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In vivo studies on the immunotoxic effects of microcystins on rabbit
Yuan, Gailing1; Xie, Ping1,2; Zhang, Xuezhen1; Tang, Rong1; Gao, Yu1; Li, Dapeng1; Li, Li1; Xie, P (reprint author), Huazhong Agr Univ, Coll Fisheries, Key Lab Freshwater Biodivers Conservat & Utilizat, Minist Agr, Wuhan 430070, Peoples R China
2012-02-01
Source PublicationENVIRONMENTAL TOXICOLOGY
ISSN1520-4081
Volume27Issue:2Pages:83-89
AbstractMicrocystins (MCs) are the toxic molecules produced by common cyanobacterium in freshwater blooms. Their toxicities raise severe health issues in livestock and human beings. In current study, the immunotoxic effects of MC-LR were investigated in rabbit through evaluating the dynamics of white blood cell (WBC) numbers and cytokine production such as interleukin-3 (IL-3), IL-4, IL-6, interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha). MCs at the high dose (50 mu g MC-LReq kg-1) significantly induced increase in the WBC number but decrease in the Th1 (IFN-gamma, TNF-alpha) and Th2 (IL-3, IL-4, IL-6) production. In the low dose group(12.5 mu g MC-LReq kg-1), the number of WBC and the production of IFN-gamma, IFN-alpha, IL-4, IL-3, and IL-6 increased gradually in first 12 h, reach the peaks at 12 h, and dropped after 24 h. Significantly positive correlations were found between the cytokines production of IL-4 and IL-6, IFN-gamma and IFN-alpha, or IL-4 and IFN-gamma. In conclusion, MC-LR is able to disturb the rabbit immune system and there exists time-dose response relationship in the MC-LR-eliciting perturbation, which probably give a better insight into investigating the immunotoxicity mechanisms of MCs in vivo. (C) 2010 Wiley Periodicals, Inc. Environ Toxicol, 2012.; Microcystins (MCs) are the toxic molecules produced by common cyanobacterium in freshwater blooms. Their toxicities raise severe health issues in livestock and human beings. In current study, the immunotoxic effects of MC-LR were investigated in rabbit through evaluating the dynamics of white blood cell (WBC) numbers and cytokine production such as interleukin-3 (IL-3), IL-4, IL-6, interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha). MCs at the high dose (50 mu g MC-LReq kg-1) significantly induced increase in the WBC number but decrease in the Th1 (IFN-gamma, TNF-alpha) and Th2 (IL-3, IL-4, IL-6) production. In the low dose group(12.5 mu g MC-LReq kg-1), the number of WBC and the production of IFN-gamma, IFN-alpha, IL-4, IL-3, and IL-6 increased gradually in first 12 h, reach the peaks at 12 h, and dropped after 24 h. Significantly positive correlations were found between the cytokines production of IL-4 and IL-6, IFN-gamma and IFN-alpha, or IL-4 and IFN-gamma. In conclusion, MC-LR is able to disturb the rabbit immune system and there exists time-dose response relationship in the MC-LR-eliciting perturbation, which probably give a better insight into investigating the immunotoxicity mechanisms of MCs in vivo. (C) 2010 Wiley Periodicals, Inc. Environ Toxicol, 2012.
SubtypeArticle
KeywordMicrocystin-lr (Mc-lr) Immunotoxicity Rabbit Cytokine Wbc
Department[Yuan, Gailing; Xie, Ping; Zhang, Xuezhen; Tang, Rong; Gao, Yu; Li, Dapeng; Li, Li] Huazhong Agr Univ, Coll Fisheries, Key Lab Freshwater Biodivers Conservat & Utilizat, Minist Agr, Wuhan 430070, Peoples R China; [Xie, Ping] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China
DOI10.1002/tox.20615
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
Funding OrganizationNational Natural Science Foundation of China[30530170] ; National Natural Science Foundation of China[30530170] ; National Natural Science Foundation of China[30530170] ; National Natural Science Foundation of China[30530170]
Indexed BySCI
Language英语
WOS Research AreaEnvironmental Sciences & Ecology ; Toxicology ; Water Resources
WOS SubjectEnvironmental Sciences ; Toxicology ; Water Resources
WOS IDWOS:000299038900003
WOS KeywordCYANOBACTERIAL TOXINS ; HEPATOTOXIC MICROCYSTINS ; IMMUNE FUNCTION ; MESSENGER-RNA ; NITRIC-OXIDE ; CYTOKINES ; LR ; MACROPHAGES ; AERUGINOSA ; EXPRESSION
Funding OrganizationNational Natural Science Foundation of China[30530170] ; National Natural Science Foundation of China[30530170] ; National Natural Science Foundation of China[30530170] ; National Natural Science Foundation of China[30530170]
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Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/16719
Collection淡水生态学研究中心_期刊论文
Corresponding AuthorXie, P (reprint author), Huazhong Agr Univ, Coll Fisheries, Key Lab Freshwater Biodivers Conservat & Utilizat, Minist Agr, Wuhan 430070, Peoples R China
Affiliation1.Huazhong Agr Univ, Coll Fisheries, Key Lab Freshwater Biodivers Conservat & Utilizat, Minist Agr, Wuhan 430070, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China
Recommended Citation
GB/T 7714
Yuan, Gailing,Xie, Ping,Zhang, Xuezhen,et al. In vivo studies on the immunotoxic effects of microcystins on rabbit[J]. ENVIRONMENTAL TOXICOLOGY,2012,27(2):83-89.
APA Yuan, Gailing.,Xie, Ping.,Zhang, Xuezhen.,Tang, Rong.,Gao, Yu.,...&Xie, P .(2012).In vivo studies on the immunotoxic effects of microcystins on rabbit.ENVIRONMENTAL TOXICOLOGY,27(2),83-89.
MLA Yuan, Gailing,et al."In vivo studies on the immunotoxic effects of microcystins on rabbit".ENVIRONMENTAL TOXICOLOGY 27.2(2012):83-89.
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