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题名: The Cyanobacterial NAD Kinase Gene sll1415 Is Required for Photoheterotrophic Growth and Cellular Redox Homeostasis in Synechocystis sp Strain PCC 6803
作者: Gao, Hong1; Xu, Xudong1
通讯作者: Xu, XD (reprint author), Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan, Hubei, Peoples R China
刊名: JOURNAL OF BACTERIOLOGY
发表日期: 2012
DOI: 10.1128/JB.05873-11
卷: 194, 期:2, 页:218-224
收录类别: SCI
文章类型: Article
部门归属: [Gao, Hong; Xu, Xudong] Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan, Hubei, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
资助者: National Natural Science Foundation of China[30825003]; State Key Basic Research Development Program of China[2008CB418001]
类目[WOS]: Microbiology
研究领域[WOS]: Microbiology
摘要: NAD kinase (NADK), which phosphorylates NAD to NADP, is one of the key enzymes regulating the cellular NADP( H) level. In Synechocystis sp. strain PCC 6803, slr0400 and sll1415 were shown to encode NAD kinases. The NADP( H) pool in the cyanobacterium was remarkably reduced by an sll1415-null mutation but slightly reduced by an slr0400-null mutation. The reduction of the NADP( H) level in the sll1415 mutant led to a significant accumulation of glucose-6-phosphate and a loss of photoheterotrophic growth. As the primary NADK gene, sll1415 was found to inhibit the transcription of genes involved in redox homeostasis and to exert stronger effects on methyl viologen tolerance than slr0040.
英文摘要: NAD kinase (NADK), which phosphorylates NAD to NADP, is one of the key enzymes regulating the cellular NADP( H) level. In Synechocystis sp. strain PCC 6803, slr0400 and sll1415 were shown to encode NAD kinases. The NADP( H) pool in the cyanobacterium was remarkably reduced by an sll1415-null mutation but slightly reduced by an slr0400-null mutation. The reduction of the NADP( H) level in the sll1415 mutant led to a significant accumulation of glucose-6-phosphate and a loss of photoheterotrophic growth. As the primary NADK gene, sll1415 was found to inhibit the transcription of genes involved in redox homeostasis and to exert stronger effects on methyl viologen tolerance than slr0040.
关键词[WOS]: SITE-DIRECTED MUTAGENESIS ; SACCHAROMYCES-CEREVISIAE ; SP PCC-6803 ; OXIDATIVE STRESS ; COMPLEX ; BINDING ; NADP(H) ; ENZYME ; ATP
语种: 英语
WOS记录号: WOS:000298677400003
ISSN号: 0021-9193
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/16773
Appears in Collections:藻类生物学及应用研究中心_期刊论文

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作者单位: 1.Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan, Hubei, Peoples R China

Recommended Citation:
Gao, Hong; Xu, Xudong.The Cyanobacterial NAD Kinase Gene sll1415 Is Required for Photoheterotrophic Growth and Cellular Redox Homeostasis in Synechocystis sp Strain PCC 6803,JOURNAL OF BACTERIOLOGY,2012,194(2):218-224
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文件名: The Cyanobacterial NAD Kinase Gene sll1415 Is Required for Photoheterotrophic Growth and Cellular Redox Homeostasis in Synechocystis sp Strain PCC 6803.pdf
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