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学科主题: Life Sciences & Biomedicine - Other Topics
题名: Analysis of MicroRNA Expression in Embryonic Developmental Toxicity Induced by MC-RR
作者: Zhao, Yanyan ; Xiong, Qian ; Xie, Ping
通讯作者: Zhao, YY (reprint author), Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosys, Wuhan, Peoples R China ; xieping@ihb.ac.cn
关键词: CYPRINUS-CARPIO L. ; MICROCYSTIN-LR ; GENE-EXPRESSION ; ZEBRAFISH DEVELOPMENT ; NEGATIVE REGULATOR ; RNA-INTERFERENCE ; DANIO-RERIO ; CYANOBACTERIA ; DICER ; EXTRACT
刊名: PLOS ONE
发表日期: 2011
卷: 6, 期:7, 页:e22676
收录类别: SCI
部门归属: [Zhao, Yanyan; Xiong, Qian; Xie, Ping] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosys, Wuhan, Peoples R China; [Zhao, Yanyan; Xiong, Qian] Chinese Acad Sci, Grad Sch, Wuhan, Peoples R China
资助者: National Basic Research Program of China (973 Program)[2008CB418101]; National Natural Science Foundation of China[31070457]
摘要: As cynobacterial blooms frequently occur in fresh waters throughout the world, microcystins (MCs) have caused serious damage to both wildlife and human health. MCs are known to have developmental toxicity, however, the possible molecular mechanism is largely unknown. This is the first toxicological study to integrate post-transcriptomic, proteomic and bioinformatics analysis to explore molecular mechanisms for developmental toxicity of MCs in zebrafish. After being microinjected directly into embryos, MC-RR dose-dependently decreased survival rates and increased malformation rates of embryos, causing various embryo abnormalities including loss of vascular integrity and hemorrhage. Expressions of 31 microRNAs (miRNAs) and 78 proteins were significantly affected at 72 hours post-fertilisation (hpf). Expressions of miR-430 and miR-125 families were also significantly changed. The altered expressions of miR-31 and miR-126 were likely responsible for the loss of vascular integrity. MC-RR significantly reduced the expressions of a number of proteins involved in energy metabolism, cell division, protein synthesis, cytoskeleton maintenance, response to stress and DNA replication. Bioinformatics analysis shows that several aberrantly expressed miRNAs and proteins (involved in various molecular pathways) were predicted to be potential MC-responsive miRNA-target pairs, and that their aberrant expressions should be the possible molecular mechanisms for the various developmental defects caused by MC-RR.
语种: 英语
WOS记录号: WOS:000293286500017
ISSN号: 1932-6203
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/16431
Appears in Collections:淡水生态学研究中心_期刊论文

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Zhao, Yanyan; Xiong, Qian; Xie, Ping.Analysis of MicroRNA Expression in Embryonic Developmental Toxicity Induced by MC-RR,PLOS ONE,2011,6(7):e22676
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