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学科主题: Immunology
题名: Acquisition of Humoral Transplantation Tolerance upon De Novo Emergence of B Lymphocytes
作者: Parsons, Ronald F. ; Vivek, Kumar ; Rostami, Susan Y. ; Zekavat, Ghazal ; Ziaie, Seyed M. ; Luo, Yanping ; Koeberlein, Brigitte ; Redfield, Robert R. ; Cancro, Michael P. ; Naji, Ali ; Noorchashm, Hooman
通讯作者: Noorchashm, H (reprint author), Univ Penn, Sch Med, Harrison Dept Surg Res, 329 Stemmler Hall, Philadelphia, PA 19104 USA ; hooman.noorchashm@uphs.upenn.edu
关键词: DONOR-SPECIFIC TRANSFUSIONS ; HEAT-STABLE ANTIGEN(HI) ; MAINTENANCE IMMUNOSUPPRESSION ; ALLOGRAFT RECIPIENTS ; PERIPHERAL DELETION ; CHRONIC REJECTION ; CELL MATURATION ; MIXED CHIMERISM ; CLONAL DELETION ; T-CELL
刊名: JOURNAL OF IMMUNOLOGY
发表日期: 2011
卷: 186, 期:1, 页:614-620
收录类别: SCI
部门归属: [Parsons, Ronald F.; Vivek, Kumar; Rostami, Susan Y.; Zekavat, Ghazal; Ziaie, Seyed M.; Luo, Yanping; Koeberlein, Brigitte; Redfield, Robert R.; Naji, Ali; Noorchashm, Hooman] Univ Penn, Sch Med, Harrison Dept Surg Res, Philadelphia, PA 19104 USA; [Cancro, Michael P.] Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA; [Luo, Yanping] Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan, Peoples R China
资助者: National Institutes of Health[KO8-DK064603, RO3-DK080286, T32DK007314-29]; Juvenile Diabetes Research Foundation[4-2008-351]
摘要: A major obstacle to transplantation tolerance is humoral immunity. In this paper, we demonstrate that the intrinsic developmental propensity of the B lymphocyte compartment for acquisition of self-tolerance can be harnessed to induce humoral unresponsiveness to transplanted alloantigens. In the current study, when transitional B cells developed in the presence of donor lymphoid cells, the mature B lymphocyte compartment failed to mount a donor-specific alloantibody response to an organ transplant-despite unrestrained acute T cell-mediated allograft rejection. Specifically, we generated an experimental system wherein a B6 strain B cell compartment developed de novo in the presence of F1 (B6xBALB/c) lymphoid cells and in a T cell-deficient setting. Following establishment of a steady-state B cell compartment, these B6 mice were transplanted with heterotopic cardiac allografts from allogeneic BALB/c donors. The mice were then inoculated with purified syngeneic B6 T cells. As expected, all cardiac allografts were acutely rejected. However, the B lymphocyte compartment of these mice was completely inert in its capacity to form a BALB/c-specific alloantibody response. Using an alloantigen-specific Ig transgenic system, we demonstrated that this profound degree of humoral tolerance was caused by clonal deletion of alloreactive specificities from the primary B cell repertoire. Thus, de novo B cell compartment development at the time of transplantation is of critical importance in recipient repertoire "remodeling" to a humoral tolerant state. The Journal of Immunology, 2011, 186: 614-620.
语种: 英语
WOS记录号: WOS:000285688700069
ISSN号: 0022-1767
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/16443
Appears in Collections:鱼类生物学及渔业生物技术研究中心_期刊论文

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Parsons, Ronald F.; Vivek, Kumar; Rostami, Susan Y.; Zekavat, Ghazal; Ziaie, Seyed M.; Luo, Yanping; Koeberlein, Brigitte; Redfield, Robert R.; Cancro, Michael P.; Naji, Ali; Noorchashm, Hooman.Acquisition of Humoral Transplantation Tolerance upon De Novo Emergence of B Lymphocytes,JOURNAL OF IMMUNOLOGY,2011,186(1):614-620
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