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题名: Nephrotoxic effects from chronic toxic cyanobacterial blooms in fishes with different trophic levels in a large Chinese lake
作者: Qiu, Tong1, 2; Xie, Ping1; Li, Li3; Guo, Longgen1; Zhang, Dawen1; Zhou, Qiong1
通讯作者: Xie, P (reprint author), Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China.
关键词: Toxic cyanobacterial blooms ; Fish ; Trophic level ; Kidney ; Antioxidants system ; Ultrastructure
刊名: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
发表日期: 2012-03-01
DOI: 10.1016/j.etap.2011.12.004
卷: 33, 期:2, 页:252-261
收录类别: SCI
文章类型: Article
部门归属: [Qiu, Tong; Xie, Ping; Guo, Longgen; Zhang, Dawen; Zhou, Qiong] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China; [Qiu, Tong] Wuhan Univ Technol, Biomed Mat & Engn Ctr, Wuhan 430070, Peoples R China; [Li, Li] Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
资助者: National Natural Science Foundation of China[30530170]
类目[WOS]: Environmental Sciences ; Pharmacology & Pharmacy ; Toxicology
研究领域[WOS]: Environmental Sciences & Ecology ; Pharmacology & Pharmacy ; Toxicology
摘要: Physiological and biochemical responses in kidneys of fishes with different trophic levels to toxic cyanobacterial blooms were studied. We sampled four fishes: the phytoplanktivorous Hypophthalmichthys molitrix and Aristichthys nobilis, the omnivorous Carassius auratus, and the carnivorous Culter ilishaeformis. Alterations of the antioxidant (GSH) and the major antioxidant enzymes (CAT, SOD, GPx, GST) were monitored monthly. Catalase and glutathione S-transferase were significantly higher during blooms than before and after blooms. All fishes showed ultrastructural alterations during blooms, which mainly are inosculation of foot processes in epithelial cell of glomeruli and mitochondria swelling in the proximal tubules. The results suggested that kidney impairment from chronic exposure of toxic cyanobacterial blooms might be the first step, and then followed by hepatic failure. Compared with livers in terms of physiological status, the weaker antioxidant ability of kidney made it more susceptible to chronic MCs exposure, besides its effective accumulation of MC metabolites. (C) 2011 Elsevier B.V. All rights reserved.
英文摘要: Physiological and biochemical responses in kidneys of fishes with different trophic levels to toxic cyanobacterial blooms were studied. We sampled four fishes: the phytoplanktivorous Hypophthalmichthys molitrix and Aristichthys nobilis, the omnivorous Carassius auratus, and the carnivorous Culter ilishaeformis. Alterations of the antioxidant (GSH) and the major antioxidant enzymes (CAT, SOD, GPx, GST) were monitored monthly. Catalase and glutathione S-transferase were significantly higher during blooms than before and after blooms. All fishes showed ultrastructural alterations during blooms, which mainly are inosculation of foot processes in epithelial cell of glomeruli and mitochondria swelling in the proximal tubules. The results suggested that kidney impairment from chronic exposure of toxic cyanobacterial blooms might be the first step, and then followed by hepatic failure. Compared with livers in terms of physiological status, the weaker antioxidant ability of kidney made it more susceptible to chronic MCs exposure, besides its effective accumulation of MC metabolites. (C) 2011 Elsevier B.V. All rights reserved.
关键词[WOS]: FRESH-WATER FISH ; OXIDATIVE STRESS ; IN-SITU ; BIOCHEMICAL RESPONSES ; MICROCYSTIS BLOOMS ; OREOCHROMIS SP. ; LR ; BIOACCUMULATION ; HEPATOPANCREAS ; HEPATOTOXINS
语种: 英语
WOS记录号: WOS:000301475000016
ISSN号: 1382-6689
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/16885
Appears in Collections:淡水生态学研究中心_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China
2.Wuhan Univ Technol, Biomed Mat & Engn Ctr, Wuhan 430070, Peoples R China
3.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Peoples R China

Recommended Citation:
Qiu, Tong; Xie, Ping; Li, Li; Guo, Longgen; Zhang, Dawen; Zhou, Qiong.Nephrotoxic effects from chronic toxic cyanobacterial blooms in fishes with different trophic levels in a large Chinese lake,ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2012,33(2):252-261
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