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学科主题: Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
题名: Comparisons of IL-8, ROS and p53 responses in human lung epithelial cells exposed to two extracts of PM2.5 collected from an e-waste recycling area, China
作者: Yang, Fangxing ; Jin, Shiwei ; Xu, Ying ; Lu, Yuanan
通讯作者: Yang, FX (reprint author), Zhejiang Univ, Coll Environm & Resource Sci, Hangzhou 310003, Zhejiang, Peoples R China ; fxyang@ihb.ac.cn ; ylu@hawaii.edu
关键词: IL-8 ; ROS ; p53 ; PM2.5 ; A549 cells ; e-waste
刊名: ENVIRONMENTAL RESEARCH LETTERS
发表日期: 2011
卷: 6, 期:2, 页:24013
收录类别: SCI
部门归属: [Yang, Fangxing] Zhejiang Univ, Coll Environm & Resource Sci, Hangzhou 310003, Zhejiang, Peoples R China; [Yang, Fangxing; Xu, Ying; Lu, Yuanan] Chinese Acad Sci, Inst Hydrobiol, Wuhan, Peoples R China; [Jin, Shiwei] Wuhan Inst Technol, Key Lab Green Chem Proc, Minist Educ, Wuhan, Peoples R China; [Lu, Yuanan] Univ Hawaii, John A Burns Sch Med, Dept Publ Hlth Sci, Honolulu, HI 96822 USA
资助者: National Natural Science Foundation of China; 863 Research Project[20890113, 2009AA06Z407, 20607030]; Wildlife Trust International; University of Hawaii National Science Foundation[0549514]
摘要: To identify the different effects of organic-soluble and water-soluble pollutants adsorbed on PM2.5 (PM: particulate matter) released from e-waste (electrical/electronic waste) on inflammatory response, oxidative stress and DNA damage, interleukin-8 (IL-8), reactive oxygen species (ROS) and p53 protein levels were determined and compared in human lung epithelial A549 cells exposed to extracts of PM2.5 collected from two sampling sites in an e-waste recycling area in China. It is found that both extracts induced increases of IL-8 release, ROS production and p53 protein expression. The differences between the organic-soluble and water-soluble extracts were determined as of significance for ROS production (p < 0.05) and p53 protein expression (p < 0.01). The ROS production and p53 protein expression induced by the organic-soluble extracts were found to be greater than those induced by the water-soluble extracts, for both sampling sites. The results indicated that PM2.5 collected from the e-waste recycling areas could lead to inflammatory response, oxidative stress and DNA damage, and the organic-soluble extracts had higher potential to induce such adverse effects on human health.
语种: 英语
WOS记录号: WOS:000295326800013
ISSN号: 1748-9326
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/16459
Appears in Collections:水环境工程研究中心_期刊论文

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Yang, Fangxing; Jin, Shiwei; Xu, Ying; Lu, Yuanan.Comparisons of IL-8, ROS and p53 responses in human lung epithelial cells exposed to two extracts of PM2.5 collected from an e-waste recycling area, China,ENVIRONMENTAL RESEARCH LETTERS,2011,6(2):24013
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