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Comparisons of IL-8, ROS and p53 responses in human lung epithelial cells exposed to two extracts of PM2.5 collected from an e-waste recycling area, China
Yang, Fangxing; Jin, Shiwei; Xu, Ying; Lu, Yuanan; Yang, FX (reprint author), Zhejiang Univ, Coll Environm & Resource Sci, Hangzhou 310003, Zhejiang, Peoples R China; fxyang@ihb.ac.cn; ylu@hawaii.edu
2011
Source PublicationENVIRONMENTAL RESEARCH LETTERS
ISSN1748-9326
Volume6Issue:2Pages:24013
AbstractTo identify the different effects of organic-soluble and water-soluble pollutants adsorbed on PM2.5 (PM: particulate matter) released from e-waste (electrical/electronic waste) on inflammatory response, oxidative stress and DNA damage, interleukin-8 (IL-8), reactive oxygen species (ROS) and p53 protein levels were determined and compared in human lung epithelial A549 cells exposed to extracts of PM2.5 collected from two sampling sites in an e-waste recycling area in China. It is found that both extracts induced increases of IL-8 release, ROS production and p53 protein expression. The differences between the organic-soluble and water-soluble extracts were determined as of significance for ROS production (p < 0.05) and p53 protein expression (p < 0.01). The ROS production and p53 protein expression induced by the organic-soluble extracts were found to be greater than those induced by the water-soluble extracts, for both sampling sites. The results indicated that PM2.5 collected from the e-waste recycling areas could lead to inflammatory response, oxidative stress and DNA damage, and the organic-soluble extracts had higher potential to induce such adverse effects on human health.
KeywordIl-8 Ros P53 Pm2.5 A549 Cells E-waste
Department[Yang, Fangxing] Zhejiang Univ, Coll Environm & Resource Sci, Hangzhou 310003, Zhejiang, Peoples R China; [Yang, Fangxing; Xu, Ying; Lu, Yuanan] Chinese Acad Sci, Inst Hydrobiol, Wuhan, Peoples R China; [Jin, Shiwei] Wuhan Inst Technol, Key Lab Green Chem Proc, Minist Educ, Wuhan, Peoples R China; [Lu, Yuanan] Univ Hawaii, John A Burns Sch Med, Dept Publ Hlth Sci, Honolulu, HI 96822 USA
Subject AreaEnvironmental Sciences & Ecology ; Meteorology & Atmospheric Sciences
Funding OrganizationNational Natural Science Foundation of China; 863 Research Project[20890113, 2009AA06Z407, 20607030]; Wildlife Trust International; University of Hawaii National Science Foundation[0549514] ; National Natural Science Foundation of China; 863 Research Project[20890113, 2009AA06Z407, 20607030]; Wildlife Trust International; University of Hawaii National Science Foundation[0549514] ; National Natural Science Foundation of China; 863 Research Project[20890113, 2009AA06Z407, 20607030]; Wildlife Trust International; University of Hawaii National Science Foundation[0549514] ; National Natural Science Foundation of China; 863 Research Project[20890113, 2009AA06Z407, 20607030]; Wildlife Trust International; University of Hawaii National Science Foundation[0549514]
Indexed BySCI
Language英语
WOS IDWOS:000295326800013
Funding OrganizationNational Natural Science Foundation of China; 863 Research Project[20890113, 2009AA06Z407, 20607030]; Wildlife Trust International; University of Hawaii National Science Foundation[0549514] ; National Natural Science Foundation of China; 863 Research Project[20890113, 2009AA06Z407, 20607030]; Wildlife Trust International; University of Hawaii National Science Foundation[0549514] ; National Natural Science Foundation of China; 863 Research Project[20890113, 2009AA06Z407, 20607030]; Wildlife Trust International; University of Hawaii National Science Foundation[0549514] ; National Natural Science Foundation of China; 863 Research Project[20890113, 2009AA06Z407, 20607030]; Wildlife Trust International; University of Hawaii National Science Foundation[0549514]
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/16459
Collection水环境工程研究中心_期刊论文
Corresponding AuthorYang, FX (reprint author), Zhejiang Univ, Coll Environm & Resource Sci, Hangzhou 310003, Zhejiang, Peoples R China; fxyang@ihb.ac.cn; ylu@hawaii.edu
Recommended Citation
GB/T 7714
Yang, Fangxing,Jin, Shiwei,Xu, Ying,et al. Comparisons of IL-8, ROS and p53 responses in human lung epithelial cells exposed to two extracts of PM2.5 collected from an e-waste recycling area, China[J]. ENVIRONMENTAL RESEARCH LETTERS,2011,6(2):24013.
APA Yang, Fangxing.,Jin, Shiwei.,Xu, Ying.,Lu, Yuanan.,Yang, FX .,...&ylu@hawaii.edu.(2011).Comparisons of IL-8, ROS and p53 responses in human lung epithelial cells exposed to two extracts of PM2.5 collected from an e-waste recycling area, China.ENVIRONMENTAL RESEARCH LETTERS,6(2),24013.
MLA Yang, Fangxing,et al."Comparisons of IL-8, ROS and p53 responses in human lung epithelial cells exposed to two extracts of PM2.5 collected from an e-waste recycling area, China".ENVIRONMENTAL RESEARCH LETTERS 6.2(2011):24013.
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