| The Accuracy of Survival Time Prediction for Patients with Glioma Is Improved by Measuring Mitotic Spindle Checkpoint Gene Expression | |
| Bie, Li; Zhao, Gang; Cheng, Pui; Rondeau, Gaelle; Porwollik, Steffen; Ju, Yan; Xia, Xiao-Qin; McClelland, Michael; Bie, L (reprint author), Jilin Univ, Clin Hosp 1, Dept Neurosurg, Changchun 130023, Peoples R China; xqxia@ihb.ac.cn; mmcclell@uci.edu | |
| 2011 | |
| Source Publication | PLOS ONE
 |
| ISSN | 1932-6203 |
| Volume | 6Issue:10Pages:e25631 |
| Abstract | Identification of gene expression changes that improve prediction of survival time across all glioma grades would be clinically useful. Four Affymetrix GeneChip datasets from the literature, containing data from 771 glioma samples representing all WHO grades and eight normal brain samples, were used in an ANOVA model to screen for transcript changes that correlated with grade. Observations were confirmed and extended using qPCR assays on RNA derived from 38 additional glioma samples and eight normal samples for which survival data were available. RNA levels of eight major mitotic spindle assembly checkpoint (SAC) genes (BUB1, BUB1B, BUB3, CENPE, MAD1L1, MAD2L1, CDC20, TTK) significantly correlated with glioma grade and six also significantly correlated with survival time. In particular, the level of BUB1B expression was highly correlated with survival time (p<0.0001), and significantly outperformed all other measured parameters, including two standards; WHO grade and MIB-1 (Ki-67) labeling index. Measurement of the expression levels of a small set of SAC genes may complement histological grade and other clinical parameters for predicting survival time. |
| Keyword | Central-nervous-system Chromosomal Instability Breast-cancer Cell-proliferation Bladder-cancer Human Astrocytomas Gastric-cancer Brain-tumors Rt-pcr Glioblastoma |
| Department | [Bie, Li; Zhao, Gang; Ju, Yan] Jilin Univ, Clin Hosp 1, Dept Neurosurg, Changchun 130023, Peoples R China; [Bie, Li; Xia, Xiao-Qin; McClelland, Michael] Univ Calif Irvine, Dept Pathol & Lab Med, Irvine, CA USA; [Cheng, Pui; Rondeau, Gaelle; Porwollik, Steffen; Xia, Xiao-Qin; McClelland, Michael] Vaccine Res Inst San Diego, San Diego, CA USA; [Xia, Xiao-Qin] Chinese Acad Sci, Inst Hydrobiol, Wuhan, Peoples R China |
| Subject Area | Life Sciences & Biomedicine - Other Topics |
| Funding Organization | National Cancer Institute Early Detection Research Network[U01CA152738]; CDMRP BCRP[W81XWH-08-1-0720]; State Scholarship Fund from China[2009104187]; Jilin University ; National Cancer Institute Early Detection Research Network[U01CA152738]; CDMRP BCRP[W81XWH-08-1-0720]; State Scholarship Fund from China[2009104187]; Jilin University ; National Cancer Institute Early Detection Research Network[U01CA152738]; CDMRP BCRP[W81XWH-08-1-0720]; State Scholarship Fund from China[2009104187]; Jilin University ; National Cancer Institute Early Detection Research Network[U01CA152738]; CDMRP BCRP[W81XWH-08-1-0720]; State Scholarship Fund from China[2009104187]; Jilin University |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000295976000026 |
| Funding Organization | National Cancer Institute Early Detection Research Network[U01CA152738]; CDMRP BCRP[W81XWH-08-1-0720]; State Scholarship Fund from China[2009104187]; Jilin University ; National Cancer Institute Early Detection Research Network[U01CA152738]; CDMRP BCRP[W81XWH-08-1-0720]; State Scholarship Fund from China[2009104187]; Jilin University ; National Cancer Institute Early Detection Research Network[U01CA152738]; CDMRP BCRP[W81XWH-08-1-0720]; State Scholarship Fund from China[2009104187]; Jilin University ; National Cancer Institute Early Detection Research Network[U01CA152738]; CDMRP BCRP[W81XWH-08-1-0720]; State Scholarship Fund from China[2009104187]; Jilin University |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ihb.ac.cn/handle/342005/16469 |
| Collection | 水生生物分子与细胞生物学研究中心_期刊论文 |
| Corresponding Author | Bie, L (reprint author), Jilin Univ, Clin Hosp 1, Dept Neurosurg, Changchun 130023, Peoples R China; xqxia@ihb.ac.cn; mmcclell@uci.edu |
| Recommended Citation GB/T 7714 | Bie, Li,Zhao, Gang,Cheng, Pui,et al. The Accuracy of Survival Time Prediction for Patients with Glioma Is Improved by Measuring Mitotic Spindle Checkpoint Gene Expression[J]. PLOS ONE,2011,6(10):e25631. |
| APA | Bie, Li.,Zhao, Gang.,Cheng, Pui.,Rondeau, Gaelle.,Porwollik, Steffen.,...&mmcclell@uci.edu.(2011).The Accuracy of Survival Time Prediction for Patients with Glioma Is Improved by Measuring Mitotic Spindle Checkpoint Gene Expression.PLOS ONE,6(10),e25631. |
| MLA | Bie, Li,et al."The Accuracy of Survival Time Prediction for Patients with Glioma Is Improved by Measuring Mitotic Spindle Checkpoint Gene Expression".PLOS ONE 6.10(2011):e25631. |
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