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Down-regulation of heme oxygenase-1 by SVCV infection
Yuan, Junfa1; Su, Nian2; Wang, Min1; Xie, Ping2; Shi, Zhengli3; Li, Lijuan1; Li, LJ (reprint author), Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Hubei, Peoples R China
2012-02-01
Source PublicationFISH & SHELLFISH IMMUNOLOGY
ISSN1050-4648
Volume32Issue:2Pages:301-306
AbstractHeme oxygenase (HO-1) is a cytoprotective enzyme that plays a critical role in defending the body against oxidant-induced injury during inflammatory processes. In mammalian systems, viral infection or antigen expression can down-regulate the expression of HO-1. In turn, the induction of HO-1 or overexpression of HO-1 results in potent and direct antiviral activity that targets the replication of several mammalian viruses. In this study, the HO-1 gene of Cyprinus carpi was cloned, and the expression profile of HO-1 was investigated during spring viremia of carp virus (SVCV) infection. The results demonstrate that the expression of HO-1 was down-regulated during SVCV infection in the EPC cells and in common carp. These results indicated that SVCV infection could induce host oxidative stress, which may contribute to tissue injury in affect fish. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.; Heme oxygenase (HO-1) is a cytoprotective enzyme that plays a critical role in defending the body against oxidant-induced injury during inflammatory processes. In mammalian systems, viral infection or antigen expression can down-regulate the expression of HO-1. In turn, the induction of HO-1 or overexpression of HO-1 results in potent and direct antiviral activity that targets the replication of several mammalian viruses. In this study, the HO-1 gene of Cyprinus carpi was cloned, and the expression profile of HO-1 was investigated during spring viremia of carp virus (SVCV) infection. The results demonstrate that the expression of HO-1 was down-regulated during SVCV infection in the EPC cells and in common carp. These results indicated that SVCV infection could induce host oxidative stress, which may contribute to tissue injury in affect fish. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.
SubtypeArticle
KeywordSvcv Ho-1 Common Carp Heat-shock Protein 32 Oxidative Stress
Department[Yuan, Junfa; Wang, Min; Li, Lijuan] Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Hubei, Peoples R China; [Su, Nian; Xie, Ping] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan, Peoples R China; [Shi, Zhengli] Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan, Peoples R China
DOI10.1016/j.fsi.2011.11.019
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Funding OrganizationMinistry of Education of China[20100146120013]; National Natural Science Foundation of China[30700624] ; Ministry of Education of China[20100146120013]; National Natural Science Foundation of China[30700624] ; Ministry of Education of China[20100146120013]; National Natural Science Foundation of China[30700624] ; Ministry of Education of China[20100146120013]; National Natural Science Foundation of China[30700624]
Indexed BySCI
Language英语
WOS Research AreaFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS SubjectFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS IDWOS:000300751800008
WOS KeywordC VIRUS-REPLICATION ; APOPTOSIS ; STRESS ; INTERFERES ; DEFENSE ; PROTEIN ; INJURY
Funding OrganizationMinistry of Education of China[20100146120013]; National Natural Science Foundation of China[30700624] ; Ministry of Education of China[20100146120013]; National Natural Science Foundation of China[30700624] ; Ministry of Education of China[20100146120013]; National Natural Science Foundation of China[30700624] ; Ministry of Education of China[20100146120013]; National Natural Science Foundation of China[30700624]
Citation statistics
Cited Times:17[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/16707
Collection淡水生态学研究中心_期刊论文
Corresponding AuthorLi, LJ (reprint author), Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Hubei, Peoples R China
Affiliation1.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Hubei, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan, Peoples R China
3.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan, Peoples R China
Recommended Citation
GB/T 7714
Yuan, Junfa,Su, Nian,Wang, Min,et al. Down-regulation of heme oxygenase-1 by SVCV infection[J]. FISH & SHELLFISH IMMUNOLOGY,2012,32(2):301-306.
APA Yuan, Junfa.,Su, Nian.,Wang, Min.,Xie, Ping.,Shi, Zhengli.,...&Li, LJ .(2012).Down-regulation of heme oxygenase-1 by SVCV infection.FISH & SHELLFISH IMMUNOLOGY,32(2),301-306.
MLA Yuan, Junfa,et al."Down-regulation of heme oxygenase-1 by SVCV infection".FISH & SHELLFISH IMMUNOLOGY 32.2(2012):301-306.
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