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学科主题: Life Sciences & Biomedicine - Other Topics
题名: Evolutionary Patterns of RNA-Based Duplication in Non-Mammalian Chordates
作者: Chen, Ming ; Zou, Ming ; Fu, Beide ; Li, Xin ; Vibranovski, Maria D. ; Gan, Xiaoni ; Wang, Dengqiang ; Wang, Wen ; Long, Manyuan ; He, Shunping
通讯作者: Chen, M (reprint author), Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan, Peoples R China ; mlong@uchicago.edu ; clad@ihb.ac.cn
关键词: NON-LTR RETROTRANSPOSONS ; HUMAN GENOME ; PROCESSED PSEUDOGENES ; SEX-CHROMOSOMES ; GENE ; DROSOPHILA ; DNA ; REVEALS ; FISH ; RETROGENES
刊名: PLOS ONE
发表日期: 2011
卷: 6, 期:7, 页:e21466
收录类别: SCI
部门归属: [Chen, Ming; Zou, Ming; Fu, Beide; Gan, Xiaoni; Wang, Dengqiang; He, Shunping] Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan, Peoples R China; [Li, Xin; Wang, Wen] Chinese Acad Sci, Kunming Inst Zool, Kunming, Yunnan Province, Peoples R China; [Vibranovski, Maria D.; Long, Manyuan] Univ Chicago, Dept Ecol & Evolut, Chicago, IL 60637 USA; [Chen, Ming; Zou, Ming; Fu, Beide; Gan, Xiaoni; Wang, Dengqiang] Chinese Acad Sci, Grad Univ, Beijing, Peoples R China; [Wang, Dengqiang] Chinese Acad Fisheries Sci, Yangtze River Fisheries Res Inst, Wuhan, Peoples R China
资助者: National Natural Science Foundation of China[2007CB411601]
摘要: The role of RNA-based duplication, or retroposition, in the evolution of new gene functions in mammals, plants, and Drosophila has been widely reported. However, little is known about RNA-based duplication in non-mammalian chordates. In this study, we screened ten non-mammalian chordate genomes for retrocopies and investigated their evolutionary patterns. We identified numerous retrocopies in these species. Examination of the age distribution of these retrocopies revealed no burst of young retrocopies in ancient chordate species. Upon comparing these non-mammalian chordate species to the mammalian species, we observed that a larger fraction of the non-mammalian retrocopies was under strong evolutionary constraints than mammalian retrocopies are, as evidenced by signals of purifying selection and expression profiles. For the Western clawed frog, Medaka, and Sea squirt, many retrogenes have evolved gonad and brain expression patterns, similar to what was observed in human. Testing of retrogene movement in the Medaka genome, where the nascent sex chrosomes have been well assembled, did not reveal any significant gene movement. Taken together, our analyses demonstrate that RNA-based duplication generates many functional genes and can make a significant contribution to the evolution of non-mammalian genomes.
语种: 英语
WOS记录号: WOS:000292680900006
ISSN号: 1932-6203
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/16399
Appears in Collections:水生生物多样性与资源保护研究中心_期刊论文

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Recommended Citation:
Chen, Ming; Zou, Ming; Fu, Beide; Li, Xin; Vibranovski, Maria D.; Gan, Xiaoni; Wang, Dengqiang; Wang, Wen; Long, Manyuan; He, Shunping.Evolutionary Patterns of RNA-Based Duplication in Non-Mammalian Chordates,PLOS ONE,2011,6(7):e21466
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