IHB OpenIR  > 水生生物分子与细胞生物学研究中心  > 期刊论文
The Accuracy of Survival Time Prediction for Patients with Glioma Is Improved by Measuring Mitotic Spindle Checkpoint Gene Expression
Bie, Li; Zhao, Gang; Cheng, Pui; Rondeau, Gaelle; Porwollik, Steffen; Ju, Yan; Xia, Xiao-Qin; McClelland, Michael; Bie, L (reprint author), Jilin Univ, Clin Hosp 1, Dept Neurosurg, Changchun 130023, Peoples R China; xqxia@ihb.ac.cn; mmcclell@uci.edu
2011
Source PublicationPLOS ONE
ISSN1932-6203
Volume6Issue:10Pages:e25631
AbstractIdentification of gene expression changes that improve prediction of survival time across all glioma grades would be clinically useful. Four Affymetrix GeneChip datasets from the literature, containing data from 771 glioma samples representing all WHO grades and eight normal brain samples, were used in an ANOVA model to screen for transcript changes that correlated with grade. Observations were confirmed and extended using qPCR assays on RNA derived from 38 additional glioma samples and eight normal samples for which survival data were available. RNA levels of eight major mitotic spindle assembly checkpoint (SAC) genes (BUB1, BUB1B, BUB3, CENPE, MAD1L1, MAD2L1, CDC20, TTK) significantly correlated with glioma grade and six also significantly correlated with survival time. In particular, the level of BUB1B expression was highly correlated with survival time (p<0.0001), and significantly outperformed all other measured parameters, including two standards; WHO grade and MIB-1 (Ki-67) labeling index. Measurement of the expression levels of a small set of SAC genes may complement histological grade and other clinical parameters for predicting survival time.
KeywordCentral-nervous-system Chromosomal Instability Breast-cancer Cell-proliferation Bladder-cancer Human Astrocytomas Gastric-cancer Brain-tumors Rt-pcr Glioblastoma
Department[Bie, Li; Zhao, Gang; Ju, Yan] Jilin Univ, Clin Hosp 1, Dept Neurosurg, Changchun 130023, Peoples R China; [Bie, Li; Xia, Xiao-Qin; McClelland, Michael] Univ Calif Irvine, Dept Pathol & Lab Med, Irvine, CA USA; [Cheng, Pui; Rondeau, Gaelle; Porwollik, Steffen; Xia, Xiao-Qin; McClelland, Michael] Vaccine Res Inst San Diego, San Diego, CA USA; [Xia, Xiao-Qin] Chinese Acad Sci, Inst Hydrobiol, Wuhan, Peoples R China
Subject AreaLife Sciences & Biomedicine - Other Topics
Funding OrganizationNational Cancer Institute Early Detection Research Network[U01CA152738]; CDMRP BCRP[W81XWH-08-1-0720]; State Scholarship Fund from China[2009104187]; Jilin University ; National Cancer Institute Early Detection Research Network[U01CA152738]; CDMRP BCRP[W81XWH-08-1-0720]; State Scholarship Fund from China[2009104187]; Jilin University ; National Cancer Institute Early Detection Research Network[U01CA152738]; CDMRP BCRP[W81XWH-08-1-0720]; State Scholarship Fund from China[2009104187]; Jilin University ; National Cancer Institute Early Detection Research Network[U01CA152738]; CDMRP BCRP[W81XWH-08-1-0720]; State Scholarship Fund from China[2009104187]; Jilin University
Indexed BySCI
Language英语
WOS IDWOS:000295976000026
Funding OrganizationNational Cancer Institute Early Detection Research Network[U01CA152738]; CDMRP BCRP[W81XWH-08-1-0720]; State Scholarship Fund from China[2009104187]; Jilin University ; National Cancer Institute Early Detection Research Network[U01CA152738]; CDMRP BCRP[W81XWH-08-1-0720]; State Scholarship Fund from China[2009104187]; Jilin University ; National Cancer Institute Early Detection Research Network[U01CA152738]; CDMRP BCRP[W81XWH-08-1-0720]; State Scholarship Fund from China[2009104187]; Jilin University ; National Cancer Institute Early Detection Research Network[U01CA152738]; CDMRP BCRP[W81XWH-08-1-0720]; State Scholarship Fund from China[2009104187]; Jilin University
Citation statistics
Cited Times:42[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/16469
Collection水生生物分子与细胞生物学研究中心_期刊论文
Corresponding AuthorBie, L (reprint author), Jilin Univ, Clin Hosp 1, Dept Neurosurg, Changchun 130023, Peoples R China; xqxia@ihb.ac.cn; mmcclell@uci.edu
Recommended Citation
GB/T 7714
Bie, Li,Zhao, Gang,Cheng, Pui,et al. The Accuracy of Survival Time Prediction for Patients with Glioma Is Improved by Measuring Mitotic Spindle Checkpoint Gene Expression[J]. PLOS ONE,2011,6(10):e25631.
APA Bie, Li.,Zhao, Gang.,Cheng, Pui.,Rondeau, Gaelle.,Porwollik, Steffen.,...&mmcclell@uci.edu.(2011).The Accuracy of Survival Time Prediction for Patients with Glioma Is Improved by Measuring Mitotic Spindle Checkpoint Gene Expression.PLOS ONE,6(10),e25631.
MLA Bie, Li,et al."The Accuracy of Survival Time Prediction for Patients with Glioma Is Improved by Measuring Mitotic Spindle Checkpoint Gene Expression".PLOS ONE 6.10(2011):e25631.
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