IHB OpenIR  > 鱼类生物学及渔业生物技术研究中心  > 期刊论文
Acquisition of Humoral Transplantation Tolerance upon De Novo Emergence of B Lymphocytes
Parsons, Ronald F.; Vivek, Kumar; Rostami, Susan Y.; Zekavat, Ghazal; Ziaie, Seyed M.; Luo, Yanping; Koeberlein, Brigitte; Redfield, Robert R.; Cancro, Michael P.; Naji, Ali; Noorchashm, Hooman; Noorchashm, H (reprint author), Univ Penn, Sch Med, Harrison Dept Surg Res, 329 Stemmler Hall, Philadelphia, PA 19104 USA; hooman.noorchashm@uphs.upenn.edu
2011
Source PublicationJOURNAL OF IMMUNOLOGY
ISSN0022-1767
Volume186Issue:1Pages:614-620
AbstractA major obstacle to transplantation tolerance is humoral immunity. In this paper, we demonstrate that the intrinsic developmental propensity of the B lymphocyte compartment for acquisition of self-tolerance can be harnessed to induce humoral unresponsiveness to transplanted alloantigens. In the current study, when transitional B cells developed in the presence of donor lymphoid cells, the mature B lymphocyte compartment failed to mount a donor-specific alloantibody response to an organ transplant-despite unrestrained acute T cell-mediated allograft rejection. Specifically, we generated an experimental system wherein a B6 strain B cell compartment developed de novo in the presence of F1 (B6xBALB/c) lymphoid cells and in a T cell-deficient setting. Following establishment of a steady-state B cell compartment, these B6 mice were transplanted with heterotopic cardiac allografts from allogeneic BALB/c donors. The mice were then inoculated with purified syngeneic B6 T cells. As expected, all cardiac allografts were acutely rejected. However, the B lymphocyte compartment of these mice was completely inert in its capacity to form a BALB/c-specific alloantibody response. Using an alloantigen-specific Ig transgenic system, we demonstrated that this profound degree of humoral tolerance was caused by clonal deletion of alloreactive specificities from the primary B cell repertoire. Thus, de novo B cell compartment development at the time of transplantation is of critical importance in recipient repertoire "remodeling" to a humoral tolerant state. The Journal of Immunology, 2011, 186: 614-620.
KeywordDonor-specific Transfusions Heat-stable Antigen(Hi) Maintenance Immunosuppression Allograft Recipients Peripheral Deletion Chronic Rejection Cell Maturation Mixed Chimerism Clonal Deletion T-cell
Department[Parsons, Ronald F.; Vivek, Kumar; Rostami, Susan Y.; Zekavat, Ghazal; Ziaie, Seyed M.; Luo, Yanping; Koeberlein, Brigitte; Redfield, Robert R.; Naji, Ali; Noorchashm, Hooman] Univ Penn, Sch Med, Harrison Dept Surg Res, Philadelphia, PA 19104 USA; [Cancro, Michael P.] Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA; [Luo, Yanping] Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan, Peoples R China
Subject AreaImmunology
Funding OrganizationNational Institutes of Health[KO8-DK064603, RO3-DK080286, T32DK007314-29]; Juvenile Diabetes Research Foundation[4-2008-351] ; National Institutes of Health[KO8-DK064603, RO3-DK080286, T32DK007314-29]; Juvenile Diabetes Research Foundation[4-2008-351] ; National Institutes of Health[KO8-DK064603, RO3-DK080286, T32DK007314-29]; Juvenile Diabetes Research Foundation[4-2008-351] ; National Institutes of Health[KO8-DK064603, RO3-DK080286, T32DK007314-29]; Juvenile Diabetes Research Foundation[4-2008-351]
Indexed BySCI
Language英语
WOS IDWOS:000285688700069
Funding OrganizationNational Institutes of Health[KO8-DK064603, RO3-DK080286, T32DK007314-29]; Juvenile Diabetes Research Foundation[4-2008-351] ; National Institutes of Health[KO8-DK064603, RO3-DK080286, T32DK007314-29]; Juvenile Diabetes Research Foundation[4-2008-351] ; National Institutes of Health[KO8-DK064603, RO3-DK080286, T32DK007314-29]; Juvenile Diabetes Research Foundation[4-2008-351] ; National Institutes of Health[KO8-DK064603, RO3-DK080286, T32DK007314-29]; Juvenile Diabetes Research Foundation[4-2008-351]
Citation statistics
Cited Times:24[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/16443
Collection鱼类生物学及渔业生物技术研究中心_期刊论文
Corresponding AuthorNoorchashm, H (reprint author), Univ Penn, Sch Med, Harrison Dept Surg Res, 329 Stemmler Hall, Philadelphia, PA 19104 USA; hooman.noorchashm@uphs.upenn.edu
Recommended Citation
GB/T 7714
Parsons, Ronald F.,Vivek, Kumar,Rostami, Susan Y.,et al. Acquisition of Humoral Transplantation Tolerance upon De Novo Emergence of B Lymphocytes[J]. JOURNAL OF IMMUNOLOGY,2011,186(1):614-620.
APA Parsons, Ronald F..,Vivek, Kumar.,Rostami, Susan Y..,Zekavat, Ghazal.,Ziaie, Seyed M..,...&hooman.noorchashm@uphs.upenn.edu.(2011).Acquisition of Humoral Transplantation Tolerance upon De Novo Emergence of B Lymphocytes.JOURNAL OF IMMUNOLOGY,186(1),614-620.
MLA Parsons, Ronald F.,et al."Acquisition of Humoral Transplantation Tolerance upon De Novo Emergence of B Lymphocytes".JOURNAL OF IMMUNOLOGY 186.1(2011):614-620.
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