.12.004
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Funding OrganizationNational Natural Science Foundation of China[30530170] ; National Natural Science Foundation of China[30530170] ; National Natural Science Foundation of China[30530170] ; National Natural Science Foundation of China[30530170]
Indexed BySCI
Language英语
WOS Research AreaEnvironmental Sciences & Ecology ; Pharmacology & Pharmacy ; Toxicology
WOS SubjectEnvironmental Sciences ; Pharmacology & Pharmacy ; Toxicology
WOS IDWOS:000301475000016
WOS KeywordFRESH-WATER FISH ; OXIDATIVE STRESS ; IN-SITU ; BIOCHEMICAL RESPONSES ; MICROCYSTIS BLOOMS ; OREOCHROMIS SP. ; LR ; BIOACCUMULATION ; HEPATOPANCREAS ; HEPATOTOXINS
Funding OrganizationNational Natural Science Foundation of China[30530170] ; National Natural Science Foundation of China[30530170] ; National Natural Science Foundation of China[30530170] ; National Natural Science Foundation of China[30530170]
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/16885
Collection淡水生态学研究中心_期刊论文
Corresponding AuthorXie, P (reprint author), Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China.
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China
2.Wuhan Univ Technol, Biomed Mat & Engn Ctr, Wuhan 430070, Peoples R China
3.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Peoples R China
Recommended Citation
GB/T 7714
Qiu, Tong,Xie, Ping,Li, Li,et al. Nephrotoxic effects from chronic toxic cyanobacterial blooms in fishes with different trophic levels in a large Chinese lake[J]. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2012,33(2):252-261.
APA Qiu, Tong.,Xie, Ping.,Li, Li.,Guo, Longgen.,Zhang, Dawen.,...&Xie, P .(2012).Nephrotoxic effects from chronic toxic cyanobacterial blooms in fishes with different trophic levels in a large Chinese lake.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,33(2),252-261.
MLA Qiu, Tong,et al."Nephrotoxic effects from chronic toxic cyanobacterial blooms in fishes with different trophic levels in a large Chinese lake".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 33.2(2012):252-261.
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